Avenanthramide-C ameliorate doxorubicin-induced hepatotoxicity via modulating Akt/GSK-3β and Wnt-4/β-Catenin pathways in male rats

Avenanthramide-C ameliorate doxorubicin-induced hepatotoxicity via modulating Akt/GSK-3β and Wnt-4/β-Catenin pathways in male rats

BackgroundDoxorubicin (DOX) drugs used in cancer treatment can cause various adverse effects, including hepatotoxicity. Natural-derived constituents have shown promising effects in alleviating chemotherapy-induced toxicities. This study addressed the effect of Avenanthramides-C (AVN-C) treatment in...

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Bibliographic Details
Main Authors: Maha Abdullah Alwaili, Amal S. Abu-Almakarem, Salwa Aljohani, Sahar Abdulrahman Alkhodair, Maha M. Al-Bazi, Thamir M. Eid, Jehan Alamri, Maysa A. Mobasher, Norah K. Algarzae, Arwa Ishaq A. Khayyat, Luluah Saleh Alshaygy, Karim Samy El-Said
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
avenanthramides
antioxidants
anti-inflammatory
doxorubicin
hepatotoxicity
signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2024.1507786/full
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