Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines
Abstract We included measurement of pre-existing immunity to human endemic coronaviruses (HCoV) in a Phase I/II study of SARS-CoV-2 spike protein vaccine candidates. A Binding Antibody Multiplex Assay measured HCoV-specific IgG to the receptor binding domain or full-length spike of human coronavirus...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-025-01203-z |
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| author | Guy de Bruyn Haritha Adhikarla Caroline K. Brackett Yichen Jia Premkumar Lakshmanane Sarah V. Mudrak Sheetal Sawant Donghui Zhang Roman M. Chicz Saranya Sridhar Georgia D. Tomaras Kelly E. Seaton |
| author_facet | Guy de Bruyn Haritha Adhikarla Caroline K. Brackett Yichen Jia Premkumar Lakshmanane Sarah V. Mudrak Sheetal Sawant Donghui Zhang Roman M. Chicz Saranya Sridhar Georgia D. Tomaras Kelly E. Seaton |
| author_sort | Guy de Bruyn |
| collection | DOAJ |
| description | Abstract We included measurement of pre-existing immunity to human endemic coronaviruses (HCoV) in a Phase I/II study of SARS-CoV-2 spike protein vaccine candidates. A Binding Antibody Multiplex Assay measured HCoV-specific IgG to the receptor binding domain or full-length spike of human coronaviruses HKU1, 229E, NL63, and OC43. We found no evidence for the impact of HCoV antibodies on neutralizing and binding antibody responses to the candidate SARS-CoV-2 vaccines. |
| format | Article |
| id | doaj-art-59198b3d1e6f45a1aa22c2d986e58491 |
| institution | Kabale University |
| issn | 2059-0105 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj-art-59198b3d1e6f45a1aa22c2d986e584912025-08-20T04:01:46ZengNature Portfolionpj Vaccines2059-01052025-07-011011610.1038/s41541-025-01203-zPrior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccinesGuy de Bruyn0Haritha Adhikarla1Caroline K. Brackett2Yichen Jia3Premkumar Lakshmanane4Sarah V. Mudrak5Sheetal Sawant6Donghui Zhang7Roman M. Chicz8Saranya Sridhar9Georgia D. Tomaras10Kelly E. Seaton11Sanofi Vaccines Research & DevelopmentSanofi Vaccines Research & DevelopmentDepartment of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke UniversitySanofi Vaccines Research & DevelopmentDepartment of Microbiology and Immunology, University of North CarolinaDepartment of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke UniversityDepartment of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke UniversitySanofi Vaccines R&DSanofi Vaccines R&DSanofi Vaccines R&DDepartment of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke UniversityDepartment of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke UniversityAbstract We included measurement of pre-existing immunity to human endemic coronaviruses (HCoV) in a Phase I/II study of SARS-CoV-2 spike protein vaccine candidates. A Binding Antibody Multiplex Assay measured HCoV-specific IgG to the receptor binding domain or full-length spike of human coronaviruses HKU1, 229E, NL63, and OC43. We found no evidence for the impact of HCoV antibodies on neutralizing and binding antibody responses to the candidate SARS-CoV-2 vaccines.https://doi.org/10.1038/s41541-025-01203-z |
| spellingShingle | Guy de Bruyn Haritha Adhikarla Caroline K. Brackett Yichen Jia Premkumar Lakshmanane Sarah V. Mudrak Sheetal Sawant Donghui Zhang Roman M. Chicz Saranya Sridhar Georgia D. Tomaras Kelly E. Seaton Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines npj Vaccines |
| title | Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines |
| title_full | Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines |
| title_fullStr | Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines |
| title_full_unstemmed | Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines |
| title_short | Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines |
| title_sort | prior human endemic coronavirus exposure does not affect humoral responses to sars cov 2 protein vaccines |
| url | https://doi.org/10.1038/s41541-025-01203-z |
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