Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.

Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.

<h4>Background</h4>Converging evidence suggests that immune-mediated dysfunction plays an important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic studies have shown that immune-associated loci are associated with increased FTD risk, a systematic investigatio...

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Main Authors: Iris Broce, Celeste M Karch, Natalie Wen, Chun C Fan, Yunpeng Wang, Chin Hong Tan, Naomi Kouri, Owen A Ross, Günter U Höglinger, Ulrich Muller, John Hardy, International FTD-Genomics Consortium, Parastoo Momeni, Christopher P Hess, William P Dillon, Zachary A Miller, Luke W Bonham, Gil D Rabinovici, Howard J Rosen, Gerard D Schellenberg, Andre Franke, Tom H Karlsen, Jan H Veldink, Raffaele Ferrari, Jennifer S Yokoyama, Bruce L Miller, Ole A Andreassen, Anders M Dale, Rahul S Desikan, Leo P Sugrue
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1002487
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