Anti-Ro/SSA antibodies in adult arrhythmias: pathogenesis, clinical implications, and therapeutic strategies
Anti-Ro/SSA antibodies, prevalent autoantibodies in connective tissue diseases, have well-established roles in fetal arrhythmias but their significance in adult arrhythmias remains underrecognized. Recent evidence highlights that anti-Ro/SSA antibodies may induce adult arrhythmias by disrupting card...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1561061/full |
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| author | Ruotong Cao Ruotong Cao Huasheng Lv Huasheng Lv Baopeng Tang Baopeng Tang Yanmei Lu Yanmei Lu |
| author_facet | Ruotong Cao Ruotong Cao Huasheng Lv Huasheng Lv Baopeng Tang Baopeng Tang Yanmei Lu Yanmei Lu |
| author_sort | Ruotong Cao |
| collection | DOAJ |
| description | Anti-Ro/SSA antibodies, prevalent autoantibodies in connective tissue diseases, have well-established roles in fetal arrhythmias but their significance in adult arrhythmias remains underrecognized. Recent evidence highlights that anti-Ro/SSA antibodies may induce adult arrhythmias by disrupting cardiac ion channel function, particularly through interactions with calcium and potassium channels, leading to electrophysiological disturbances including QT prolongation, atrioventricular block, and increased susceptibility to sudden cardiac death. Additionally, these antibodies can initiate inflammatory cascades, further contributing to myocardial fibrosis and conduction abnormalities. Despite the growing clinical relevance, detection of anti-Ro/SSA antibodies in unexplained arrhythmias is not routinely performed, limiting early recognition and intervention. Therapeutic strategies, currently based primarily on immunomodulatory therapies, show promise yet lack definitive evidence from randomized controlled trials. This review systematically summarizes recent advances regarding the pathogenic mechanisms, clinical implications, and therapeutic strategies for anti-Ro/SSA antibody-associated adult arrhythmias, aiming to enhance awareness, diagnostic precision, and management of this increasingly recognized clinical entity. |
| format | Article |
| id | doaj-art-594bb7e2442d4ef2bb0f9d8999532c0f |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-594bb7e2442d4ef2bb0f9d8999532c0f2025-08-20T01:48:36ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15610611561061Anti-Ro/SSA antibodies in adult arrhythmias: pathogenesis, clinical implications, and therapeutic strategiesRuotong Cao0Ruotong Cao1Huasheng Lv2Huasheng Lv3Baopeng Tang4Baopeng Tang5Yanmei Lu6Yanmei Lu7Department of Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaAnti-Ro/SSA antibodies, prevalent autoantibodies in connective tissue diseases, have well-established roles in fetal arrhythmias but their significance in adult arrhythmias remains underrecognized. Recent evidence highlights that anti-Ro/SSA antibodies may induce adult arrhythmias by disrupting cardiac ion channel function, particularly through interactions with calcium and potassium channels, leading to electrophysiological disturbances including QT prolongation, atrioventricular block, and increased susceptibility to sudden cardiac death. Additionally, these antibodies can initiate inflammatory cascades, further contributing to myocardial fibrosis and conduction abnormalities. Despite the growing clinical relevance, detection of anti-Ro/SSA antibodies in unexplained arrhythmias is not routinely performed, limiting early recognition and intervention. Therapeutic strategies, currently based primarily on immunomodulatory therapies, show promise yet lack definitive evidence from randomized controlled trials. This review systematically summarizes recent advances regarding the pathogenic mechanisms, clinical implications, and therapeutic strategies for anti-Ro/SSA antibody-associated adult arrhythmias, aiming to enhance awareness, diagnostic precision, and management of this increasingly recognized clinical entity.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1561061/fullanti-ro/ssa antibodiesarrhythmiaadultsautoimmunityimmunomodulatory therapy |
| spellingShingle | Ruotong Cao Ruotong Cao Huasheng Lv Huasheng Lv Baopeng Tang Baopeng Tang Yanmei Lu Yanmei Lu Anti-Ro/SSA antibodies in adult arrhythmias: pathogenesis, clinical implications, and therapeutic strategies Frontiers in Immunology anti-ro/ssa antibodies arrhythmia adults autoimmunity immunomodulatory therapy |
| title | Anti-Ro/SSA antibodies in adult arrhythmias: pathogenesis, clinical implications, and therapeutic strategies |
| title_full | Anti-Ro/SSA antibodies in adult arrhythmias: pathogenesis, clinical implications, and therapeutic strategies |
| title_fullStr | Anti-Ro/SSA antibodies in adult arrhythmias: pathogenesis, clinical implications, and therapeutic strategies |
| title_full_unstemmed | Anti-Ro/SSA antibodies in adult arrhythmias: pathogenesis, clinical implications, and therapeutic strategies |
| title_short | Anti-Ro/SSA antibodies in adult arrhythmias: pathogenesis, clinical implications, and therapeutic strategies |
| title_sort | anti ro ssa antibodies in adult arrhythmias pathogenesis clinical implications and therapeutic strategies |
| topic | anti-ro/ssa antibodies arrhythmia adults autoimmunity immunomodulatory therapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1561061/full |
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