The silence within: a conserved intragenic silencing element governs HTLV-1 expression via host RUNX1 complex binding

A defining feature of Human T-cell leukaemia virus type 1 (HTLV-1) infection is the establishment of reversible latency that can persist for many years. This latency enables the expansion of infected CD4+ T cells, ultimately contributing to adult T-cell leukaemia (ATL) and inflammatory disease. Suga...

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Bibliographic Details
Main Authors: Natasha Jansz, Damian F. J. Purcell
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Viruses
Online Access:https://doi.org/10.1038/s44298-025-00136-7
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