Transmembrane TNF-TNFR2 signaling as a critical immunoregulatory node in pancreatic cancer

Transmembrane TNF-TNFR2 signaling as a critical immunoregulatory node in pancreatic cancer

Pancreatic cancer is characterized by extreme therapeutic resistance. In pancreatic cancers harboring high-risk genomes, we describe that cancer cell-neutrophil signaling circuitry provokes neutrophil-derived transmembrane (tm)TNF-TNFR2 interactions that dictate inflammatory polarization in cancer-a...

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Bibliographic Details
Main Authors: Erin M. Dickey, Anna Bianchi, Haleh Amirian, Peter J. Hosein, Denise Faustman, Roberta Brambilla, Jashodeep Datta
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
Chemotherapy
immunotherapy
myeloid-derived suppressor cells
neutrophils
pancreatic cancer
TNFR2
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2326694
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