Spectroscopic, Electrochemical, and In Silico Characterization of Complex Formed between 2-Ferrocenylbenzoic Acid and DNA
We present the synthesis of 2-ferrocenylbenzoic acid (FcOH) and its electrochemical and spectroscopic characterization. FcOH was characterized for interaction with DNA using theoretical and experimental methods. UV-visible spectroscopy and cyclic voltammeter (CV) were used for the experimental accou...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/7468951 |
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| author | Ataf Ali Altaf Bhajan Lal Nasir Khan Amin Badshah Shafiq Ullah Kamran Akbar |
| author_facet | Ataf Ali Altaf Bhajan Lal Nasir Khan Amin Badshah Shafiq Ullah Kamran Akbar |
| author_sort | Ataf Ali Altaf |
| collection | DOAJ |
| description | We present the synthesis of 2-ferrocenylbenzoic acid (FcOH) and its electrochemical and spectroscopic characterization. FcOH was characterized for interaction with DNA using theoretical and experimental methods. UV-visible spectroscopy and cyclic voltammeter (CV) were used for the experimental account of FcOH-DNA complex. The experimental results showed that the FcOH interacts by electrostatic mode. The binding constant (Kb) and Gibbs free energy (ΔG) for the FcOH-DNA complex have been estimated as 5.3 × 104 M−1 and −6.44 kcal/mol, respectively. The theoretical DNA binding of FcOH was studied with AutoDock molecular docking software. The docking studies yield good approximation with experimental data and explain the sites of binding. |
| format | Article |
| id | doaj-art-598402703e264b45af5941a80026c85d |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-598402703e264b45af5941a80026c85d2025-02-03T01:12:12ZengWileyJournal of Chemistry2090-90632090-90712016-01-01201610.1155/2016/74689517468951Spectroscopic, Electrochemical, and In Silico Characterization of Complex Formed between 2-Ferrocenylbenzoic Acid and DNAAtaf Ali Altaf0Bhajan Lal1Nasir Khan2Amin Badshah3Shafiq Ullah4Kamran Akbar5Department of Chemistry, University of Gujrat, Hafiz Hayat Campus, Jalalpur Jattan Road, Gujrat 50700, PakistanDepartment of Energy System Engineering, Sukkur Institute of Business Administration, Sukkur 65200, PakistanDepartment of Chemistry, Quaid-i-Azam University, Islamabad 45320, PakistanDepartment of Chemistry, Quaid-i-Azam University, Islamabad 45320, PakistanDepartment of Chemistry, Quaid-i-Azam University, Islamabad 45320, PakistanGraphene Research Institute, Sejong University, Seoul, Republic of KoreaWe present the synthesis of 2-ferrocenylbenzoic acid (FcOH) and its electrochemical and spectroscopic characterization. FcOH was characterized for interaction with DNA using theoretical and experimental methods. UV-visible spectroscopy and cyclic voltammeter (CV) were used for the experimental account of FcOH-DNA complex. The experimental results showed that the FcOH interacts by electrostatic mode. The binding constant (Kb) and Gibbs free energy (ΔG) for the FcOH-DNA complex have been estimated as 5.3 × 104 M−1 and −6.44 kcal/mol, respectively. The theoretical DNA binding of FcOH was studied with AutoDock molecular docking software. The docking studies yield good approximation with experimental data and explain the sites of binding.http://dx.doi.org/10.1155/2016/7468951 |
| spellingShingle | Ataf Ali Altaf Bhajan Lal Nasir Khan Amin Badshah Shafiq Ullah Kamran Akbar Spectroscopic, Electrochemical, and In Silico Characterization of Complex Formed between 2-Ferrocenylbenzoic Acid and DNA Journal of Chemistry |
| title | Spectroscopic, Electrochemical, and In Silico Characterization of Complex Formed between 2-Ferrocenylbenzoic Acid and DNA |
| title_full | Spectroscopic, Electrochemical, and In Silico Characterization of Complex Formed between 2-Ferrocenylbenzoic Acid and DNA |
| title_fullStr | Spectroscopic, Electrochemical, and In Silico Characterization of Complex Formed between 2-Ferrocenylbenzoic Acid and DNA |
| title_full_unstemmed | Spectroscopic, Electrochemical, and In Silico Characterization of Complex Formed between 2-Ferrocenylbenzoic Acid and DNA |
| title_short | Spectroscopic, Electrochemical, and In Silico Characterization of Complex Formed between 2-Ferrocenylbenzoic Acid and DNA |
| title_sort | spectroscopic electrochemical and in silico characterization of complex formed between 2 ferrocenylbenzoic acid and dna |
| url | http://dx.doi.org/10.1155/2016/7468951 |
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