Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease
We studied the number and function of angiogenic progenitor cells and growth factors in children aged 5–18 years without acute illness, 43 with Hemoglobin SS and 68 with normal hemoglobin. Hemoglobin SS subjects had at least twice as many mononuclear cell colonies and more circulating progenitor ce...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Anemia |
| Online Access: | http://dx.doi.org/10.1155/2012/156598 |
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| author | Solomon F. Ofori-Acquah Iris D. Buchanan Ifeyinwa Osunkwo Jerry Manlove-Simmons Feyisayo Lawal Alexander Quarshie Arshed A. Quyyumi Gary H. Gibbons Beatrice E. Gee |
| author_facet | Solomon F. Ofori-Acquah Iris D. Buchanan Ifeyinwa Osunkwo Jerry Manlove-Simmons Feyisayo Lawal Alexander Quarshie Arshed A. Quyyumi Gary H. Gibbons Beatrice E. Gee |
| author_sort | Solomon F. Ofori-Acquah |
| collection | DOAJ |
| description | We studied the number and function of angiogenic progenitor cells and growth factors in children aged 5–18 years without acute illness, 43 with Hemoglobin SS and 68 with normal hemoglobin. Hemoglobin SS subjects had at least twice as many mononuclear cell colonies and more circulating progenitor cell than Control subjects. Plasma concentrations of erythropoietin, angiopoietin-2, and stromal-derived growth factor (SDF)-1α were significantly higher in children with Hemoglobin SS compared to Control subjects. In a multivariate analysis model, SDF-1α concentration was found to be associated with both CPC number and total white blood cell count in the Hemoglobin SS group, suggesting that SDF-1α produced by ischemic tissues plays a role in mobilizing these cells in children with Hemoglobin SS. Despite having a higher number of angiogenic progenitor cells, children with Hemoglobin SS had slower migration of cultured mononuclear cells. |
| format | Article |
| id | doaj-art-592bf53b9b7e43279d38cec6aa106e19 |
| institution | Kabale University |
| issn | 2090-1267 2090-1275 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anemia |
| spelling | doaj-art-592bf53b9b7e43279d38cec6aa106e192025-02-03T01:30:13ZengWileyAnemia2090-12672090-12752012-01-01201210.1155/2012/156598156598Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell DiseaseSolomon F. Ofori-Acquah0Iris D. Buchanan1Ifeyinwa Osunkwo2Jerry Manlove-Simmons3Feyisayo Lawal4Alexander Quarshie5Arshed A. Quyyumi6Gary H. Gibbons7Beatrice E. Gee8Department of Pediatrics, Division of Hematology/Oncology, Emory University School of Medicine, 2015 Uppergate Dr. NE, Atlanta, GA 30322, USADepartment of Pediatrics, Morehouse School of Medicine, 720 Westview Drive, SW Atlanta, GA 30310-1495, USADepartment of Pediatrics, Division of Hematology/Oncology, Emory University School of Medicine, 2015 Uppergate Dr. NE, Atlanta, GA 30322, USACardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Drive, SW Atlanta, GA 30310-1495, USAMorehouse College, 830 Westview Dr SW, Atlanta, GA 30314, USABiostatistics Core, Morehouse School of Medicine, 720 Westview Drive, SW Atlanta, GA 30310-1495, USADepartment of Medicine, Division of Cardiology, 1462 Clifton Road N.E. Suite 507, Atlanta, GA 30322, USACardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Drive, SW Atlanta, GA 30310-1495, USADepartment of Pediatrics, Morehouse School of Medicine, 720 Westview Drive, SW Atlanta, GA 30310-1495, USAWe studied the number and function of angiogenic progenitor cells and growth factors in children aged 5–18 years without acute illness, 43 with Hemoglobin SS and 68 with normal hemoglobin. Hemoglobin SS subjects had at least twice as many mononuclear cell colonies and more circulating progenitor cell than Control subjects. Plasma concentrations of erythropoietin, angiopoietin-2, and stromal-derived growth factor (SDF)-1α were significantly higher in children with Hemoglobin SS compared to Control subjects. In a multivariate analysis model, SDF-1α concentration was found to be associated with both CPC number and total white blood cell count in the Hemoglobin SS group, suggesting that SDF-1α produced by ischemic tissues plays a role in mobilizing these cells in children with Hemoglobin SS. Despite having a higher number of angiogenic progenitor cells, children with Hemoglobin SS had slower migration of cultured mononuclear cells.http://dx.doi.org/10.1155/2012/156598 |
| spellingShingle | Solomon F. Ofori-Acquah Iris D. Buchanan Ifeyinwa Osunkwo Jerry Manlove-Simmons Feyisayo Lawal Alexander Quarshie Arshed A. Quyyumi Gary H. Gibbons Beatrice E. Gee Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease Anemia |
| title | Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease |
| title_full | Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease |
| title_fullStr | Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease |
| title_full_unstemmed | Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease |
| title_short | Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease |
| title_sort | elevated circulating angiogenic progenitors and white blood cells are associated with hypoxia inducible angiogenic growth factors in children with sickle cell disease |
| url | http://dx.doi.org/10.1155/2012/156598 |
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