Effectiveness of <i>Bacillus clausii</i> (O/C, N/R, SIN, T) in the Prevention of Antibiotic-Associated Diarrhea and Gastrointestinal Symptoms: A Systematic Review
<b>Background</b>: Dysbiosis and antibiotic-associated diarrhea (AAD) are significant concerns in clinical settings. Probiotics, such as <i>Bacillus clausii</i> (O/C, N/R, SIN, T), a spore-forming bacterium resistant to gastrointestinal conditions and most commonly used antib...
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MDPI AG
2025-04-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/14/5/439 |
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| author | Ana Teresa Abreu Rodrigo Vázquez Frías Christian Boggio Marzet Juan Pablo Stefanolo Alejandro Concha Mejía Luis Bustos Fernández Oscar Laudanno Dimas Rosa Maria Claudia Cruz Serrano Karen Cárdenas Julio Zuluaga |
| author_facet | Ana Teresa Abreu Rodrigo Vázquez Frías Christian Boggio Marzet Juan Pablo Stefanolo Alejandro Concha Mejía Luis Bustos Fernández Oscar Laudanno Dimas Rosa Maria Claudia Cruz Serrano Karen Cárdenas Julio Zuluaga |
| author_sort | Ana Teresa Abreu |
| collection | DOAJ |
| description | <b>Background</b>: Dysbiosis and antibiotic-associated diarrhea (AAD) are significant concerns in clinical settings. Probiotics, such as <i>Bacillus clausii</i> (O/C, N/R, SIN, T), a spore-forming bacterium resistant to gastrointestinal conditions and most commonly used antibiotics, emerge as a promising approach. We aim to assess the role of <i>B. clausii</i> in preventing AAD in children and adults during antibiotic therapy. <b>Materials and methods</b>: A systematic literature search was conducted across multiple databases, including MEDLINE, EMBASE, Cochrane Library, LILACS, and SciELO, up to May 2024. Studies were included if they involved <i>B. clausii</i> (O/C, N/R, SIN, T) administration during antibiotic treatment and reported AAD-related outcomes. <b>Results</b>: A total of four studies were included in the review. The studies comprised two randomized controlled trials (RCTs), one meta-analysis of RCTs, and one expert consensus. The primary outcome was the effectiveness of <i>B. clausii</i> (O/C, N/R, SIN, T) in reducing the incidence of diarrhea. Results showed a significant reduction in the risk of AAD and gastrointestinal symptoms in patients receiving it at a dosage of 4 × 10<sup>9</sup> CFU/day for children and 6 × 10<sup>9</sup> CFU/day for adolescents and adults for up to 14 days. <b>Conclusions</b>: <i>B. clausii</i> (O/C, N/R, SIN, T) appears to be an effective probiotic for preventing AAD in adults and children. It significantly improves gastrointestinal symptoms associated with antibiotic treatment, including diarrhea, nausea, and epigastric pain. Future studies are recommended to further elucidate its effectiveness in diverse populations, especially in low- and middle-income countries. |
| format | Article |
| id | doaj-art-596c19e3ec824c329f0bce20b10d4214 |
| institution | DOAJ |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Antibiotics |
| spelling | doaj-art-596c19e3ec824c329f0bce20b10d42142025-08-20T03:14:32ZengMDPI AGAntibiotics2079-63822025-04-0114543910.3390/antibiotics14050439Effectiveness of <i>Bacillus clausii</i> (O/C, N/R, SIN, T) in the Prevention of Antibiotic-Associated Diarrhea and Gastrointestinal Symptoms: A Systematic ReviewAna Teresa Abreu0Rodrigo Vázquez Frías1Christian Boggio Marzet2Juan Pablo Stefanolo3Alejandro Concha Mejía4Luis Bustos Fernández5Oscar Laudanno6Dimas Rosa7Maria Claudia Cruz Serrano8Karen Cárdenas9Julio Zuluaga10Hospital Angeles del Pedregal, Mexico City 10700, MexicoHospital Infantil de México Federico Gómez, Mexico City 06720, MexicoGrupo de Trabajo en Gastroenterología y Nutrición Pediátrica, Hospital Gral. de Agudos “Dr. I. Pirovano”, Buenos Aires C1428, ArgentinaNeurogastroenterology Laboratory, Favaloro Foundation–University Hospital, Buenos Aires C1095, ArgentinaClínica del Country, Clínica la Colina, Hospital Universitario Nacional de Colombia, Universidad Nacional de Colombia, Bogotá 