Tirzepatide in Sport: A Comprehensive Review of its Metabolic Impacts and Potential Applications for Athletes
Introduction Tirzepatide, a dual agonist of glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, has emerged as a transformative metabolic therapy with exceptional efficacy in weight management and glycemic control. Its relevance in sports science is growing...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-01-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57025 |
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| author | Wiktor Biesiada Ewelina Kopczyńska Piotr Kulej Justyna Woźniak Justyna Weronika Kmieć Anna-Mariia Chernysh Aleksandra Dusińska Jakub Waszczyński Kamila Fuczyło Karolina Stankevič |
| author_facet | Wiktor Biesiada Ewelina Kopczyńska Piotr Kulej Justyna Woźniak Justyna Weronika Kmieć Anna-Mariia Chernysh Aleksandra Dusińska Jakub Waszczyński Kamila Fuczyło Karolina Stankevič |
| author_sort | Wiktor Biesiada |
| collection | DOAJ |
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Introduction
Tirzepatide, a dual agonist of glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, has emerged as a transformative metabolic therapy with exceptional efficacy in weight management and glycemic control. Its relevance in sports science is growing, with potential benefits in weight optimization, energy balance, and recovery. By influencing glucose homeostasis, fat oxidation, and systemic inflammation, tirzepatide may enhance athletic performance. This review examines its pharmacological effects, impact on body composition, and implications for endurance, strength, and recovery in athletes, while addressing ethical and regulatory considerations, including anti-doping concerns.
Purpose of the Work: To analyze tirzepatide’s pharmacological actions, clinical effects, and potential applications in optimizing sports performance, recovery, and body composition.
Materials and Methods: A comprehensive review of scientific literature was conducted across databases including PubMed, Scopus, Web of Science, Embase, and Google Scholar. Search terms encompassed tirzepatide, GLP-1/GIP dual agonist, metabolic therapy, sports performance, body composition, endurance, and athlete recovery. Relevant studies were synthesized to compile findings.
Results: Tirzepatide provides significant metabolic benefits, such as enhanced fat oxidation, improved glucose regulation, and reduced systemic inflammation. Its effects on body composition include substantial fat mass reduction, particularly visceral adiposity, while preserving lean muscle mass. These attributes suggest its potential to enhance endurance via glycogen-sparing mechanisms and improve recovery after exercise. However, concerns about misuse in competitive sports underline the need for regulatory oversight. Further research is necessary to evaluate tirzepatide’s long-term effects on athletic performance and address associated ethical challenges.
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| format | Article |
| id | doaj-art-5931654cae134b30ae991fa8f4a3c90e |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-5931654cae134b30ae991fa8f4a3c90e2025-01-21T08:23:01ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-01-013710.12775/QS.2025.37.57025Tirzepatide in Sport: A Comprehensive Review of its Metabolic Impacts and Potential Applications for AthletesWiktor Biesiada0https://orcid.org/0009-0002-2662-5300Ewelina Kopczyńska1https://orcid.org/0009-0006-5665-6043Piotr Kulej2https://orcid.org/0009-0004-6655-6877Justyna Woźniak3https://orcid.org/0009-0009-7785-4665Justyna Weronika Kmieć4https://orcid.org/0009-0001-0570-9575Anna-Mariia Chernysh5https://orcid.org/0009-0008-6900-1593Aleksandra Dusińska6https://orcid.org/0000-0001-5197-9683Jakub Waszczyński7https://orcid.org/0009-0003-4156-2253Kamila Fuczyło8https://orcid.org/0000-0002-3443-8663Karolina Stankevič9https://orcid.org/0009-0008-3572-1066Gromkowski Regional Specialist Hospital, Koszarowa 5, 51-149 WrocławGromkowski Regional Specialist Hospital, Koszarowa 5, 51-149 WrocławRegional Specialist Hospital in Wrocław Research and Development Center, H. M. Kamieńskiego 