Prevalence and determinants of nasal carriage of penicillin non-susceptible Streptococcus pneumoniae: a cross-sectional household survey in northern VietnamResearch in context
Summary: Background: Beta-lactams remain the first-line treatment of Streptococcus pneumoniae infections despite the increasing global prevalence of penicillin-resistant/non-susceptible strains. We conducted a cross-sectional household survey in a rural community in northern Vietnam in 2018–2019 to...
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Elsevier
2025-01-01
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| Series: | The Lancet Regional Health. Western Pacific |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666606524002761 |
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| author | Costanza Tacoli Hien Anh Thi Nguyen Tu Cam Thi Nguyen Bich Ngoc Thi Vu Max van Wijk Quynh Dieu Pham Huong Kieu Thi Tran Thuong Hong Thi Nguyen Trang Thu Nguyen Tung Son Trinh Dung Tien Viet Vu Hoang Huy Tran Thai Duy Pham Duc Anh Dang Tien Dac Tran Duong Thanh Nguyen H. Rogier van Doorn Thomas Kesteman Sonia Lewycka |
| author_facet | Costanza Tacoli Hien Anh Thi Nguyen Tu Cam Thi Nguyen Bich Ngoc Thi Vu Max van Wijk Quynh Dieu Pham Huong Kieu Thi Tran Thuong Hong Thi Nguyen Trang Thu Nguyen Tung Son Trinh Dung Tien Viet Vu Hoang Huy Tran Thai Duy Pham Duc Anh Dang Tien Dac Tran Duong Thanh Nguyen H. Rogier van Doorn Thomas Kesteman Sonia Lewycka |
| author_sort | Costanza Tacoli |
| collection | DOAJ |
| description | Summary: Background: Beta-lactams remain the first-line treatment of Streptococcus pneumoniae infections despite the increasing global prevalence of penicillin-resistant/non-susceptible strains. We conducted a cross-sectional household survey in a rural community in northern Vietnam in 2018–2019 to provide prevalence estimates of penicillin non-susceptible S. pneumoniae (PNSP) carriage and to investigate behavioural and environmental factors associated with PNSP colonization. The data presented will inform the design of a large trial of population-based interventions targeting inappropriate antibiotic use. Methods: A survey was conducted between July 2018 and April 2019, encompassing 1502 individuals from 324 households. A total of 1, 498 samples from nasal and nasopharyngeal swabs were cultured on blood agar plates supplemented with 5 μg of gentamicin. S. pneumoniae colonies were confirmed by MALDI-TOF. Penicillin susceptibility was tested by E-test. Logistic regression models were used to explore risk factors for PNSP carriage compared to susceptible strains. Findings: We recovered 132 S. pneumoniae isolates out of 1148 swabs. Antibiotic susceptibility results were obtained for 97% (128/132). Of these, 76% (97/128) were PNSP (MIC ≥ 0.12 μg/ml) and 77% (99/128) were non-susceptible to three or more antibiotics. After adjusting for age and wealth, antibiotic use was not associated with PNSP carriage. Participants more likely to be colonized with PNSP were young (≤20-years) and more frequently ate meat and dairy products, particularly pork (adjusted OR 52.30 [95% CI 8.72–313.60]) and milk derivatives (aOR 12.48 [4.01–38.82]). Consumption of fermented food was a protective factor (aOR, 0.02 [<0.01–0.13)]. Interpretation: The prevalence of PNSP was high, but not associated with individual antibiotic use. Community-level interventions to reduce antibiotic consumption are urgently needed, as well as further investigations on antibiotic residues in food products to assess their role in the emergence and prevalence of PNSP. Funding: This work was supported by Oxford University Clinical Research Unit internal grants from the Wellcome Trust Africa Asia Programme core grants (2015-2022—106680/Z/14/Z and 2022-2029—2022-2029—225167/Z/22/Z). |
| format | Article |
| id | doaj-art-59762fdfe48f41e195957f7d5f1b810f |
| institution | Kabale University |
| issn | 2666-6065 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | The Lancet Regional Health. Western Pacific |
