Dopamine transporter imaging in clinically unclear cases of parkinsonism and the importance of Scans Without Evidence of Dopaminergic Deficit (SWEDDs)
The clinical diagnosis of Parkinson's disease (PD) is susceptible to misdiagnosis, especially in the earlier stages of the disease. Recently, in vivo imaging techniques assessing the presynaptic dopamine transporter (DAT) have emerged as a useful tool in PD diagnosis, improving its accuracy. OB...
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Thieme Revinter Publicações
2012-09-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000900004&lng=en&tlng=en |
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| author | Marco A. T. Utiumi André C. Felício Conrado R. Borges Vera L. Braatz Sheyla A. S. Rezende Renato P. Munhoz Rodrigo A. Bressan Henrique B. Ferraz Hélio A. G. Teive |
| author_facet | Marco A. T. Utiumi André C. Felício Conrado R. Borges Vera L. Braatz Sheyla A. S. Rezende Renato P. Munhoz Rodrigo A. Bressan Henrique B. Ferraz Hélio A. G. Teive |
| author_sort | Marco A. T. Utiumi |
| collection | DOAJ |
| description | The clinical diagnosis of Parkinson's disease (PD) is susceptible to misdiagnosis, especially in the earlier stages of the disease. Recently, in vivo imaging techniques assessing the presynaptic dopamine transporter (DAT) have emerged as a useful tool in PD diagnosis, improving its accuracy. OBJECTIVE: It was to illustrate the clinical usefulness of a brain single-photon emission computed tomography (SPECT) DAT ligand, and highlight relevant aspects of scans without evidence of dopaminergic deficit (SWEDDs) in this context. CASES: We described four representative patients with clinically unclear parkinsonian syndromes who underwent [99mTc]-TRODAT-1 SPECT and reviewed the clinical implications. CONCLUSION: DAT-SPECT is an important, cost-effective, technique for the differential diagnosis of parkinsonian syndromes. Additionally, SWEDD cases present clinical and paraclinical peculiarities that may retrospectively identify them as essential/dystonic tremor. The lack of histopathological data limits further conclusions. |
| format | Article |
| id | doaj-art-59707e1f4fd3416dab84b4f3afd451f0 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2012-09-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-59707e1f4fd3416dab84b4f3afd451f02025-08-20T02:05:33ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272012-09-0170966767310.1590/S0004-282X2012000900004S0004-282X2012000900004Dopamine transporter imaging in clinically unclear cases of parkinsonism and the importance of Scans Without Evidence of Dopaminergic Deficit (SWEDDs)Marco A. T. Utiumi0André C. Felício1Conrado R. Borges2Vera L. Braatz3Sheyla A. S. Rezende4Renato P. Munhoz5Rodrigo A. Bressan6Henrique B. Ferraz7Hélio A. G. Teive8Universidade Federal do ParanáUniversidade Federal de São PauloUniversidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal do ParanáThe clinical diagnosis of Parkinson's disease (PD) is susceptible to misdiagnosis, especially in the earlier stages of the disease. Recently, in vivo imaging techniques assessing the presynaptic dopamine transporter (DAT) have emerged as a useful tool in PD diagnosis, improving its accuracy. OBJECTIVE: It was to illustrate the clinical usefulness of a brain single-photon emission computed tomography (SPECT) DAT ligand, and highlight relevant aspects of scans without evidence of dopaminergic deficit (SWEDDs) in this context. CASES: We described four representative patients with clinically unclear parkinsonian syndromes who underwent [99mTc]-TRODAT-1 SPECT and reviewed the clinical implications. CONCLUSION: DAT-SPECT is an important, cost-effective, technique for the differential diagnosis of parkinsonian syndromes. Additionally, SWEDD cases present clinical and paraclinical peculiarities that may retrospectively identify them as essential/dystonic tremor. The lack of histopathological data limits further conclusions.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000900004&lng=en&tlng=endoença de Parkinsonexames sem evidência de déficit dopaminérgicotomografia computadorizada de emissão de fóton únicoTc-99m-trodat-1transportador de dopamina |
| spellingShingle | Marco A. T. Utiumi André C. Felício Conrado R. Borges Vera L. Braatz Sheyla A. S. Rezende Renato P. Munhoz Rodrigo A. Bressan Henrique B. Ferraz Hélio A. G. Teive Dopamine transporter imaging in clinically unclear cases of parkinsonism and the importance of Scans Without Evidence of Dopaminergic Deficit (SWEDDs) Arquivos de Neuro-Psiquiatria doença de Parkinson exames sem evidência de déficit dopaminérgico tomografia computadorizada de emissão de fóton único Tc-99m-trodat-1 transportador de dopamina |
| title | Dopamine transporter imaging in clinically unclear cases of parkinsonism and the importance of Scans Without Evidence of Dopaminergic Deficit (SWEDDs) |
| title_full | Dopamine transporter imaging in clinically unclear cases of parkinsonism and the importance of Scans Without Evidence of Dopaminergic Deficit (SWEDDs) |
| title_fullStr | Dopamine transporter imaging in clinically unclear cases of parkinsonism and the importance of Scans Without Evidence of Dopaminergic Deficit (SWEDDs) |
| title_full_unstemmed | Dopamine transporter imaging in clinically unclear cases of parkinsonism and the importance of Scans Without Evidence of Dopaminergic Deficit (SWEDDs) |
| title_short | Dopamine transporter imaging in clinically unclear cases of parkinsonism and the importance of Scans Without Evidence of Dopaminergic Deficit (SWEDDs) |
| title_sort | dopamine transporter imaging in clinically unclear cases of parkinsonism and the importance of scans without evidence of dopaminergic deficit swedds |
| topic | doença de Parkinson exames sem evidência de déficit dopaminérgico tomografia computadorizada de emissão de fóton único Tc-99m-trodat-1 transportador de dopamina |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000900004&lng=en&tlng=en |
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