Transmembrane TNF-TNFR2 signaling as a critical immunoregulatory node in pancreatic cancer
Pancreatic cancer is characterized by extreme therapeutic resistance. In pancreatic cancers harboring high-risk genomes, we describe that cancer cell-neutrophil signaling circuitry provokes neutrophil-derived transmembrane (tm)TNF-TNFR2 interactions that dictate inflammatory polarization in cancer-a...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | OncoImmunology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2024.2326694 |
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| _version_ | 1850060293343805440 |
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| author | Erin M. Dickey Anna Bianchi Haleh Amirian Peter J. Hosein Denise Faustman Roberta Brambilla Jashodeep Datta |
| author_facet | Erin M. Dickey Anna Bianchi Haleh Amirian Peter J. Hosein Denise Faustman Roberta Brambilla Jashodeep Datta |
| author_sort | Erin M. Dickey |
| collection | DOAJ |
| description | Pancreatic cancer is characterized by extreme therapeutic resistance. In pancreatic cancers harboring high-risk genomes, we describe that cancer cell-neutrophil signaling circuitry provokes neutrophil-derived transmembrane (tm)TNF-TNFR2 interactions that dictate inflammatory polarization in cancer-associated fibroblasts and T-cell dysfunction – two hallmarks of therapeutic resistance. Targeting tmTNF-TNFR2 signaling may sensitize pancreatic cancer to chemo±immunotherapy. |
| format | Article |
| id | doaj-art-594a145cfa4a4bf9ba5e867138b3d07d |
| institution | DOAJ |
| issn | 2162-402X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj-art-594a145cfa4a4bf9ba5e867138b3d07d2025-08-20T02:50:37ZengTaylor & Francis GroupOncoImmunology2162-402X2024-12-0113110.1080/2162402X.2024.2326694Transmembrane TNF-TNFR2 signaling as a critical immunoregulatory node in pancreatic cancerErin M. Dickey0Anna Bianchi1Haleh Amirian2Peter J. Hosein3Denise Faustman4Roberta Brambilla5Jashodeep Datta6Division of Surgical Oncology, DeWitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USADivision of Surgical Oncology, DeWitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USADivision of Surgical Oncology, DeWitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USADepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL, USADepartment of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAThe Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USADivision of Surgical Oncology, DeWitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USAPancreatic cancer is characterized by extreme therapeutic resistance. In pancreatic cancers harboring high-risk genomes, we describe that cancer cell-neutrophil signaling circuitry provokes neutrophil-derived transmembrane (tm)TNF-TNFR2 interactions that dictate inflammatory polarization in cancer-associated fibroblasts and T-cell dysfunction – two hallmarks of therapeutic resistance. Targeting tmTNF-TNFR2 signaling may sensitize pancreatic cancer to chemo±immunotherapy.https://www.tandfonline.com/doi/10.1080/2162402X.2024.2326694Chemotherapyimmunotherapymyeloid-derived suppressor cellsneutrophilspancreatic cancerTNFR2 |
| spellingShingle | Erin M. Dickey Anna Bianchi Haleh Amirian Peter J. Hosein Denise Faustman Roberta Brambilla Jashodeep Datta Transmembrane TNF-TNFR2 signaling as a critical immunoregulatory node in pancreatic cancer OncoImmunology Chemotherapy immunotherapy myeloid-derived suppressor cells neutrophils pancreatic cancer TNFR2 |
| title | Transmembrane TNF-TNFR2 signaling as a critical immunoregulatory node in pancreatic cancer |
| title_full | Transmembrane TNF-TNFR2 signaling as a critical immunoregulatory node in pancreatic cancer |
| title_fullStr | Transmembrane TNF-TNFR2 signaling as a critical immunoregulatory node in pancreatic cancer |
| title_full_unstemmed | Transmembrane TNF-TNFR2 signaling as a critical immunoregulatory node in pancreatic cancer |
| title_short | Transmembrane TNF-TNFR2 signaling as a critical immunoregulatory node in pancreatic cancer |
| title_sort | transmembrane tnf tnfr2 signaling as a critical immunoregulatory node in pancreatic cancer |
| topic | Chemotherapy immunotherapy myeloid-derived suppressor cells neutrophils pancreatic cancer TNFR2 |
| url | https://www.tandfonline.com/doi/10.1080/2162402X.2024.2326694 |
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