73a, 51-124 Wrocław Independent Public Healthcare Institution of the Ministry of Interior and Administration, Kronikarza Galla 25, 30-053 KrakówGromkowski Regional Specialist Hospital, Koszarowa 5, 51-149 WrocławRegional Specialist Hospital in Wrocław Research and Development Center, H. M. Kamieńskiego 73a, 51-124 WrocławUniwersity Clinical Hospital in Wrocław, Borowska 213, 50-556 WrocławPCK Marine Hospital in Gdynia, Powstania Styczniowego 1, 81-519 GdyniaLower-Silesian Center of Oncology, Pulmonary and Hematology in Wrocław, pl. Hirszfelda 12, 53-413 WrocławLower-Silesian Center of Oncology, Pulmonary and Hematology in Wrocław, pl. Hirszfelda 12, 53-413 Wrocław Introduction Tirzepatide, a dual agonist of glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, has emerged as a transformative metabolic therapy with exceptional efficacy in weight management and glycemic control. Its relevance in sports science is growing, with potential benefits in weight optimization, energy balance, and recovery. By influencing glucose homeostasis, fat oxidation, and systemic inflammation, tirzepatide may enhance athletic performance. This review examines its pharmacological effects, impact on body composition, and implications for endurance, strength, and recovery in athletes, while addressing ethical and regulatory considerations, including anti-doping concerns. Purpose of the Work: To analyze tirzepatide’s pharmacological actions, clinical effects, and potential applications in optimizing sports performance, recovery, and body composition. Materials and Methods: A comprehensive review of scientific literature was conducted across databases including PubMed, Scopus, Web of Science, Embase, and Google Scholar. Search terms encompassed tirzepatide, GLP-1/GIP dual agonist, metabolic therapy, sports performance, body composition, endurance, and athlete recovery. Relevant studies were synthesized to compile findings. Results: Tirzepatide provides significant metabolic benefits, such as enhanced fat oxidation, improved glucose regulation, and reduced systemic inflammation. Its effects on body composition include substantial fat mass reduction, particularly visceral adiposity, while preserving lean muscle mass. These attributes suggest its potential to enhance endurance via glycogen-sparing mechanisms and improve recovery after exercise. However, concerns about misuse in competitive sports underline the need for regulatory oversight. Further research is necessary to evaluate tirzepatide’s long-term effects on athletic performance and address associated ethical challenges. https://apcz.umk.pl/QS/article/view/57025TirzepatideGIP/GLP-1 dual agonistmetabolic therapysports performancebody compositionanti-doping |
| spellingShingle | Wiktor Biesiada Ewelina Kopczyńska Piotr Kulej Justyna Woźniak Justyna Weronika Kmieć Anna-Mariia Chernysh Aleksandra Dusińska Jakub Waszczyński Kamila Fuczyło Karolina Stankevič Tirzepatide in Sport: A Comprehensive Review of its Metabolic Impacts and Potential Applications for Athletes Quality in Sport Tirzepatide GIP/GLP-1 dual agonist metabolic therapy sports performance body composition anti-doping |
| title | Tirzepatide in Sport: A Comprehensive Review of its Metabolic Impacts and Potential Applications for Athletes |
| title_full | Tirzepatide in Sport: A Comprehensive Review of its Metabolic Impacts and Potential Applications for Athletes |
| title_fullStr | Tirzepatide in Sport: A Comprehensive Review of its Metabolic Impacts and Potential Applications for Athletes |
| title_full_unstemmed | Tirzepatide in Sport: A Comprehensive Review of its Metabolic Impacts and Potential Applications for Athletes |
| title_short | Tirzepatide in Sport: A Comprehensive Review of its Metabolic Impacts and Potential Applications for Athletes |
| title_sort | tirzepatide in sport a comprehensive review of its metabolic impacts and potential applications for athletes |
| topic | Tirzepatide GIP/GLP-1 dual agonist metabolic therapy sports performance body composition anti-doping |
| url | https://apcz.umk.pl/QS/article/view/57025 |
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