Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines

Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines

Abstract We included measurement of pre-existing immunity to human endemic coronaviruses (HCoV) in a Phase I/II study of SARS-CoV-2 spike protein vaccine candidates. A Binding Antibody Multiplex Assay measured HCoV-specific IgG to the receptor binding domain or full-length spike of human coronavirus...

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Main Authors: Guy de Bruyn, Haritha Adhikarla, Caroline K. Brackett, Yichen Jia, Premkumar Lakshmanane, Sarah V. Mudrak, Sheetal Sawant, Donghui Zhang, Roman M. Chicz, Saranya Sridhar, Georgia D. Tomaras, Kelly E. Seaton
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01203-z
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Summary:Abstract We included measurement of pre-existing immunity to human endemic coronaviruses (HCoV) in a Phase I/II study of SARS-CoV-2 spike protein vaccine candidates. A Binding Antibody Multiplex Assay measured HCoV-specific IgG to the receptor binding domain or full-length spike of human coronaviruses HKU1, 229E, NL63, and OC43. We found no evidence for the impact of HCoV antibodies on neutralizing and binding antibody responses to the candidate SARS-CoV-2 vaccines.
ISSN:2059-0105

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