Improved insulin sensitivity and reproductive profile in overweight/obese PCOS patients undergoing integrative treatment with carnitines, L-arginine, L-cysteine and myo-inositol
Objective To evaluate the effects of a combination of carnitines, L-arginine, L-cysteine and myo-inositol on metabolic and reproductive parameters in PCOS overweight/obese patients.Methods This was a retrospective study analyzing information of a group of PCOS (n = 25) overweight/obesity patients, n...
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| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Gynecological Endocrinology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09513590.2025.2458710 |
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| author | Alessandro D. Genazzani Christian Battipaglia Martina Foschi Elisa Semprini Claudia Aio Eleonora Spelta Anna Kostrzak Maria Laura Rusce Anna Szeliga Blazej Meczekalski |
| author_facet | Alessandro D. Genazzani Christian Battipaglia Martina Foschi Elisa Semprini Claudia Aio Eleonora Spelta Anna Kostrzak Maria Laura Rusce Anna Szeliga Blazej Meczekalski |
| author_sort | Alessandro D. Genazzani |
| collection | DOAJ |
| description | Objective To evaluate the effects of a combination of carnitines, L-arginine, L-cysteine and myo-inositol on metabolic and reproductive parameters in PCOS overweight/obese patients.Methods This was a retrospective study analyzing information of a group of PCOS (n = 25) overweight/obesity patients, not requiring hormonal treatment, selected from the database of the ambulatory clinic of the Gynecological Endocrinology Center at the University of Modena and Reggio Emilia, Modena, Italy. The hormonal profile, routine exams and insulin and C-peptide response to oral glucose tolerance test (OGTT) were evaluated before and after 12 weeks of a daily oral complementary treatment with L-carnitine (500 mg), acetyl-L-carnitine (250 mg), L-arginine (500 mg), L-cysteine (100 mg) and myo-inositol (1 gr). The hepatic insulin extraction index was also calculated.Results The mix of complementary substances significantly improved metabolic parameters, homeostatic model assessment for insulin resistance index values and gonadotropin plasma levels. Glucose, C-peptide and insulin response to OGTT was significantly reduced as well as the hepatic insulin extraction index.Conclusion The administration of a combination of carnitines, L-arginine, L-cysteine and myoinositol improved gonadotropin plasma levels and insulin sensitivity in overweight/obese PCOS patients and restored hepatic clearance of insulin as demonstrated by the decreased hepatic insulin extraction index. |
| format | Article |
| id | doaj-art-5942a7af45344f16addfec99a2d950ff |
| institution | Kabale University |
| issn | 0951-3590 1473-0766 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gynecological Endocrinology |
| spelling | doaj-art-5942a7af45344f16addfec99a2d950ff2025-01-28T17:18:26ZengTaylor & Francis GroupGynecological Endocrinology0951-35901473-07662025-12-0141110.1080/09513590.2025.2458710Improved insulin sensitivity and reproductive profile in overweight/obese PCOS patients undergoing integrative treatment with carnitines, L-arginine, L-cysteine and myo-inositolAlessandro D. Genazzani0Christian Battipaglia1Martina Foschi2Elisa Semprini3Claudia Aio4Eleonora Spelta5Anna Kostrzak6Maria Laura Rusce7Anna Szeliga8Blazej Meczekalski9Gynecological Endocrinology Center, Department of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena, ItalyGynecological Endocrinology Center, Department of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena, ItalyGynecological Endocrinology Center, Department of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena, ItalyGynecological Endocrinology Center, Department of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena, ItalyGynecological Endocrinology Center, Department of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena, ItalyGynecological Endocrinology Center, Department of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena, ItalyDepartment of Gynecological Endocrinology, Poznan University of Medical Sciences, Poznan, PolandGynecological Endocrinology Center, Department of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena, ItalyDepartment of Gynecological Endocrinology, Poznan University of Medical Sciences, Poznan, PolandDepartment of Gynecological Endocrinology, Poznan University of Medical Sciences, Poznan, PolandObjective To evaluate the effects of a combination of carnitines, L-arginine, L-cysteine and myo-inositol on metabolic and reproductive parameters in PCOS overweight/obese patients.Methods This was a retrospective study analyzing information of a group of PCOS (n = 25) overweight/obesity patients, not requiring hormonal treatment, selected from the database of the ambulatory clinic of the Gynecological Endocrinology Center at the University of Modena and Reggio Emilia, Modena, Italy. The hormonal profile, routine exams and insulin and C-peptide response to oral glucose tolerance test (OGTT) were evaluated before and after 12 weeks of a daily oral complementary treatment with L-carnitine (500 mg), acetyl-L-carnitine (250 mg), L-arginine (500 mg), L-cysteine (100 mg) and myo-inositol (1 gr). The hepatic insulin extraction index was also calculated.Results The mix of complementary substances significantly improved metabolic parameters, homeostatic model assessment for insulin resistance index values and gonadotropin plasma levels. Glucose, C-peptide and insulin response to OGTT was significantly reduced as well as the hepatic insulin extraction index.Conclusion The administration of a combination of carnitines, L-arginine, L-cysteine and myoinositol improved gonadotropin plasma levels and insulin sensitivity in overweight/obese PCOS patients and restored hepatic clearance of insulin as demonstrated by the decreased hepatic insulin extraction index.https://www.tandfonline.com/doi/10.1080/09513590.2025.2458710Carnitinesinsulin resistancePCOSLHhepatic insulin extraction index |
| spellingShingle | Alessandro D. Genazzani Christian Battipaglia Martina Foschi Elisa Semprini Claudia Aio Eleonora Spelta Anna Kostrzak Maria Laura Rusce Anna Szeliga Blazej Meczekalski Improved insulin sensitivity and reproductive profile in overweight/obese PCOS patients undergoing integrative treatment with carnitines, L-arginine, L-cysteine and myo-inositol Gynecological Endocrinology Carnitines insulin resistance PCOS LH hepatic insulin extraction index |
| title | Improved insulin sensitivity and reproductive profile in overweight/obese PCOS patients undergoing integrative treatment with carnitines, L-arginine, L-cysteine and myo-inositol |
| title_full | Improved insulin sensitivity and reproductive profile in overweight/obese PCOS patients undergoing integrative treatment with carnitines, L-arginine, L-cysteine and myo-inositol |
| title_fullStr | Improved insulin sensitivity and reproductive profile in overweight/obese PCOS patients undergoing integrative treatment with carnitines, L-arginine, L-cysteine and myo-inositol |
| title_full_unstemmed | Improved insulin sensitivity and reproductive profile in overweight/obese PCOS patients undergoing integrative treatment with carnitines, L-arginine, L-cysteine and myo-inositol |
| title_short | Improved insulin sensitivity and reproductive profile in overweight/obese PCOS patients undergoing integrative treatment with carnitines, L-arginine, L-cysteine and myo-inositol |
| title_sort | improved insulin sensitivity and reproductive profile in overweight obese pcos patients undergoing integrative treatment with carnitines l arginine l cysteine and myo inositol |
| topic | Carnitines insulin resistance PCOS LH hepatic insulin extraction index |
| url | https://www.tandfonline.com/doi/10.1080/09513590.2025.2458710 |
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