In vitro and in vivo activity of a novel locked nucleic acid (LNA)-inhibitor-miR-221 against multiple myeloma cells.

In vitro and in vivo activity of a novel locked nucleic acid (LNA)-inhibitor-miR-221 against multiple myeloma cells.

<h4>Background & aim</h4>The miR-221/222 cluster is upregulated in malignant plasma cells from multiple myeloma (MM) patients harboring the t(4;14) translocation. We previously reported that silencing of miR-221/222 by an antisense oligonucleotide induces anti-MM activity and upregul...

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Main Authors: Maria Teresa Di Martino, Annamaria Gullà, Maria Eugenia Gallo Cantafio, Emanuela Altomare, Nicola Amodio, Emanuela Leone, Eugenio Morelli, Santo Giovanni Lio, Daniele Caracciolo, Marco Rossi, Niels M Frandsen, Pierosandro Tagliaferri, Pierfrancesco Tassone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089659&type=printable
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