Hydrogen sulfide mitigates the immunotoxicity and neurotoxicity induced by cadmium in Tegillarca granosa
The blood clam Tegilarca granosa is an economically important shellfish in Asia. The complex living environment often exposes the clams to cadmium (Cd) and hydrogen sulfide (H2S). H2S is well-known for its toxic effects, however, it is still unclear whether it can participate in regulating the heavy...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132500630X |
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| Summary: | The blood clam Tegilarca granosa is an economically important shellfish in Asia. The complex living environment often exposes the clams to cadmium (Cd) and hydrogen sulfide (H2S). H2S is well-known for its toxic effects, however, it is still unclear whether it can participate in regulating the heavy metal adaptation in clams. Here, we subjected T. granosa to chronic Cd stress (50 μg/L, 14 days) to explore their physiological and molecular response patterns under the addition of 0.2, 0.4, and 0.8 mM H2S. The results indicated that the Cd stress induced the immune-toxicity and neurotoxicity in the gills and viscera. H2S could alleviate the toxicity by inducing phagocytosis rate, maintaining AChE and Ca2 +- ATPase activities, reducing MDA and O2- contents, promoting the excretion or degradation of Cd, and inhibiting the Ca2+ signaling pathway (CaM, CaMK2, CaMKK2). However, high concentrations of H2S also inhibited the ATPase activities and the apoptotic signaling pathway. Altogether, our results indicated that H2S has a special regulatory mechanism for Cd toxicity in the clam T. granosa, and this regulation may depend on the Ca2+ signaling pathway. Our results would offer insights into the sulfide and Cd - tolerant molecular mechanisms in this species and provide a useful tool for assessing the integrated biological impacts of Cd and sulfide on shellfish. |
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| ISSN: | 0147-6513 |