Evaluation of autonomic nervous system functions in frame of heart rate variability in children with inflammatory bowel disease in remission
Heart Rate Variability (HRV) is one of the reliable and noninvasive parameters to evaluate autonomic control of the cardiovascular system in patients. The aim of our study was to assess autonomic function in pediatric patients with inflammatory bowel disease (IBD) in remission using Power Spectral...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2018-08-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/875 |
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| author | Helen Aghdasi-Bornaun Günsel Kutluk Gonca Keskindemirci Kazım Öztarhan Reyhan Dedeoğlu Nuh Yılmaz Öykü Tosun |
| author_facet | Helen Aghdasi-Bornaun Günsel Kutluk Gonca Keskindemirci Kazım Öztarhan Reyhan Dedeoğlu Nuh Yılmaz Öykü Tosun |
| author_sort | Helen Aghdasi-Bornaun |
| collection | DOAJ |
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Heart Rate Variability (HRV) is one of the reliable and noninvasive parameters to evaluate autonomic control of the cardiovascular system in patients. The aim of our study was to assess autonomic function in pediatric patients with inflammatory bowel disease (IBD) in remission using Power Spectral Analysis of HRV. Autonomic cardiovascular function was evaluated by time and frequency-domain indexes of spontaneous heart rate in 36 IBD children patients in remission phase and 36 sex and age matched healthy controls. Twenty children with Ulcerative Colitis (UC) and 16 patients with Crohn`s disease (CD) were diagnosed according to their history, physical and laboratory examination, endoscopic, histopathological and radiological findings of upper and lower gastrointestinal system. Significant decrease was observed at HRV parameters in IBD patients when compared with control group. These differences was found in some of time domain parameters (NNmean, SDNNtotal, SDNNday) and frequency domain parameters (TP, LF,VLF) (p < 0.05). Also, there was a significant higher minimum heart rate ratio (p < 0.04) in patients in comparison to the control group. In the IBD group, there was a relative tendency for parasympathetic suppression and sympathetic predominance which reflects an autonomic dysfunction. This imbalance has a circadian rhythm and it is more obvious during the day. These observations may suggest a previously unrecognized role of chronic inflammation for autonomic modulation in IBD.
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| format | Article |
| id | doaj-art-590b93fdb65b44c3bd45caac7816c6c9 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2018-08-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-590b93fdb65b44c3bd45caac7816c6c92025-08-20T03:01:10ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212018-08-0160410.24953/turkjped.2018.04.008Evaluation of autonomic nervous system functions in frame of heart rate variability in children with inflammatory bowel disease in remissionHelen Aghdasi-Bornaun0Günsel Kutluk1Gonca Keskindemirci2Kazım Öztarhan3Reyhan Dedeoğlu4Nuh Yılmaz5Öykü Tosun6Departments of Pediatric Cardiology, University of Health Sciences Kanuni Sultan Süleyman Education and Research Hospital, Istanbul, Turkey.Departments of Pediatric Gastroenterology Hepatology and Nutrition University of Health Sciences Kanuni Sultan Süleyman Education and Research Hospital, Istanbul, Turkey.Departments of Pediatrics, University of Health Sciences Kanuni Sultan Süleyman Education and Research Hospital, Istanbul, Turkey.Departments of Pediatric Cardiology, University of Health Sciences Kanuni Sultan Süleyman Education and Research Hospital, Istanbul, Turkey.Department of Pediatric Cardiology, Istanbul University Cerrahpaşa Medical Faculty, Istanbul, Turkey.Department of Pediatric Cardiology, İstinye University Medical Faculty, Istanbul, Turkey.Department of Pediatric Cardiology, Medeniyet University Medical Faculty, Istanbul, Turkey. Heart Rate Variability (HRV) is one of the reliable and noninvasive parameters to evaluate autonomic control of the cardiovascular system in patients. The aim of our study was to assess autonomic function in pediatric patients with inflammatory bowel disease (IBD) in remission using Power Spectral Analysis of HRV. Autonomic cardiovascular function was evaluated by time and frequency-domain indexes of spontaneous heart rate in 36 IBD children patients in remission phase and 36 sex and age matched healthy controls. Twenty children with Ulcerative Colitis (UC) and 16 patients with Crohn`s disease (CD) were diagnosed according to their history, physical and laboratory examination, endoscopic, histopathological and radiological findings of upper and lower gastrointestinal system. Significant decrease was observed at HRV parameters in IBD patients when compared with control group. These differences was found in some of time domain parameters (NNmean, SDNNtotal, SDNNday) and frequency domain parameters (TP, LF,VLF) (p < 0.05). Also, there was a significant higher minimum heart rate ratio (p < 0.04) in patients in comparison to the control group. In the IBD group, there was a relative tendency for parasympathetic suppression and sympathetic predominance which reflects an autonomic dysfunction. This imbalance has a circadian rhythm and it is more obvious during the day. These observations may suggest a previously unrecognized role of chronic inflammation for autonomic modulation in IBD. https://turkjpediatr.org/article/view/875heart rate variabilityinflammatory bowel diseasepediatrics |
| spellingShingle | Helen Aghdasi-Bornaun Günsel Kutluk Gonca Keskindemirci Kazım Öztarhan Reyhan Dedeoğlu Nuh Yılmaz Öykü Tosun Evaluation of autonomic nervous system functions in frame of heart rate variability in children with inflammatory bowel disease in remission The Turkish Journal of Pediatrics heart rate variability inflammatory bowel disease pediatrics |
| title | Evaluation of autonomic nervous system functions in frame of heart rate variability in children with inflammatory bowel disease in remission |
| title_full | Evaluation of autonomic nervous system functions in frame of heart rate variability in children with inflammatory bowel disease in remission |
| title_fullStr | Evaluation of autonomic nervous system functions in frame of heart rate variability in children with inflammatory bowel disease in remission |
| title_full_unstemmed | Evaluation of autonomic nervous system functions in frame of heart rate variability in children with inflammatory bowel disease in remission |
| title_short | Evaluation of autonomic nervous system functions in frame of heart rate variability in children with inflammatory bowel disease in remission |
| title_sort | evaluation of autonomic nervous system functions in frame of heart rate variability in children with inflammatory bowel disease in remission |
| topic | heart rate variability inflammatory bowel disease pediatrics |
| url | https://turkjpediatr.org/article/view/875 |
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