Correlations of Mas-related G protein-coupled receptor X2 and interleukin in patients with chronic spontaneous urticaria
ObjectiveTo explore the correlations between serum Mas-related G protein-coupled receptor X2 (MRGPRX2), interleukin (IL)-4, IL-5, IL-6, IL-13, IL-23 and IL-33 levels and chronic spontaneous urticaria (CSU). MethodsThe clinical characteristics and laboratory data from 55 patients with CSU and 21 heal...
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Shanghai Chinese Clinical Medicine Press Co., Ltd.
2024-12-01
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| Series: | Zhongguo Linchuang Yixue |
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| Online Access: | https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2024.20240433 |
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| author | Yiqi ZHU Yixin SHAO Duoqin WANG Yanyun SHEN Taiyu JIN Lisi PENG Hui TANG Zijing XIAO |
| author_facet | Yiqi ZHU Yixin SHAO Duoqin WANG Yanyun SHEN Taiyu JIN Lisi PENG Hui TANG Zijing XIAO |
| author_sort | Yiqi ZHU |
| collection | DOAJ |
| description | ObjectiveTo explore the correlations between serum Mas-related G protein-coupled receptor X2 (MRGPRX2), interleukin (IL)-4, IL-5, IL-6, IL-13, IL-23 and IL-33 levels and chronic spontaneous urticaria (CSU). MethodsThe clinical characteristics and laboratory data from 55 patients with CSU and 21 healthy controls at Huashan Hospital, Fudan University from February 2021 to September 2023 were collected. The disease activity and severity of CSU patients were assessed. Serum level of MRGPRX2 was tested using enzyme-linked immunosorbent assay (ELISA), and levels of IL-4, IL-5, IL-6, IL-13, IL-23, and IL-33 were measured using Luminex multiplex assay in all subjects. Spearman correlation analysis was used to evaluate the correlations between biomarkers and other parameters in CSU patients, and logistic regression analysis was performed to identify factors influencing CSU. ResultsCSU patients exhibited significantly higher serum levels of MRGPRX2 (2.41[0, 11.51] ng/mL vs 0[0, 2.86] ng/mL, P＝0.015) and IL-23 (0.09[0.04, 0.56] pg/mL vs 0.05[0.03, 0.08] pg/mL, P＝0.033) than healthy controls. There was no difference in levels of other cytokines between the two groups. There was no difference in levels of MRGPRX2 and cytokines between severe and non-severe CSU patients. Correlation analysis showed that serum MRGPRX2 levels in CSU patients were positively correlated with IL-4 (r＝0.345, P＝0.010) and IL-6 (r＝0.395, P＝0.003) levels. Logistic regression analysis indicated that MRGPRX2≥0.055 ng/mL and IL-23≥0.135 pg/mL were independent risk factors for CSU (P＜0.05). ConclusionsSerum levels of MRGPRX2 and IL-23 in CSU patients are elevated, which may be involved in the pathogenesis of CSU. |
| format | Article |
| id | doaj-art-5959fb7868aa423b9e1e4d42740dea7b |
| institution | OA Journals |
| issn | 1008-6358 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Shanghai Chinese Clinical Medicine Press Co., Ltd. |
| record_format | Article |
| series | Zhongguo Linchuang Yixue |
| spelling | doaj-art-5959fb7868aa423b9e1e4d42740dea7b2025-08-20T01:57:32ZengShanghai Chinese Clinical Medicine Press Co., Ltd.Zhongguo Linchuang Yixue1008-63582024-12-0131687588210.12025/j.issn.1008-6358.2024.2024043320240433Correlations of Mas-related G protein-coupled receptor X2 and interleukin in patients with chronic spontaneous urticariaYiqi ZHU0Yixin SHAO1Duoqin WANG2Yanyun SHEN3Taiyu JIN4Lisi PENG5Hui TANG6Zijing XIAO7Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaObjectiveTo explore the correlations between serum Mas-related G protein-coupled receptor X2 (MRGPRX2), interleukin (IL)-4, IL-5, IL-6, IL-13, IL-23 and IL-33 levels and chronic spontaneous urticaria (CSU). MethodsThe clinical characteristics and laboratory data from 55 patients with CSU and 21 healthy controls at Huashan Hospital, Fudan University from February 2021 to September 2023 were collected. The disease activity and severity of CSU patients were assessed. Serum level of MRGPRX2 was tested using enzyme-linked immunosorbent assay (ELISA), and levels of IL-4, IL-5, IL-6, IL-13, IL-23, and IL-33 were measured using Luminex multiplex assay in all subjects. Spearman correlation analysis was used to evaluate the correlations between biomarkers and other parameters in CSU patients, and logistic regression analysis was performed to identify factors influencing CSU. ResultsCSU patients exhibited significantly higher serum levels of MRGPRX2 (2.41[0, 11.51] ng/mL vs 0[0, 2.86] ng/mL, P＝0.015) and IL-23 (0.09[0.04, 0.56] pg/mL vs 0.05[0.03, 0.08] pg/mL, P＝0.033) than healthy controls. There was no difference in levels of other cytokines between the two groups. There was no difference in levels of MRGPRX2 and cytokines between severe and non-severe CSU patients. Correlation analysis showed that serum MRGPRX2 levels in CSU patients were positively correlated with IL-4 (r＝0.345, P＝0.010) and IL-6 (r＝0.395, P＝0.003) levels. Logistic regression analysis indicated that MRGPRX2≥0.055 ng/mL and IL-23≥0.135 pg/mL were independent risk factors for CSU (P＜0.05). ConclusionsSerum levels of MRGPRX2 and IL-23 in CSU patients are elevated, which may be involved in the pathogenesis of CSU.https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2024.20240433chronic spontaneous urticariadisease severitymas-related g protein-coupled receptor x2interleukin-23 |
| spellingShingle | Yiqi ZHU Yixin SHAO Duoqin WANG Yanyun SHEN Taiyu JIN Lisi PENG Hui TANG Zijing XIAO Correlations of Mas-related G protein-coupled receptor X2 and interleukin in patients with chronic spontaneous urticaria Zhongguo Linchuang Yixue chronic spontaneous urticaria disease severity mas-related g protein-coupled receptor x2 interleukin-23 |
| title | Correlations of Mas-related G protein-coupled receptor X2 and interleukin in patients with chronic spontaneous urticaria |
| title_full | Correlations of Mas-related G protein-coupled receptor X2 and interleukin in patients with chronic spontaneous urticaria |
| title_fullStr | Correlations of Mas-related G protein-coupled receptor X2 and interleukin in patients with chronic spontaneous urticaria |
| title_full_unstemmed | Correlations of Mas-related G protein-coupled receptor X2 and interleukin in patients with chronic spontaneous urticaria |
| title_short | Correlations of Mas-related G protein-coupled receptor X2 and interleukin in patients with chronic spontaneous urticaria |
| title_sort | correlations of mas related g protein coupled receptor x2 and interleukin in patients with chronic spontaneous urticaria |
| topic | chronic spontaneous urticaria disease severity mas-related g protein-coupled receptor x2 interleukin-23 |
| url | https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2024.20240433 |
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