Circulating Monocytic Myeloid-Derived Suppressor Cells Are Elevated and Associated with Poor Prognosis in Acute Myeloid Leukemia
Background. Monocytic myeloid-derived suppressor cells (M-MDSCs) characterized with the phenotype of CD14+HLA-DRlow/- have attracted a lot of attention in the field of human tumor immunology. However, little is known about the roles of M-MDSCs in acute myeloid leukemia (AML) as opposed to their mult...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/7363084 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850224668245491712 |
|---|---|
| author | Huiping Wang Qianshan Tao Zhitao Wang Qing Zhang Hao Xiao Mei Zhou Yi Dong Zhimin Zhai |
| author_facet | Huiping Wang Qianshan Tao Zhitao Wang Qing Zhang Hao Xiao Mei Zhou Yi Dong Zhimin Zhai |
| author_sort | Huiping Wang |
| collection | DOAJ |
| description | Background. Monocytic myeloid-derived suppressor cells (M-MDSCs) characterized with the phenotype of CD14+HLA-DRlow/- have attracted a lot of attention in the field of human tumor immunology. However, little is known about the roles of M-MDSCs in acute myeloid leukemia (AML) as opposed to their multiple roles in solid tumors. Methods. We examined the frequencies of M-MDSCs identified for CD14+HLA-DRlow/- by flow cytometry in the peripheral circulating blood of 109 newly diagnosed adult patients with AML and 30 healthy controls (HC). Then, we, respectively, validated the clinic significance of circulating M-MDSCs on the relevance of spectral features for diagnostic stratification, induction therapy response, treatment effect maintenance, and long-term survival in AML. Results. Circulating M-MDSC frequencies of AML were significantly higher than those of HC both in CD14+ monocytes (46.22%±2.95% vs. 1.07%±0.17%, p<0.01) and peripheral blood mononuclear cells (PBMCs) (4.21%±0.80% vs. 0.17%±0.03%, p<0.01). Elevated circulating M-MDSCs in patients with AML were significantly associated with low complete remission (CR) rate, high relapse/refractory rate, and poor long-term survival, but had no correlation with common clinic risks and cytogenetic molecular risk categories. Conclusions. It was demonstrated that circulating M-MDSCs are elevated and associated with poor prognosis in AML, suggesting M-MDSCs might be a prognostic indicator for AML. |
| format | Article |
| id | doaj-art-594f6cfec8fb4d3997a9b43894f60281 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-594f6cfec8fb4d3997a9b43894f602812025-08-20T02:05:33ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/73630847363084Circulating Monocytic Myeloid-Derived Suppressor Cells Are Elevated and Associated with Poor Prognosis in Acute Myeloid LeukemiaHuiping Wang0Qianshan Tao1Zhitao Wang2Qing Zhang3Hao Xiao4Mei Zhou5Yi Dong6Zhimin Zhai7Department of Hematology, The Second Hospital of Anhui Medical University, and Hematology Research Center, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Hematology, The Second Hospital of Anhui Medical University, and Hematology Research Center, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Hematology, The Second Hospital of Anhui Medical University, and Hematology Research Center, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Hematology, The Second Hospital of Anhui Medical University, and Hematology Research Center, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Hematology, The Second Hospital of Anhui Medical University, and Hematology Research Center, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Hematology, The Second Hospital of Anhui Medical University, and Hematology Research Center, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Hematology, The Second Hospital of Anhui Medical University, and Hematology Research Center, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Hematology, The Second Hospital of