Comprehensive genome-scale CRISPR knockout screening of CHO cells

Comprehensive genome-scale CRISPR knockout screening of CHO cells

Abstract Chinese hamster ovary (CHO) cells play a pivotal role in the production of recombinant therapeutics. In the present study, we conducted a genome-scale pooled CRISPR knockout (KO) screening using a virus-free, recombinase-mediated cassette exchange-based platform in CHO-K1 host and CHO-K1 de...

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Bibliographic Details
Main Authors: Sung Wook Shin, Su Hyun Kim, Aghiles Gasselin, Gyun Min Lee, Jae Seong Lee
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Data
Online Access:https://doi.org/10.1038/s41597-025-04438-6
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