The Role of Hyaluronan in Innate Defense Responses of the Intestine
Hyaluronan is an abundant extracellular matrix component prevalent in the vertebrate intestinal tract. Here we discuss what is known about hyaluronan distribution during homeostasis and inflammatory diseases of the gut and discuss ways in which this glycosaminoglycan can participate in regulating in...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2015/481301 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553744864116736 |
|---|---|
| author | Carol A. de la Motte Sean P. Kessler |
| author_facet | Carol A. de la Motte Sean P. Kessler |
| author_sort | Carol A. de la Motte |
| collection | DOAJ |
| description | Hyaluronan is an abundant extracellular matrix component prevalent in the vertebrate intestinal tract. Here we discuss what is known about hyaluronan distribution during homeostasis and inflammatory diseases of the gut and discuss ways in which this glycosaminoglycan can participate in regulating innate host defense mechanisms. These natural responses include mechanisms promoting rapid leukocyte recruitment after bacterial challenge/colon tissue damage as well as promoting epithelial defense mechanisms in the intestine. |
| format | Article |
| id | doaj-art-5924746485534d959b4ba6d1222a50ba |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-5924746485534d959b4ba6d1222a50ba2025-02-03T05:53:21ZengWileyInternational Journal of Cell Biology1687-88761687-88842015-01-01201510.1155/2015/481301481301The Role of Hyaluronan in Innate Defense Responses of the IntestineCarol A. de la Motte0Sean P. Kessler1Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USADepartment of Pathobiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USAHyaluronan is an abundant extracellular matrix component prevalent in the vertebrate intestinal tract. Here we discuss what is known about hyaluronan distribution during homeostasis and inflammatory diseases of the gut and discuss ways in which this glycosaminoglycan can participate in regulating innate host defense mechanisms. These natural responses include mechanisms promoting rapid leukocyte recruitment after bacterial challenge/colon tissue damage as well as promoting epithelial defense mechanisms in the intestine.http://dx.doi.org/10.1155/2015/481301 |
| spellingShingle | Carol A. de la Motte Sean P. Kessler The Role of Hyaluronan in Innate Defense Responses of the Intestine International Journal of Cell Biology |
| title | The Role of Hyaluronan in Innate Defense Responses of the Intestine |
| title_full | The Role of Hyaluronan in Innate Defense Responses of the Intestine |
| title_fullStr | The Role of Hyaluronan in Innate Defense Responses of the Intestine |
| title_full_unstemmed | The Role of Hyaluronan in Innate Defense Responses of the Intestine |
| title_short | The Role of Hyaluronan in Innate Defense Responses of the Intestine |
| title_sort | role of hyaluronan in innate defense responses of the intestine |
| url | http://dx.doi.org/10.1155/2015/481301 |
| work_keys_str_mv | AT caroladelamotte theroleofhyaluronanininnatedefenseresponsesoftheintestine AT seanpkessler theroleofhyaluronanininnatedefenseresponsesoftheintestine AT caroladelamotte roleofhyaluronanininnatedefenseresponsesoftheintestine AT seanpkessler roleofhyaluronanininnatedefenseresponsesoftheintestine |