| spelling | doaj-art-59762fdfe48f41e195957f7d5f1b810f2025-01-09T06:14:48ZengElsevierThe Lancet Regional Health. Western Pacific2666-60652025-01-0154101282Prevalence and determinants of nasal carriage of penicillin non-susceptible Streptococcus pneumoniae: a cross-sectional household survey in northern VietnamResearch in contextCostanza Tacoli0Hien Anh Thi Nguyen1Tu Cam Thi Nguyen2Bich Ngoc Thi Vu3Max van Wijk4Quynh Dieu Pham5Huong Kieu Thi Tran6Thuong Hong Thi Nguyen7Trang Thu Nguyen8Tung Son Trinh9Dung Tien Viet Vu10Hoang Huy Tran11Thai Duy Pham12Duc Anh Dang13Tien Dac Tran14Duong Thanh Nguyen15H. Rogier van Doorn16Thomas Kesteman17Sonia Lewycka18Oxford University Clinical Research Unit (OUCRU), National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da District, Hanoi, Viet NamNational Institute of Hygiene and Epidemiology (NIHE), 1 Yec Xanh, Hanoi, Pham Dinh Ho, Hai Ba Trung, Viet NamOxford University Clinical Research Unit (OUCRU), National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da District, Hanoi, Viet NamOxford University Clinical Research Unit (OUCRU), National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da District, Hanoi, Viet NamOxford University Clinical Research Unit (OUCRU), National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da District, Hanoi, Viet Nam; Faculty de Pharmacy – University of Tours, Tours, FranceOxford University Clinical Research Unit (OUCRU), National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da District, Hanoi, Viet NamOxford University Clinical Research Unit (OUCRU), National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da District, Hanoi, Viet NamOxford University Clinical Research Unit (OUCRU), National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da District, Hanoi, Viet NamOxford University Clinical Research Unit (OUCRU), National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da District, Hanoi, Viet NamOxford University Clinical Research Unit (OUCRU), National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da District, Hanoi, Viet NamOxford University Clinical Research Unit (OUCRU), National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da District, Hanoi, Viet NamNational Institute of Hygiene and Epidemiology (NIHE), 1 Yec Xanh, Hanoi, Pham Dinh Ho, Hai Ba Trung, Viet NamNational Institute of Hygiene and Epidemiology (NIHE), 1 Yec Xanh, Hanoi, Pham Dinh Ho, Hai Ba Trung, Viet NamFaculty de Pharmacy – University of Tours, Tours, FranceCentre for Disease Control, Ha Nam Province, Viet Nam; Department of Health, Ha Nam Province, Viet NamCentre for Disease Control, Ha Nam Province, Viet NamOxford University Clinical Research Unit (OUCRU), National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da District, Hanoi, Viet Nam; Centre of Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, New Richards Building, Roosevelt Dr, Headington, Oxford OX3 7LG, United KingdomOxford University Clinical Research Unit (OUCRU), National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da District, Hanoi, Viet Nam; Centre of Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, New Richards Building, Roosevelt Dr, Headington, Oxford OX3 7LG, United KingdomOxford University Clinical Research Unit (OUCRU), National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da District, Hanoi, Viet Nam; Centre of Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, New Richards Building, Roosevelt Dr, Headington, Oxford OX3 7LG, United Kingdom; Corresponding author. Oxford University Clinical Research Unit (OUCRU), National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da District, Hanoi, Viet Nam.Summary: Background: Beta-lactams remain the first-line treatment of Streptococcus pneumoniae infections despite the increasing global prevalence of penicillin-resistant/non-susceptible strains. We conducted a cross-sectional household survey in a rural community in northern Vietnam in 2018–2019 to provide prevalence estimates of penicillin non-susceptible S. pneumoniae (PNSP) carriage