A Rare Neurological Complication of Ranolazine

Myoclonus is not a known side effect of ranolazine. We report a case of myoclonus in a 72-year-old female who underwent cardiac catheterization for angina and was started on ranolazine after the procedure. Two days after ranolazine therapy on 1000 mg per day in divided doses, myoclonus developed, wh...

Full description

Saved in:
Bibliographic Details
Main Authors: Jahan Porhomayon, Gino Zadeii, Alireza Yarahmadi
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Case Reports in Neurological Medicine
Online Access:http://dx.doi.org/10.1155/2013/451206
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1850225502210490368
author Jahan Porhomayon
Gino Zadeii
Alireza Yarahmadi
author_facet Jahan Porhomayon
Gino Zadeii
Alireza Yarahmadi
author_sort Jahan Porhomayon
collection DOAJ
description Myoclonus is not a known side effect of ranolazine. We report a case of myoclonus in a 72-year-old female who underwent cardiac catheterization for angina and was started on ranolazine after the procedure. Two days after ranolazine therapy on 1000 mg per day in divided doses, myoclonus developed, which severely impaired her normal activity. Her symptoms resolved 2 days after discontinuation of ranolazine. Ranolazine was resumed after discharge from hospital with recurrent myoclonus after two days of therapy. The causal relationship between ranolazine and myoclonus was suggested by cessation of myoclonus after ranolazine was discontinued.
format Article
id doaj-art-591cb70f26c44b59b92d12b2a3768e2a
institution OA Journals
issn 2090-6668
2090-6676
language English
publishDate 2013-01-01
publisher Wiley
record_format Article
series Case Reports in Neurological Medicine
spelling doaj-art-591cb70f26c44b59b92d12b2a3768e2a2025-08-20T02:05:20ZengWileyCase Reports in Neurological Medicine2090-66682090-66762013-01-01201310.1155/2013/451206451206A Rare Neurological Complication of RanolazineJahan Porhomayon0Gino Zadeii1Alireza Yarahmadi2VA Western New York Healthcare System, Division of Critical Care and Pain Medicine, Department of Anesthesiology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14215, USAUniversity of Iowa, Mason City Cardiology, Mason City, IA 50401, USADirector of Mercy North-Iowa Neurology and Sleep Laboratory, University of Iowa, Mason City Neurology, Mason City, IA 50401, USAMyoclonus is not a known side effect of ranolazine. We report a case of myoclonus in a 72-year-old female who underwent cardiac catheterization for angina and was started on ranolazine after the procedure. Two days after ranolazine therapy on 1000 mg per day in divided doses, myoclonus developed, which severely impaired her normal activity. Her symptoms resolved 2 days after discontinuation of ranolazine. Ranolazine was resumed after discharge from hospital with recurrent myoclonus after two days of therapy. The causal relationship between ranolazine and myoclonus was suggested by cessation of myoclonus after ranolazine was discontinued.http://dx.doi.org/10.1155/2013/451206
spellingShingle Jahan Porhomayon
Gino Zadeii
Alireza Yarahmadi
A Rare Neurological Complication of Ranolazine
Case Reports in Neurological Medicine
title A Rare Neurological Complication of Ranolazine
title_full A Rare Neurological Complication of Ranolazine
title_fullStr A Rare Neurological Complication of Ranolazine
title_full_unstemmed A Rare Neurological Complication of Ranolazine
title_short A Rare Neurological Complication of Ranolazine
title_sort rare neurological complication of ranolazine
url http://dx.doi.org/10.1155/2013/451206
work_keys_str_mv AT jahanporhomayon arareneurologicalcomplicationofranolazine
AT ginozadeii arareneurologicalcomplicationofranolazine
AT alirezayarahmadi arareneurologicalcomplicationofranolazine
AT jahanporhomayon rareneurologicalcomplicationofranolazine
AT ginozadeii rareneurologicalcomplicationofranolazine
AT alirezayarahmadi rareneurologicalcomplicationofranolazine