Anhui Medical University, and Hematology Research Center, Anhui Medical University, Hefei, Anhui, ChinaBackground. Monocytic myeloid-derived suppressor cells (M-MDSCs) characterized with the phenotype of CD14+HLA-DRlow/- have attracted a lot of attention in the field of human tumor immunology. However, little is known about the roles of M-MDSCs in acute myeloid leukemia (AML) as opposed to their multiple roles in solid tumors. Methods. We examined the frequencies of M-MDSCs identified for CD14+HLA-DRlow/- by flow cytometry in the peripheral circulating blood of 109 newly diagnosed adult patients with AML and 30 healthy controls (HC). Then, we, respectively, validated the clinic significance of circulating M-MDSCs on the relevance of spectral features for diagnostic stratification, induction therapy response, treatment effect maintenance, and long-term survival in AML. Results. Circulating M-MDSC frequencies of AML were significantly higher than those of HC both in CD14+ monocytes (46.22%±2.95% vs. 1.07%±0.17%, p<0.01) and peripheral blood mononuclear cells (PBMCs) (4.21%±0.80% vs. 0.17%±0.03%, p<0.01). Elevated circulating M-MDSCs in patients with AML were significantly associated with low complete remission (CR) rate, high relapse/refractory rate, and poor long-term survival, but had no correlation with common clinic risks and cytogenetic molecular risk categories. Conclusions. It was demonstrated that circulating M-MDSCs are elevated and associated with poor prognosis in AML, suggesting M-MDSCs might be a prognostic indicator for AML.http://dx.doi.org/10.1155/2020/7363084 |
| spellingShingle | Huiping Wang Qianshan Tao Zhitao Wang Qing Zhang Hao Xiao Mei Zhou Yi Dong Zhimin Zhai Circulating Monocytic Myeloid-Derived Suppressor Cells Are Elevated and Associated with Poor Prognosis in Acute Myeloid Leukemia Journal of Immunology Research |
| title | Circulating Monocytic Myeloid-Derived Suppressor Cells Are Elevated and Associated with Poor Prognosis in Acute Myeloid Leukemia |
| title_full | Circulating Monocytic Myeloid-Derived Suppressor Cells Are Elevated and Associated with Poor Prognosis in Acute Myeloid Leukemia |
| title_fullStr | Circulating Monocytic Myeloid-Derived Suppressor Cells Are Elevated and Associated with Poor Prognosis in Acute Myeloid Leukemia |
| title_full_unstemmed | Circulating Monocytic Myeloid-Derived Suppressor Cells Are Elevated and Associated with Poor Prognosis in Acute Myeloid Leukemia |
| title_short | Circulating Monocytic Myeloid-Derived Suppressor Cells Are Elevated and Associated with Poor Prognosis in Acute Myeloid Leukemia |
| title_sort | circulating monocytic myeloid derived suppressor cells are elevated and associated with poor prognosis in acute myeloid leukemia |
| url | http://dx.doi.org/10.1155/2020/7363084 |
| work_keys_str_mv | AT huipingwang circulatingmonocyticmyeloidderivedsuppressorcellsareelevatedandassociatedwithpoorprognosisinacutemyeloidleukemia AT qianshantao circulatingmonocyticmyeloidderivedsuppressorcellsareelevatedandassociatedwithpoorprognosisinacutemyeloidleukemia AT zhitaowang circulatingmonocyticmyeloidderivedsuppressorcellsareelevatedandassociatedwithpoorprognosisinacutemyeloidleukemia AT qingzhang circulatingmonocyticmyeloidderivedsuppressorcellsareelevatedandassociatedwithpoorprognosisinacutemyeloidleukemia AT haoxiao circulatingmonocyticmyeloidderivedsuppressorcellsareelevatedandassociatedwithpoorprognosisinacutemyeloidleukemia AT meizhou circulatingmonocyticmyeloidderivedsuppressorcellsareelevatedandassociatedwithpoorprognosisinacutemyeloidleukemia AT yidong circulatingmonocyticmyeloidderivedsuppressorcellsareelevatedandassociatedwithpoorprognosisinacutemyeloidleukemia AT zhiminzhai circulatingmonocyticmyeloidderivedsuppressorcellsareelevatedandassociatedwithpoorprognosisinacutemyeloidleukemia |