The Potential Role of Th9 Cell Related Cytokine and Transcription Factors in Patients with Hepatic Alveolar Echinococcosis
Human alveolar echinococcosis (AE) is a lethal parasitic infectious disease which may lead to liver failure if left untreated. It is caused by the larval stage of the fox tapeworm Echinococcus multilocularis and usually develops a substantial infiltrative occupation in solid organs. During the infec...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/895416 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849410765334773760 |
|---|---|
| author | Tuerhongjiang Tuxun Shadike Apaer Hai-Zhang Ma Heng Zhang Amina Aierken Ren-Yong Lin Hao Wen |
| author_facet | Tuerhongjiang Tuxun Shadike Apaer Hai-Zhang Ma Heng Zhang Amina Aierken Ren-Yong Lin Hao Wen |
| author_sort | Tuerhongjiang Tuxun |
| collection | DOAJ |
| description | Human alveolar echinococcosis (AE) is a lethal parasitic infectious disease which may lead to liver failure if left untreated. It is caused by the larval stage of the fox tapeworm Echinococcus multilocularis and usually develops a substantial infiltrative occupation in solid organs. During the infection, T helper subsets are known to play crucial role in crosstalk between the parasite and human host. Th9 cells, a new member of CD4+ T cell family which is characterized by its specific cytokine IL-9 and transcription factors PU.1 and IRF-4, have been known recently to have a critical role in allergic diseases, and cancers as well as the parasitic infection. To assess the potential role of Th9 cells during the infection, the mRNA levels of IL-9, PU.1, and IRF-4 both in peripheral blood mononuclear cells and in liver tissues were, respectively, detected by using real-time PCR. The plasma concentration levels of IL-9 were detected by using enzyme linked immunosorbent assay (ELISA). Th9 related cytokine IL-9 and transcription factors PU.1 and IRF-4 mRNA levels elevated both in PBMCs, and in hepatic lesion and paralesion tissues in AE patients. This may facilitate the infiltrative growth of the parasite and its persistence in human host. |
| format | Article |
| id | doaj-art-592409b8bc664e31b80dd7ed463e7d79 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-592409b8bc664e31b80dd7ed463e7d792025-08-20T03:34:58ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/895416895416The Potential Role of Th9 Cell Related Cytokine and Transcription Factors in Patients with Hepatic Alveolar EchinococcosisTuerhongjiang Tuxun0Shadike Apaer1Hai-Zhang Ma2Heng Zhang3Amina Aierken4Ren-Yong Lin5Hao Wen6Department of Liver & Laparoscopic Surgery, Digestive and Vascular Surgery Centre, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region 830054, ChinaDepartment of Liver & Laparoscopic Surgery, Digestive and Vascular Surgery Centre, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region 830054, ChinaDepartment of Liver & Laparoscopic Surgery, Digestive and Vascular Surgery Centre, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region 830054, ChinaDepartment of Liver & Laparoscopic Surgery, Digestive and Vascular Surgery Centre, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region 830054, ChinaDepartment of Ultrasonography, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region 830054, ChinaState Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region 830054, ChinaDepartment of Liver & Laparoscopic Surgery, Digestive and Vascular Surgery Centre, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region 830054, ChinaHuman alveolar echinococcosis (AE) is a lethal parasitic infectious disease which may lead to liver failure if left untreated. It is caused by the larval stage of the fox tapeworm Echinococcus multilocularis and usually develops a substantial infiltrative occupation in solid organs. During the infection, T helper subsets are known to play crucial role in crosstalk between the parasite and human host. Th9 cells, a new member of CD4+ T cell family which is characterized by its specific cytokine IL-9 and transcription factors PU.1 and IRF-4, have been known recently to have a critical role in allergic diseases, and cancers as well as the parasitic infection. To assess the potential role of Th9 cells during the infection, the mRNA levels of IL-9, PU.1, and IRF-4 both in peripheral blood mononuclear cells and in liver tissues were, respectively, detected by using real-time PCR. The plasma concentration levels of IL-9 were detected by using enzyme linked immunosorbent assay (ELISA). Th9 related cytokine IL-9 and transcription factors PU.1 and IRF-4 mRNA levels elevated both in PBMCs, and in hepatic lesion and paralesion tissues in AE patients. This may facilitate the infiltrative growth of the parasite and its persistence in human host.http://dx.doi.org/10.1155/2015/895416 |
| spellingShingle | Tuerhongjiang Tuxun Shadike Apaer Hai-Zhang Ma Heng Zhang Amina Aierken Ren-Yong Lin Hao Wen The Potential Role of Th9 Cell Related Cytokine and Transcription Factors in Patients with Hepatic Alveolar Echinococcosis Journal of Immunology Research |
| title | The Potential Role of Th9 Cell Related Cytokine and Transcription Factors in Patients with Hepatic Alveolar Echinococcosis |
| title_full | The Potential Role of Th9 Cell Related Cytokine and Transcription Factors in Patients with Hepatic Alveolar Echinococcosis |
| title_fullStr | The Potential Role of Th9 Cell Related Cytokine and Transcription Factors in Patients with Hepatic Alveolar Echinococcosis |
| title_full_unstemmed | The Potential Role of Th9 Cell Related Cytokine and Transcription Factors in Patients with Hepatic Alveolar Echinococcosis |
| title_short | The Potential Role of Th9 Cell Related Cytokine and Transcription Factors in Patients with Hepatic Alveolar Echinococcosis |
| title_sort | potential role of th9 cell related cytokine and transcription factors in patients with hepatic alveolar echinococcosis |
| url | http://dx.doi.org/10.1155/2015/895416 |
| work_keys_str_mv | AT tuerhongjiangtuxun thepotentialroleofth9cellrelatedcytokineandtranscriptionfactorsinpatientswithhepaticalveolarechinococcosis AT shadikeapaer thepotentialroleofth9cellrelatedcytokineandtranscriptionfactorsinpatientswithhepaticalveolarechinococcosis AT haizhangma thepotentialroleofth9cellrelatedcytokineandtranscriptionfactorsinpatientswithhepaticalveolarechinococcosis AT hengzhang thepotentialroleofth9cellrelatedcytokineandtranscriptionfactorsinpatientswithhepaticalveolarechinococcosis AT aminaaierken thepotentialroleofth9cellrelatedcytokineandtranscriptionfactorsinpatientswithhepaticalveolarechinococcosis AT renyonglin thepotentialroleofth9cellrelatedcytokineandtranscriptionfactorsinpatientswithhepaticalveolarechinococcosis AT haowen thepotentialroleofth9cellrelatedcytokineandtranscriptionfactorsinpatientswithhepaticalveolarechinococcosis AT tuerhongjiangtuxun potentialroleofth9cellrelatedcytokineandtranscriptionfactorsinpatientswithhepaticalveolarechinococcosis AT shadikeapaer potentialroleofth9cellrelatedcytokineandtranscriptionfactorsinpatientswithhepaticalveolarechinococcosis AT haizhangma potentialroleofth9cellrelatedcytokineandtranscriptionfactorsinpatientswithhepaticalveolarechinococcosis AT hengzhang potentialroleofth9cellrelatedcytokineandtranscriptionfactorsinpatientswithhepaticalveolarechinococcosis AT aminaaierken potentialroleofth9cellrelatedcytokineandtranscriptionfactorsinpatientswithhepaticalveolarechinococcosis AT renyonglin potentialroleofth9cellrelatedcytokineandtranscriptionfactorsinpatientswithhepaticalveolarechinococcosis AT haowen potentialroleofth9cellrelatedcytokineandtranscriptionfactorsinpatientswithhepaticalveolarechinococcosis |