The interplay between endoplasmic reticulum stress and inflammation in multiple sclerosis
Abstract Endoplasmic reticulum (ER) stress is one of the hallmarks of neurodegenerative diseases. This study aimed to investigate the role of ER stress in interaction with inflammatory markers in patients with multiple sclerosis (MS). The participants in the current study were recruited in two age a...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-06996-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849238849273724928 |
|---|---|
| author | Zhila Maghbooli Forough Azam Sayahpour Tarlan Varzandi Mahya Rouhollahi Masoumi Mohammad Ali Sahraian |
| author_facet | Zhila Maghbooli Forough Azam Sayahpour Tarlan Varzandi Mahya Rouhollahi Masoumi Mohammad Ali Sahraian |
| author_sort | Zhila Maghbooli |
| collection | DOAJ |
| description | Abstract Endoplasmic reticulum (ER) stress is one of the hallmarks of neurodegenerative diseases. This study aimed to investigate the role of ER stress in interaction with inflammatory markers in patients with multiple sclerosis (MS). The participants in the current study were recruited in two age and sex-matched groups: 44 recently diagnosed MS patients and 53 control subjects. Differential gene expression of C/EBP homologous protein (CHOP), 78-kDa glucose-regulated protein (GRP78), and circulating levels of interleukin (IL)-1β and tumor necrosis factor (TNF-α) were assessed in MS patients and controls. The results showed that serum levels of TNF-α were significantly higher in MS patients than in the control group (p = 0.01), but not IL-1β serum levels. As for ER stress markers, there were no changes in CHOP expression levels in MS patients compared to the control group (p = 0.2). In contrast, GRP78 showed significant upregulation in MS patients compared to the control group (p = 0.0001). This study showed that the interaction between GRP78 and TNF-α influences the risk of MS (beta = 1.43, 95%CI:1.09–1.87, p = 0.01). Our data suggest that the interaction between TNF-α and GRP78 may modulate ER stress in MS patients. |
| format | Article |
| id | doaj-art-597f2a112cd84e18af010f42f2498a3f |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-597f2a112cd84e18af010f42f2498a3f2025-08-20T04:01:24ZengNature PortfolioScientific Reports2045-23222025-07-011511810.1038/s41598-025-06996-6The interplay between endoplasmic reticulum stress and inflammation in multiple sclerosisZhila Maghbooli0Forough Azam Sayahpour1Tarlan Varzandi2Mahya Rouhollahi Masoumi3Mohammad Ali Sahraian4Multiple Sclerosis Research Center, Neurosciences Institute, Tehran University of Medical SciencesDepartment of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECRMultiple Sclerosis Research Center, Neurosciences Institute, Tehran University of Medical SciencesDepartment of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECRMultiple Sclerosis Research Center, Neurosciences Institute, Tehran University of Medical SciencesAbstract Endoplasmic reticulum (ER) stress is one of the hallmarks of neurodegenerative diseases. This study aimed to investigate the role of ER stress in interaction with inflammatory markers in patients with multiple sclerosis (MS). The participants in the current study were recruited in two age and sex-matched groups: 44 recently diagnosed MS patients and 53 control subjects. Differential gene expression of C/EBP homologous protein (CHOP), 78-kDa glucose-regulated protein (GRP78), and circulating levels of interleukin (IL)-1β and tumor necrosis factor (TNF-α) were assessed in MS patients and controls. The results showed that serum levels of TNF-α were significantly higher in MS patients than in the control group (p = 0.01), but not IL-1β serum levels. As for ER stress markers, there were no changes in CHOP expression levels in MS patients compared to the control group (p = 0.2). In contrast, GRP78 showed significant upregulation in MS patients compared to the control group (p = 0.0001). This study showed that the interaction between GRP78 and TNF-α influences the risk of MS (beta = 1.43, 95%CI:1.09–1.87, p = 0.01). Our data suggest that the interaction between TNF-α and GRP78 may modulate ER stress in MS patients.https://doi.org/10.1038/s41598-025-06996-6Multiple sclerosisEndoplasmic reticulumGRP78TNF-α |
| spellingShingle | Zhila Maghbooli Forough Azam Sayahpour Tarlan Varzandi Mahya Rouhollahi Masoumi Mohammad Ali Sahraian The interplay between endoplasmic reticulum stress and inflammation in multiple sclerosis Scientific Reports Multiple sclerosis Endoplasmic reticulum GRP78 TNF-α |
| title | The interplay between endoplasmic reticulum stress and inflammation in multiple sclerosis |
| title_full | The interplay between endoplasmic reticulum stress and inflammation in multiple sclerosis |
| title_fullStr | The interplay between endoplasmic reticulum stress and inflammation in multiple sclerosis |
| title_full_unstemmed | The interplay between endoplasmic reticulum stress and inflammation in multiple sclerosis |
| title_short | The interplay between endoplasmic reticulum stress and inflammation in multiple sclerosis |
| title_sort | interplay between endoplasmic reticulum stress and inflammation in multiple sclerosis |
| topic | Multiple sclerosis Endoplasmic reticulum GRP78 TNF-α |
| url | https://doi.org/10.1038/s41598-025-06996-6 |
| work_keys_str_mv | AT zhilamaghbooli theinterplaybetweenendoplasmicreticulumstressandinflammationinmultiplesclerosis AT foroughazamsayahpour theinterplaybetweenendoplasmicreticulumstressandinflammationinmultiplesclerosis AT tarlanvarzandi theinterplaybetweenendoplasmicreticulumstressandinflammationinmultiplesclerosis AT mahyarouhollahimasoumi theinterplaybetweenendoplasmicreticulumstressandinflammationinmultiplesclerosis AT mohammadalisahraian theinterplaybetweenendoplasmicreticulumstressandinflammationinmultiplesclerosis AT zhilamaghbooli interplaybetweenendoplasmicreticulumstressandinflammationinmultiplesclerosis AT foroughazamsayahpour interplaybetweenendoplasmicreticulumstressandinflammationinmultiplesclerosis AT tarlanvarzandi interplaybetweenendoplasmicreticulumstressandinflammationinmultiplesclerosis AT mahyarouhollahimasoumi interplaybetweenendoplasmicreticulumstressandinflammationinmultiplesclerosis AT mohammadalisahraian interplaybetweenendoplasmicreticulumstressandinflammationinmultiplesclerosis |