Role of gut microbes in acute lung injury/acute respiratory distress syndrome
Acute lung injury (ALI) is an acute, diffuse inflammatory lung condition triggered by factors of severe infections, trauma, shock, burns, ischemia-reperfusion, and mechanical ventilation. It is primarily characterized by refractory hypoxemia and respiratory distress. The more severe form, acute resp...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2024.2440125 |
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| author | Zixuan Ren Zhihuan Zheng Xiujing Feng |
| author_facet | Zixuan Ren Zhihuan Zheng Xiujing Feng |
| author_sort | Zixuan Ren |
| collection | DOAJ |
| description | Acute lung injury (ALI) is an acute, diffuse inflammatory lung condition triggered by factors of severe infections, trauma, shock, burns, ischemia-reperfusion, and mechanical ventilation. It is primarily characterized by refractory hypoxemia and respiratory distress. The more severe form, acute respiratory distress syndrome (ARDS), can progress to multi-organ failure and has a high mortality rate. Despite extensive research, the exact pathogenesis of ALI and ARDS remains complex and not fully understood. Recent advancements in studying the gut microecology of patients have revealed the critical role that gut microbes play in ALI/ARDS onset and progression. While the exact mechanisms are still under investigation, evidence increasingly points to the influence of gut microbes and their metabolites on ALI/ARDS. This review aims to summarize the role of gut microbes and their metabolites in ALI/ARDS caused by various triggers. Moreover, it explores potential mechanisms and discusses how gut microbe-targeting interventions might offer new clinical strategies for the treatment of ALI/ARDS. |
| format | Article |
| id | doaj-art-5990f556acdb4d5f88c2f38b9f8e4c3d |
| institution | Kabale University |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-5990f556acdb4d5f88c2f38b9f8e4c3d2024-12-11T05:06:22ZengTaylor & Francis GroupGut Microbes1949-09761949-09842024-12-0116110.1080/19490976.2024.2440125Role of gut microbes in acute lung injury/acute respiratory distress syndromeZixuan Ren0Zhihuan Zheng1Xiujing Feng2Shandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaShandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaShandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaAcute lung injury (ALI) is an acute, diffuse inflammatory lung condition triggered by factors of severe infections, trauma, shock, burns, ischemia-reperfusion, and mechanical ventilation. It is primarily characterized by refractory hypoxemia and respiratory distress. The more severe form, acute respiratory distress syndrome (ARDS), can progress to multi-organ failure and has a high mortality rate. Despite extensive research, the exact pathogenesis of ALI and ARDS remains complex and not fully understood. Recent advancements in studying the gut microecology of patients have revealed the critical role that gut microbes play in ALI/ARDS onset and progression. While the exact mechanisms are still under investigation, evidence increasingly points to the influence of gut microbes and their metabolites on ALI/ARDS. This review aims to summarize the role of gut microbes and their metabolites in ALI/ARDS caused by various triggers. Moreover, it explores potential mechanisms and discusses how gut microbe-targeting interventions might offer new clinical strategies for the treatment of ALI/ARDS.https://www.tandfonline.com/doi/10.1080/19490976.2024.2440125Gut microbeacute lung injuryacute respiratory distress syndromegut–lung axis |
| spellingShingle | Zixuan Ren Zhihuan Zheng Xiujing Feng Role of gut microbes in acute lung injury/acute respiratory distress syndrome Gut Microbes Gut microbe acute lung injury acute respiratory distress syndrome gut–lung axis |
| title | Role of gut microbes in acute lung injury/acute respiratory distress syndrome |
| title_full | Role of gut microbes in acute lung injury/acute respiratory distress syndrome |
| title_fullStr | Role of gut microbes in acute lung injury/acute respiratory distress syndrome |
| title_full_unstemmed | Role of gut microbes in acute lung injury/acute respiratory distress syndrome |
| title_short | Role of gut microbes in acute lung injury/acute respiratory distress syndrome |
| title_sort | role of gut microbes in acute lung injury acute respiratory distress syndrome |
| topic | Gut microbe acute lung injury acute respiratory distress syndrome gut–lung axis |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2024.2440125 |
| work_keys_str_mv | AT zixuanren roleofgutmicrobesinacutelunginjuryacuterespiratorydistresssyndrome AT zhihuanzheng roleofgutmicrobesinacutelunginjuryacuterespiratorydistresssyndrome AT xiujingfeng roleofgutmicrobesinacutelunginjuryacuterespiratorydistresssyndrome |