Monkeypox virus and type 1 diabetes: a molecular insight into inflammatory signaling and β-cell autoimmunity

Monkeypox virus and type 1 diabetes: a molecular insight into inflammatory signaling and β-cell autoimmunity

Abstract The current worldwide pandemic of monkeypox (MPXV) elicited apprehensions over its possible long-term health ramifications. Recent data indicate a potential association between MPXV infection and the onset of autoimmune disorders, such as type 1 diabetes (T1D). This article analyzes the pos...

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Main Authors: Yahya A. Almutawif, Haydar M. Al-kuraishy, Ali I. Al-Gareeb, Ali K. Albuhadily, Hamza M. A. Eid, Athanasios Alexiou, Marios Papadakis, Mohammed E. Abo‑El Fetoh, Gaber El-Saber Batiha
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Virology Journal
Subjects:
Monkeypox
Type 1 diabetes
Autoimmunity
Immune dysregulation
Viral infections
Pancreatic β-cells
Online Access:https://doi.org/10.1186/s12985-025-02822-7
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Summary:Abstract The current worldwide pandemic of monkeypox (MPXV) elicited apprehensions over its possible long-term health ramifications. Recent data indicate a potential association between MPXV infection and the onset of autoimmune disorders, such as type 1 diabetes (T1D). This article analyzes the possible methods for MPXV infection to induce autoimmune responses and damage pancreatic β-cells. We examine from published articles the possible MPXV-induced immune dysregulation and inflammation in the development of T1D. Utilizing insights from other diabetogenic viruses, such as enterovirus and SARS-CoV-2. Currently, the association between MPXV and the development of T1D is scarce. Therefore, additional studies are essential for establishing a conclusive causal link between MPXV and T1D. Graphical abstract
ISSN:1743-422X

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