Seroprevalence of strongyloidiasis and toxocariasis among hypereosinophilic patients seeking care at diagnostic centers in Tehran, Iran
Background: Hypereosinophilia is characterized by an increase in eosinophil levels above the normal range. Secondary hypereosinophilia is frequently seen in helminth infections and allergic conditions. If not diagnosed and managed promptly, eosinophilia can result in various complications impacting...
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Elsevier
2024-11-01
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| Series: | Clinical Epidemiology and Global Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213398424003233 |
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| author | Zohre Fakhrieh- Kashan Eshrat Beigom Kia Mohammad Taghi Haghi Ashtiani Seyed Reza Dabaghi Mohammad Amin Sari Enayat Darabi |
| author_facet | Zohre Fakhrieh- Kashan Eshrat Beigom Kia Mohammad Taghi Haghi Ashtiani Seyed Reza Dabaghi Mohammad Amin Sari Enayat Darabi |
| author_sort | Zohre Fakhrieh- Kashan |
| collection | DOAJ |
| description | Background: Hypereosinophilia is characterized by an increase in eosinophil levels above the normal range. Secondary hypereosinophilia is frequently seen in helminth infections and allergic conditions. If not diagnosed and managed promptly, eosinophilia can result in various complications impacting health. The aim of this study was to explore the seroprevalence of Strongyloides stercoralis and Toxocara spp. among hypereosinophilic patients undergoing evaluation at selected diagnostic centers in Tehran. Methods: A comprehensive questionnaire was completed, and a blood sample was collected from each participant. The seropositivity of helminth infections was ascertained through indirect enzyme-linked immunosorbent assay (ELISA) employing commercially procured kits for discerning anti-S. stercoralis and anti-Toxocara spp. IgG antibodies. Statistical analysis was conducted using SPSS 21 software. Results: Of the 135 participants in this study, 61 (45.2 %) were male and 74 (54.8 %) were female. The seropositivity rates for strongyloidiasis and toxocariasis were found to be 9.6 % and 0.74 %, respectively. Among the various underlying medical conditions observed in the participants, Type 2 Diabetes (T2D) was the most prevalent, and it showed a significant association with seropositivity for strongyloidiasis (p < 0.05). Conclusion: The seropositivity for S. stercoralis was higher than that for Toxocara spp.. The significant association between seropositivity for S. stercoralis and diabetes underscores the importance of conducting community-based studies and implementing screening initiatives targeting high-risk populations to assess the seroprevalence of strongyloidiasis. |
| format | Article |
| id | doaj-art-596a52218b7b4f6d89c121f43a918dbe |
| institution | DOAJ |
| issn | 2213-3984 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Epidemiology and Global Health |
| spelling | doaj-art-596a52218b7b4f6d89c121f43a918dbe2025-08-20T02:57:21ZengElsevierClinical Epidemiology and Global Health2213-39842024-11-013010182610.1016/j.cegh.2024.101826Seroprevalence of strongyloidiasis and toxocariasis among hypereosinophilic patients seeking care at diagnostic centers in Tehran, IranZohre Fakhrieh- Kashan0Eshrat Beigom Kia1Mohammad Taghi Haghi Ashtiani2Seyed Reza Dabaghi3Mohammad Amin Sari4Enayat Darabi5Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranDepartment of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranDepartment of Pathology, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Medical Parasitology and Mycology, School of Medicine, Zanjan University of Medical Science, IranDepartment of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranDepartment of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Corresponding author. P.O.Box:1417613151, Tehran, Iran.Background: Hypereosinophilia is characterized by an increase in eosinophil levels above the normal range. Secondary hypereosinophilia is frequently seen in helminth infections and allergic conditions. If not diagnosed and managed promptly, eosinophilia can result in various complications impacting health. The aim of this study was to explore the seroprevalence of Strongyloides stercoralis and Toxocara spp. among hypereosinophilic patients undergoing evaluation at selected diagnostic centers in Tehran. Methods: A comprehensive questionnaire was completed, and a blood sample was collected from each participant. The seropositivity of helminth infections was ascertained through indirect enzyme-linked immunosorbent assay (ELISA) employing commercially procured kits for discerning anti-S. stercoralis and anti-Toxocara spp. IgG antibodies. Statistical analysis was conducted using SPSS 21 software. Results: Of the 135 participants in this study, 61 (45.2 %) were male and 74 (54.8 %) were female. The seropositivity rates for strongyloidiasis and toxocariasis were found to be 9.6 % and 0.74 %, respectively. Among the various underlying medical conditions observed in the participants, Type 2 Diabetes (T2D) was the most prevalent, and it showed a significant association with seropositivity for strongyloidiasis (p < 0.05). Conclusion: The seropositivity for S. stercoralis was higher than that for Toxocara spp.. The significant association between seropositivity for S. stercoralis and diabetes underscores the importance of conducting community-based studies and implementing screening initiatives targeting high-risk populations to assess the seroprevalence of strongyloidiasis.http://www.sciencedirect.com/science/article/pii/S2213398424003233HypereosinophiliaStrongyloides stercoralisToxocara spp.Seropositivity |
| spellingShingle | Zohre Fakhrieh- Kashan Eshrat Beigom Kia Mohammad Taghi Haghi Ashtiani Seyed Reza Dabaghi Mohammad Amin Sari Enayat Darabi Seroprevalence of strongyloidiasis and toxocariasis among hypereosinophilic patients seeking care at diagnostic centers in Tehran, Iran Clinical Epidemiology and Global Health Hypereosinophilia Strongyloides stercoralis Toxocara spp. Seropositivity |
| title | Seroprevalence of strongyloidiasis and toxocariasis among hypereosinophilic patients seeking care at diagnostic centers in Tehran, Iran |
| title_full | Seroprevalence of strongyloidiasis and toxocariasis among hypereosinophilic patients seeking care at diagnostic centers in Tehran, Iran |
| title_fullStr | Seroprevalence of strongyloidiasis and toxocariasis among hypereosinophilic patients seeking care at diagnostic centers in Tehran, Iran |
| title_full_unstemmed | Seroprevalence of strongyloidiasis and toxocariasis among hypereosinophilic patients seeking care at diagnostic centers in Tehran, Iran |
| title_short | Seroprevalence of strongyloidiasis and toxocariasis among hypereosinophilic patients seeking care at diagnostic centers in Tehran, Iran |
| title_sort | seroprevalence of strongyloidiasis and toxocariasis among hypereosinophilic patients seeking care at diagnostic centers in tehran iran |
| topic | Hypereosinophilia Strongyloides stercoralis Toxocara spp. Seropositivity |
| url | http://www.sciencedirect.com/science/article/pii/S2213398424003233 |
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