Study of the pharmacokinetics of antituberculosis drug Biomairin
Resume. The results of a studying the pharmacokinetics of the anti-tuberculosis drug Biomayrin in experimental animals (rats) after oral administration were presented. A comparative analysis of the pharmacokinetic parameters of Biomayrin with a comparing drug (a mixture of rifampicin, ethambutol and...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2018-11-01
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| Series: | Фармакокинетика и Фармакодинамика |
| Subjects: | |
| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/76 |
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| _version_ | 1849693886578950144 |
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| author | Sh. A. Shomurotov E. M. Sultanova M. K. Salakhutdinova U. J. Ishimov J. F. Ziyavitdinov O. N. Veshkurova A. S. Turaev |
| author_facet | Sh. A. Shomurotov E. M. Sultanova M. K. Salakhutdinova U. J. Ishimov J. F. Ziyavitdinov O. N. Veshkurova A. S. Turaev |
| author_sort | Sh. A. Shomurotov |
| collection | DOAJ |
| description | Resume. The results of a studying the pharmacokinetics of the anti-tuberculosis drug Biomayrin in experimental animals (rats) after oral administration were presented. A comparative analysis of the pharmacokinetic parameters of Biomayrin with a comparing drug (a mixture of rifampicin, ethambutol and isoniazid) showed that the bioavailability of isoniazid increased four times as a part of Biomayrin, the ethambutol and rifampicin three times compared to the comparing drug, thereby showing a prolonged effect. It should also be noted that the introduction of isoniazid into the polysaccharide matrix retards its metabolism to the therapeutically inactive acetylisoniazid. |
| format | Article |
| id | doaj-art-59870ee9723f47ef9bfb7492f5e1bddf |
| institution | DOAJ |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2018-11-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-59870ee9723f47ef9bfb7492f5e1bddf2025-08-20T03:20:16ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302018-11-0104505510.24411/2587-7836-2018-1003075Study of the pharmacokinetics of antituberculosis drug BiomairinSh. A. Shomurotov0E. M. Sultanova1M. K. Salakhutdinova2U. J. Ishimov3J. F. Ziyavitdinov4O. N. Veshkurova5A. S. Turaev6Institute of Bioorganic Chemistry, Academy of Sciences of UzbekistanInstitute of Bioorganic Chemistry, Academy of Sciences of UzbekistanInstitute of Bioorganic Chemistry, Academy of Sciences of UzbekistanInstitute of Bioorganic Chemistry, Academy of Sciences of UzbekistanInstitute of Bioorganic Chemistry, Academy of Sciences of UzbekistanInstitute of Bioorganic Chemistry, Academy of Sciences of UzbekistanInstitute of Bioorganic Chemistry, Academy of Sciences of UzbekistanResume. The results of a studying the pharmacokinetics of the anti-tuberculosis drug Biomayrin in experimental animals (rats) after oral administration were presented. A comparative analysis of the pharmacokinetic parameters of Biomayrin with a comparing drug (a mixture of rifampicin, ethambutol and isoniazid) showed that the bioavailability of isoniazid increased four times as a part of Biomayrin, the ethambutol and rifampicin three times compared to the comparing drug, thereby showing a prolonged effect. It should also be noted that the introduction of isoniazid into the polysaccharide matrix retards its metabolism to the therapeutically inactive acetylisoniazid.https://www.pharmacokinetica.ru/jour/article/view/76биомайринизониазидэтамбутолрифампицинацетилизониазидbiomayrinisoniazidethambutolrifampicinacetylisoniazid |
| spellingShingle | Sh. A. Shomurotov E. M. Sultanova M. K. Salakhutdinova U. J. Ishimov J. F. Ziyavitdinov O. N. Veshkurova A. S. Turaev Study of the pharmacokinetics of antituberculosis drug Biomairin Фармакокинетика и Фармакодинамика биомайрин изониазид этамбутол рифампицин ацетилизониазид biomayrin isoniazid ethambutol rifampicin acetylisoniazid |
| title | Study of the pharmacokinetics of antituberculosis drug Biomairin |
| title_full | Study of the pharmacokinetics of antituberculosis drug Biomairin |
| title_fullStr | Study of the pharmacokinetics of antituberculosis drug Biomairin |
| title_full_unstemmed | Study of the pharmacokinetics of antituberculosis drug Biomairin |
| title_short | Study of the pharmacokinetics of antituberculosis drug Biomairin |
| title_sort | study of the pharmacokinetics of antituberculosis drug biomairin |
| topic | биомайрин изониазид этамбутол рифампицин ацетилизониазид biomayrin isoniazid ethambutol rifampicin acetylisoniazid |
| url | https://www.pharmacokinetica.ru/jour/article/view/76 |
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