Interaction between mitochondrial oxidative stress and myocardial fibrosis in the context of diabetes
Diabetes represents a global chronic health issue and has emerged as a crucial risk factor for cardiovascular diseases (CVD). Myocardial fibrosis (MF), which often accompanies diabetes, plays a pivotal role in the progression of cardiac dysfunction and heart failure (HF). Recent research has highlig...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1596436/full |
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| author | Pu-Hua Zhang Nuo-Nan Li Nuo-Nan Li Xiang Gu Chun-Xia Zhou Zhen-Zhen Jiang Xian-Jun Luo Xian-Jun Luo Hong-Wen Zhu Xiao-Yong Zhu |
| author_facet | Pu-Hua Zhang Nuo-Nan Li Nuo-Nan Li Xiang Gu Chun-Xia Zhou Zhen-Zhen Jiang Xian-Jun Luo Xian-Jun Luo Hong-Wen Zhu Xiao-Yong Zhu |
| author_sort | Pu-Hua Zhang |
| collection | DOAJ |
| description | Diabetes represents a global chronic health issue and has emerged as a crucial risk factor for cardiovascular diseases (CVD). Myocardial fibrosis (MF), which often accompanies diabetes, plays a pivotal role in the progression of cardiac dysfunction and heart failure (HF). Recent research has highlighted mitochondrial oxidative stress (OS) as a fundamental mechanism driving MF in diabetic conditions. Elevated blood glucose levels and metabolic imbalances lead to mitochondrial impairments, which in turn cause an excessive buildup of reactive oxygen species (ROS), culminating in OS. This OS not only inflicts direct damage on myocardial cells but also facilitates the proliferation of myocardial fibroblasts and collagen accumulation through the activation of specific signaling pathways, thus intensifying MF. Furthermore, MF itself intensifies mitochondrial OS, creating a vicious cycle that ultimately impairs myocardial structure and function. Thus, a thorough understanding of the interaction between mitochondrial OS and MF in diabetes is crucial for identifying effective therapeutic targets and enhancing the early diagnosis and intervention strategies for diabetic cardiomyopathy. |
| format | Article |
| id | doaj-art-5910d79a803c45da8983eb0c5e72e622 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-5910d79a803c45da8983eb0c5e72e6222025-08-20T03:24:52ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-06-011610.3389/fendo.2025.15964361596436Interaction between mitochondrial oxidative stress and myocardial fibrosis in the context of diabetesPu-Hua Zhang0Nuo-Nan Li1Nuo-Nan Li2Xiang Gu3Chun-Xia Zhou4Zhen-Zhen Jiang5Xian-Jun Luo6Xian-Jun Luo7Hong-Wen Zhu8Xiao-Yong Zhu9Department of Cardiology, Jiujiang University Affiliated Hospital, Jiujiang, Jiangxi, ChinaSchool of Clinical Medicine, Gannan Medical University, Ganzhou, Jiangxi, ChinaJiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, ChinaDepartment of Cardiology, Jiujiang University Affiliated Hospital, Jiujiang, Jiangxi, ChinaJiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, ChinaDepartment of Cardiology, Jiujiang University Affiliated Hospital, Jiujiang, Jiangxi, ChinaSchool of Clinical Medicine, Gannan Medical University, Ganzhou, Jiangxi, ChinaJiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, ChinaDepartment of Cardiology, Jiujiang University Affiliated Hospital, Jiujiang, Jiangxi, ChinaDepartment of Cardiology, Jiujiang University Affiliated Hospital, Jiujiang, Jiangxi, ChinaDiabetes represents a global chronic health issue and has emerged as a crucial risk factor for cardiovascular diseases (CVD). Myocardial fibrosis (MF), which often accompanies diabetes, plays a pivotal role in the progression of cardiac dysfunction and heart failure (HF). Recent research has highlighted mitochondrial oxidative stress (OS) as a fundamental mechanism driving MF in diabetic conditions. Elevated blood glucose levels and metabolic imbalances lead to mitochondrial impairments, which in turn cause an excessive buildup of reactive oxygen species (ROS), culminating in OS. This OS not only inflicts direct damage on myocardial cells but also facilitates the proliferation of myocardial fibroblasts and collagen accumulation through the activation of specific signaling pathways, thus intensifying MF. Furthermore, MF itself intensifies mitochondrial OS, creating a vicious cycle that ultimately impairs myocardial structure and function. Thus, a thorough understanding of the interaction between mitochondrial OS and MF in diabetes is crucial for identifying effective therapeutic targets and enhancing the early diagnosis and intervention strategies for diabetic cardiomyopathy.https://www.frontiersin.org/articles/10.3389/fendo.2025.1596436/fulldiabetesmitochondrial oxidative stressmyocardial fibrosissignaling pathwaysinteractiondrug therapy |
| spellingShingle | Pu-Hua Zhang Nuo-Nan Li Nuo-Nan Li Xiang Gu Chun-Xia Zhou Zhen-Zhen Jiang Xian-Jun Luo Xian-Jun Luo Hong-Wen Zhu Xiao-Yong Zhu Interaction between mitochondrial oxidative stress and myocardial fibrosis in the context of diabetes Frontiers in Endocrinology diabetes mitochondrial oxidative stress myocardial fibrosis signaling pathways interaction drug therapy |
| title | Interaction between mitochondrial oxidative stress and myocardial fibrosis in the context of diabetes |
| title_full | Interaction between mitochondrial oxidative stress and myocardial fibrosis in the context of diabetes |
| title_fullStr | Interaction between mitochondrial oxidative stress and myocardial fibrosis in the context of diabetes |
| title_full_unstemmed | Interaction between mitochondrial oxidative stress and myocardial fibrosis in the context of diabetes |
| title_short | Interaction between mitochondrial oxidative stress and myocardial fibrosis in the context of diabetes |
| title_sort | interaction between mitochondrial oxidative stress and myocardial fibrosis in the context of diabetes |
| topic | diabetes mitochondrial oxidative stress myocardial fibrosis signaling pathways interaction drug therapy |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1596436/full |
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