Association of FAS and FAS Ligand Genes Polymorphism and Risk of Systemic Lupus Erythematosus
FAS/FASL pathway plays a critical role in maintaining peripheral immune tolerance; therefore, the apoptosis genes, Fas and Fas ligand (FasL), could be suitable candidate genes in human SLE susceptibility. Materials and Methods. In this case-control study, 106 SLE patients and 149 sex, age, and ethni...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/176741 |
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| author | Bita Moudi Saeedeh Salimi Farzaneh Farajian Mashhadi Mahnaz Sandoughi Zahra Zakeri |
| author_facet | Bita Moudi Saeedeh Salimi Farzaneh Farajian Mashhadi Mahnaz Sandoughi Zahra Zakeri |
| author_sort | Bita Moudi |
| collection | DOAJ |
| description | FAS/FASL pathway plays a critical role in maintaining peripheral immune tolerance; therefore, the apoptosis genes, Fas and Fas ligand (FasL), could be suitable candidate genes in human SLE susceptibility. Materials and Methods. In this case-control study, 106 SLE patients and 149 sex, age, and ethnicity matched healthy controls were genotyped for the Fas A-670G and FasLC-844T polymorphisms by polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP). Results. The frequency of -670AA genotype was significantly higher in SLE patients than control group and the risk of SLE was 2.1-fold greater in subjects with AA genotype (P=0.03). The frequency of -670A allele was significantly higher in SLE patients than in controls too (58% versus 49%, P=0.03). The -844CC genotype frequency was significantly higher in SLE patients than in healthy controls and the risk of SLE was 2.8-fold greater in these subjects (P=0.01). The C allele frequency was significantly higher in patients than in controls (69% versus 49%, P=0.001). Increased SLE risk was observed in individuals with combined effect of Fas-670AA and FasL-844CC genotypes (P=0.001). Conclusion. Fas-670AA and FasL-844CC genotypes were associated with SLE risk, and combined effect of -670AA and -844CC genotypes might increase SLE susceptibility. |
| format | Article |
| id | doaj-art-598d87b7727446e187472b26ac22127c |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-598d87b7727446e187472b26ac22127c2025-02-03T01:31:30ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/176741176741Association of FAS and FAS Ligand Genes Polymorphism and Risk of Systemic Lupus ErythematosusBita Moudi0Saeedeh Salimi1Farzaneh Farajian Mashhadi2Mahnaz Sandoughi3Zahra Zakeri4Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, IranCellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, IranCellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, IranDepartment of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, IranDepartment of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, IranFAS/FASL pathway plays a critical role in maintaining peripheral immune tolerance; therefore, the apoptosis genes, Fas and Fas ligand (FasL), could be suitable candidate genes in human SLE susceptibility. Materials and Methods. In this case-control study, 106 SLE patients and 149 sex, age, and ethnicity matched healthy controls were genotyped for the Fas A-670G and FasLC-844T polymorphisms by polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP). Results. The frequency of -670AA genotype was significantly higher in SLE patients than control group and the risk of SLE was 2.1-fold greater in subjects with AA genotype (P=0.03). The frequency of -670A allele was significantly higher in SLE patients than in controls too (58% versus 49%, P=0.03). The -844CC genotype frequency was significantly higher in SLE patients than in healthy controls and the risk of SLE was 2.8-fold greater in these subjects (P=0.01). The C allele frequency was significantly higher in patients than in controls (69% versus 49%, P=0.001). Increased SLE risk was observed in individuals with combined effect of Fas-670AA and FasL-844CC genotypes (P=0.001). Conclusion. Fas-670AA and FasL-844CC genotypes were associated with SLE risk, and combined effect of -670AA and -844CC genotypes might increase SLE susceptibility.http://dx.doi.org/10.1155/2013/176741 |
| spellingShingle | Bita Moudi Saeedeh Salimi Farzaneh Farajian Mashhadi Mahnaz Sandoughi Zahra Zakeri Association of FAS and FAS Ligand Genes Polymorphism and Risk of Systemic Lupus Erythematosus The Scientific World Journal |
| title | Association of FAS and FAS Ligand Genes Polymorphism and Risk of Systemic Lupus Erythematosus |
| title_full | Association of FAS and FAS Ligand Genes Polymorphism and Risk of Systemic Lupus Erythematosus |
| title_fullStr | Association of FAS and FAS Ligand Genes Polymorphism and Risk of Systemic Lupus Erythematosus |
| title_full_unstemmed | Association of FAS and FAS Ligand Genes Polymorphism and Risk of Systemic Lupus Erythematosus |
| title_short | Association of FAS and FAS Ligand Genes Polymorphism and Risk of Systemic Lupus Erythematosus |
| title_sort | association of fas and fas ligand genes polymorphism and risk of systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2013/176741 |
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