Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation.

Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation.

Serotonin is a ubiquitous chemical transmitter with particularly important roles in the gastrointestinal, cardiovascular and central nervous systems. Modulation of serotonergic signaling occurs, in part, by uptake of the transmitter by the serotonin transporter (SERT). In the brain, SERT is the targ...

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Bibliographic Details
Main Authors: Evan M Green, Jonathan A Coleman, Eric Gouaux
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0145688&type=printable
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