Potential Use of Stem Cells for Kidney Regeneration
Significant advances have been made in stem cell research over the past decade. A number of nonhematopoietic sources of stem cells (or progenitor cells) have been identified, including endothelial stem cells and neural stem cells. These discoveries have been a major step toward the use of stem cells...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.4061/2011/591731 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850225501673619456 |
|---|---|
| author | Takashi Yokoo Kei Matsumoto Shinya Yokote |
| author_facet | Takashi Yokoo Kei Matsumoto Shinya Yokote |
| author_sort | Takashi Yokoo |
| collection | DOAJ |
| description | Significant advances have been made in stem cell research over the past decade. A number of nonhematopoietic sources of stem cells (or progenitor cells) have been identified, including endothelial stem cells and neural stem cells. These discoveries have been a major step toward the use of stem cells for potential clinical applications of organ regeneration. Accordingly, kidney regeneration is currently gaining considerable attention to replace kidney dialysis as the ultimate therapeutic strategy for renal failure. However, due to anatomic complications, the kidney is believed to be the hardest organ to regenerate; it is virtually impossible to imagine such a complicated organ being completely rebuilt from pluripotent stem cells by gene or chemical manipulation. Nevertheless, several groups are taking on this big challenge.
In this manuscript, current advances in renal stem cell research are reviewed and their usefulness for kidney regeneration discussed. We also reviewed the current knowledge of the emerging field of renal stem cell biology. |
| format | Article |
| id | doaj-art-591a969540bc42c78eae376189de09e7 |
| institution | OA Journals |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-591a969540bc42c78eae376189de09e72025-08-20T02:05:20ZengWileyInternational Journal of Nephrology2090-214X2090-21582011-01-01201110.4061/2011/591731591731Potential Use of Stem Cells for Kidney RegenerationTakashi Yokoo0Kei Matsumoto1Shinya Yokote2Project Laboratory for Kidney Regeneration, Institute of DNA Medicine, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, 105-8461, JapanProject Laboratory for Kidney Regeneration, Institute of DNA Medicine, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, 105-8461, JapanProject Laboratory for Kidney Regeneration, Institute of DNA Medicine, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, 105-8461, JapanSignificant advances have been made in stem cell research over the past decade. A number of nonhematopoietic sources of stem cells (or progenitor cells) have been identified, including endothelial stem cells and neural stem cells. These discoveries have been a major step toward the use of stem cells for potential clinical applications of organ regeneration. Accordingly, kidney regeneration is currently gaining considerable attention to replace kidney dialysis as the ultimate therapeutic strategy for renal failure. However, due to anatomic complications, the kidney is believed to be the hardest organ to regenerate; it is virtually impossible to imagine such a complicated organ being completely rebuilt from pluripotent stem cells by gene or chemical manipulation. Nevertheless, several groups are taking on this big challenge. In this manuscript, current advances in renal stem cell research are reviewed and their usefulness for kidney regeneration discussed. We also reviewed the current knowledge of the emerging field of renal stem cell biology.http://dx.doi.org/10.4061/2011/591731 |
| spellingShingle | Takashi Yokoo Kei Matsumoto Shinya Yokote Potential Use of Stem Cells for Kidney Regeneration International Journal of Nephrology |
| title | Potential Use of Stem Cells for Kidney Regeneration |
| title_full | Potential Use of Stem Cells for Kidney Regeneration |
| title_fullStr | Potential Use of Stem Cells for Kidney Regeneration |
| title_full_unstemmed | Potential Use of Stem Cells for Kidney Regeneration |
| title_short | Potential Use of Stem Cells for Kidney Regeneration |
| title_sort | potential use of stem cells for kidney regeneration |
| url | http://dx.doi.org/10.4061/2011/591731 |
| work_keys_str_mv | AT takashiyokoo potentialuseofstemcellsforkidneyregeneration AT keimatsumoto potentialuseofstemcellsforkidneyregeneration AT shinyayokote potentialuseofstemcellsforkidneyregeneration |