and to investigate behavioural and environmental factors associated with PNSP colonization. The data presented will inform the design of a large trial of population-based interventions targeting inappropriate antibiotic use. Methods: A survey was conducted between July 2018 and April 2019, encompassing 1502 individuals from 324 households. A total of 1, 498 samples from nasal and nasopharyngeal swabs were cultured on blood agar plates supplemented with 5 μg of gentamicin. S. pneumoniae colonies were confirmed by MALDI-TOF. Penicillin susceptibility was tested by E-test. Logistic regression models were used to explore risk factors for PNSP carriage compared to susceptible strains. Findings: We recovered 132 S. pneumoniae isolates out of 1148 swabs. Antibiotic susceptibility results were obtained for 97% (128/132). Of these, 76% (97/128) were PNSP (MIC ≥ 0.12 μg/ml) and 77% (99/128) were non-susceptible to three or more antibiotics. After adjusting for age and wealth, antibiotic use was not associated with PNSP carriage. Participants more likely to be colonized with PNSP were young (≤20-years) and more frequently ate meat and dairy products, particularly pork (adjusted OR 52.30 [95% CI 8.72–313.60]) and milk derivatives (aOR 12.48 [4.01–38.82]). Consumption of fermented food was a protective factor (aOR, 0.02 [<0.01–0.13)]. Interpretation: The prevalence of PNSP was high, but not associated with individual antibiotic use. Community-level interventions to reduce antibiotic consumption are urgently needed, as well as further investigations on antibiotic residues in food products to assess their role in the emergence and prevalence of PNSP. Funding: This work was supported by Oxford University Clinical Research Unit internal grants from the Wellcome Trust Africa Asia Programme core grants (2015-2022—106680/Z/14/Z and 2022-2029—2022-2029—225167/Z/22/Z).http://www.sciencedirect.com/science/article/pii/S2666606524002761AntibioticResistancePenicillinStreptococcus pneumoniaeCommensalCarriage |
| spellingShingle | Costanza Tacoli Hien Anh Thi Nguyen Tu Cam Thi Nguyen Bich Ngoc Thi Vu Max van Wijk Quynh Dieu Pham Huong Kieu Thi Tran Thuong Hong Thi Nguyen Trang Thu Nguyen Tung Son Trinh Dung Tien Viet Vu Hoang Huy Tran Thai Duy Pham Duc Anh Dang Tien Dac Tran Duong Thanh Nguyen H. Rogier van Doorn Thomas Kesteman Sonia Lewycka Prevalence and determinants of nasal carriage of penicillin non-susceptible Streptococcus pneumoniae: a cross-sectional household survey in northern VietnamResearch in context The Lancet Regional Health. Western Pacific Antibiotic Resistance Penicillin Streptococcus pneumoniae Commensal Carriage |
| title | Prevalence and determinants of nasal carriage of penicillin non-susceptible Streptococcus pneumoniae: a cross-sectional household survey in northern VietnamResearch in context |
| title_full | Prevalence and determinants of nasal carriage of penicillin non-susceptible Streptococcus pneumoniae: a cross-sectional household survey in northern VietnamResearch in context |
| title_fullStr | Prevalence and determinants of nasal carriage of penicillin non-susceptible Streptococcus pneumoniae: a cross-sectional household survey in northern VietnamResearch in context |
| title_full_unstemmed | Prevalence and determinants of nasal carriage of penicillin non-susceptible Streptococcus pneumoniae: a cross-sectional household survey in northern VietnamResearch in context |
| title_short | Prevalence and determinants of nasal carriage of penicillin non-susceptible Streptococcus pneumoniae: a cross-sectional household survey in northern VietnamResearch in context |
| title_sort | prevalence and determinants of nasal carriage of penicillin non susceptible streptococcus pneumoniae a cross sectional household survey in northern vietnamresearch in context |
| topic | Antibiotic Resistance Penicillin Streptococcus pneumoniae Commensal Carriage |
| url | http://www.sciencedirect.com/science/article/pii/S2666606524002761 |
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