Fetal Tachycardia Treated Successfully with Maternally Administered Propylthiouracil
Background. Fetal tachycardia may result from the transplacental passage of thyroid stimulating immunoglobulins in a patient with hypothyroidism secondary to ablation of Graves’ disease. Case. A 32-year-old woman, gravida 4, para 2, and abortus 1, with hypothyroidism and a history of Graves’ disease...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2014/968051 |
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| author | Barbara V. Parilla Farhan Hanif Keren Hasbani Thomas Iannucci |
| author_facet | Barbara V. Parilla Farhan Hanif Keren Hasbani Thomas Iannucci |
| author_sort | Barbara V. Parilla |
| collection | DOAJ |
| description | Background. Fetal tachycardia may result from the transplacental passage of thyroid stimulating immunoglobulins in a patient with hypothyroidism secondary to ablation of Graves’ disease. Case. A 32-year-old woman, gravida 4, para 2, and abortus 1, with hypothyroidism and a history of Graves’ disease, presented at 23 6/7 weeks of gestation with a persistent fetal tachycardia. The treatment of the fetal tachycardia with maternally administered digoxin and Sotalol was unsuccessful. Maternal thyroid stimulating immunoglobulins were elevated, and treatment with maternally administered propylthiouracil (PTU) resulted in a normal sinus rhythm for the remainder of the pregnancy. An induction of labor was performed at 37 weeks. Four to five days after delivery, the neonate exhibited clinical signs of hyperthyroidism necessitating treatment. Conclusion. Fetal tachycardia resulting from the transplacental passage of thyroid stimulating immunoglobulins can be successfully treated with maternally administered PTU. The neonate needs to be followed up closely as clinical signs of hyperthyroidism may occur as thyroid stimulating immunoglobulins continue to circulate in the neonate, while the serum levels of PTU decline. |
| format | Article |
| id | doaj-art-59322426ef9343b598b19e2a67680c89 |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-59322426ef9343b598b19e2a67680c892025-02-03T06:13:06ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922014-01-01201410.1155/2014/968051968051Fetal Tachycardia Treated Successfully with Maternally Administered PropylthiouracilBarbara V. Parilla0Farhan Hanif1Keren Hasbani2Thomas Iannucci3The Division of Maternal-Fetal Medicine, Advocate Lutheran General Hospital, Park Ridge, IL 60068, USAThe Division of Maternal-Fetal Medicine, Advocate Lutheran General Hospital, Park Ridge, IL 60068, USAThe Division of Pediatric Cardiology, Advocate Lutheran General Children’s Hospital, Park Ridge, IL 60068, USAThe Division of Maternal-Fetal Medicine, Advocate Lutheran General Hospital, Park Ridge, IL 60068, USABackground. Fetal tachycardia may result from the transplacental passage of thyroid stimulating immunoglobulins in a patient with hypothyroidism secondary to ablation of Graves’ disease. Case. A 32-year-old woman, gravida 4, para 2, and abortus 1, with hypothyroidism and a history of Graves’ disease, presented at 23 6/7 weeks of gestation with a persistent fetal tachycardia. The treatment of the fetal tachycardia with maternally administered digoxin and Sotalol was unsuccessful. Maternal thyroid stimulating immunoglobulins were elevated, and treatment with maternally administered propylthiouracil (PTU) resulted in a normal sinus rhythm for the remainder of the pregnancy. An induction of labor was performed at 37 weeks. Four to five days after delivery, the neonate exhibited clinical signs of hyperthyroidism necessitating treatment. Conclusion. Fetal tachycardia resulting from the transplacental passage of thyroid stimulating immunoglobulins can be successfully treated with maternally administered PTU. The neonate needs to be followed up closely as clinical signs of hyperthyroidism may occur as thyroid stimulating immunoglobulins continue to circulate in the neonate, while the serum levels of PTU decline.http://dx.doi.org/10.1155/2014/968051 |
| spellingShingle | Barbara V. Parilla Farhan Hanif Keren Hasbani Thomas Iannucci Fetal Tachycardia Treated Successfully with Maternally Administered Propylthiouracil Case Reports in Obstetrics and Gynecology |
| title | Fetal Tachycardia Treated Successfully with Maternally Administered Propylthiouracil |
| title_full | Fetal Tachycardia Treated Successfully with Maternally Administered Propylthiouracil |
| title_fullStr | Fetal Tachycardia Treated Successfully with Maternally Administered Propylthiouracil |
| title_full_unstemmed | Fetal Tachycardia Treated Successfully with Maternally Administered Propylthiouracil |
| title_short | Fetal Tachycardia Treated Successfully with Maternally Administered Propylthiouracil |
| title_sort | fetal tachycardia treated successfully with maternally administered propylthiouracil |
| url | http://dx.doi.org/10.1155/2014/968051 |
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