111321, ColombiaCentro Médico Dr. Bustos Fernández, Buenos Aires C1428, ArgentinaInstituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires C1427, ArgentinaGrupo de Investigación del Caribe y Centroamérica para la Microbiota, Probióticos y Prebióticos GICCAMPP, Santa Marta 470001, ColombiaOpella, a Sanofi Company, Bogotá 110121, ColombiaOdds Epidemiology, Bogotá 111321, ColombiaOdds Epidemiology, Bogotá 111321, Colombia<b>Background</b>: Dysbiosis and antibiotic-associated diarrhea (AAD) are significant concerns in clinical settings. Probiotics, such as <i>Bacillus clausii</i> (O/C, N/R, SIN, T), a spore-forming bacterium resistant to gastrointestinal conditions and most commonly used antibiotics, emerge as a promising approach. We aim to assess the role of <i>B. clausii</i> in preventing AAD in children and adults during antibiotic therapy. <b>Materials and methods</b>: A systematic literature search was conducted across multiple databases, including MEDLINE, EMBASE, Cochrane Library, LILACS, and SciELO, up to May 2024. Studies were included if they involved <i>B. clausii</i> (O/C, N/R, SIN, T) administration during antibiotic treatment and reported AAD-related outcomes. <b>Results</b>: A total of four studies were included in the review. The studies comprised two randomized controlled trials (RCTs), one meta-analysis of RCTs, and one expert consensus. The primary outcome was the effectiveness of <i>B. clausii</i> (O/C, N/R, SIN, T) in reducing the incidence of diarrhea. Results showed a significant reduction in the risk of AAD and gastrointestinal symptoms in patients receiving it at a dosage of 4 × 10<sup>9</sup> CFU/day for children and 6 × 10<sup>9</sup> CFU/day for adolescents and adults for up to 14 days. <b>Conclusions</b>: <i>B. clausii</i> (O/C, N/R, SIN, T) appears to be an effective probiotic for preventing AAD in adults and children. It significantly improves gastrointestinal symptoms associated with antibiotic treatment, including diarrhea, nausea, and epigastric pain. Future studies are recommended to further elucidate its effectiveness in diverse populations, especially in low- and middle-income countries.https://www.mdpi.com/2079-6382/14/5/439<i>Bacillus clausii</i>antibiotic-associated diarrheaprobioticsdysbiosissystematic review |
| spellingShingle | Ana Teresa Abreu Rodrigo Vázquez Frías Christian Boggio Marzet Juan Pablo Stefanolo Alejandro Concha Mejía Luis Bustos Fernández Oscar Laudanno Dimas Rosa Maria Claudia Cruz Serrano Karen Cárdenas Julio Zuluaga Effectiveness of <i>Bacillus clausii</i> (O/C, N/R, SIN, T) in the Prevention of Antibiotic-Associated Diarrhea and Gastrointestinal Symptoms: A Systematic Review Antibiotics <i>Bacillus clausii</i> antibiotic-associated diarrhea probiotics dysbiosis systematic review |
| title | Effectiveness of <i>Bacillus clausii</i> (O/C, N/R, SIN, T) in the Prevention of Antibiotic-Associated Diarrhea and Gastrointestinal Symptoms: A Systematic Review |
| title_full | Effectiveness of <i>Bacillus clausii</i> (O/C, N/R, SIN, T) in the Prevention of Antibiotic-Associated Diarrhea and Gastrointestinal Symptoms: A Systematic Review |
| title_fullStr | Effectiveness of <i>Bacillus clausii</i> (O/C, N/R, SIN, T) in the Prevention of Antibiotic-Associated Diarrhea and Gastrointestinal Symptoms: A Systematic Review |
| title_full_unstemmed | Effectiveness of <i>Bacillus clausii</i> (O/C, N/R, SIN, T) in the Prevention of Antibiotic-Associated Diarrhea and Gastrointestinal Symptoms: A Systematic Review |
| title_short | Effectiveness of <i>Bacillus clausii</i> (O/C, N/R, SIN, T) in the Prevention of Antibiotic-Associated Diarrhea and Gastrointestinal Symptoms: A Systematic Review |
| title_sort | effectiveness of i bacillus clausii i o c n r sin t in the prevention of antibiotic associated diarrhea and gastrointestinal symptoms a systematic review |
| topic | <i>Bacillus clausii</i> antibiotic-associated diarrhea probiotics dysbiosis systematic review |
| url | https://www.mdpi.com/2079-6382/14/5/439 |
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