The potential effects of nanoparticles in gene regulation and expression in mammalian, bacterial and plant cells – A comprehensive review
Gene regulation and expression are fundamental, though challenging life processes involved in the development and rectification of various cellular mechanisms. Nanoparticles have been employed as gene regulatory systems that can efficiently modulate gene expression owing to their unique physiochemic...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Plant Nano Biology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773111125000129 |
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| author | Ayesha Javaid Neelma Munir Zainul Abideen Bernardo Duarte Zamin Shaheed Siddiqui Rukhama Haq Shagufta Naz |
| author_facet | Ayesha Javaid Neelma Munir Zainul Abideen Bernardo Duarte Zamin Shaheed Siddiqui Rukhama Haq Shagufta Naz |
| author_sort | Ayesha Javaid |
| collection | DOAJ |
| description | Gene regulation and expression are fundamental, though challenging life processes involved in the development and rectification of various cellular mechanisms. Nanoparticles have been employed as gene regulatory systems that can efficiently modulate gene expression owing to their unique physiochemical properties. Exposure to metal, metal oxide, carbon and polymer-based nanomaterials can lead to arbitrary DNA methylation and thus damage targeted cells by generating oxidative stress genes in mammals and bacteria. However, the valuable role of carbon-based nanoparticles in the suppression of tumor growth factor genes or genes attributed to inhibition of angiogenesis is an innovative approach in medical science, which may stop the progression of abnormal cells. Predominantly, nanoparticles induced the genes involved in oxidative stress, DNA methylation, pro-inflammatory reactions, signaling pathways, cell proliferation and differentiation. The expression of toxin-antitoxin genes in bacteria is also controlled by nanoparticles, such as ZnO, which inhibits biofilm formation in bacteria and is responsible for antibiotic resistance. Exposure of plants to several types of nanoparticles upregulated the genes involved in shielding the plants against oxidative and abiotic stresses, predominantly salinity stress. Gene modulation by nanoparticles in different organisms or species is not uniform. This article describes gene regulation and expression studies performed in nanoparticle-exposed mammalian, bacterial, and plant cells. This review will help researchers to upgrade gene regulation approaches, complementing the potential of nanomaterials in regulating cell activities, thereby embarking on their use in therapeutics for many genetic diseases. |
| format | Article |
| id | doaj-art-590864869f7c42908fed2adfaabece1d |
| institution | DOAJ |
| issn | 2773-1111 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Plant Nano Biology |
| spelling | doaj-art-590864869f7c42908fed2adfaabece1d2025-08-20T02:50:30ZengElsevierPlant Nano Biology2773-11112025-02-011110014510.1016/j.plana.2025.100145The potential effects of nanoparticles in gene regulation and expression in mammalian, bacterial and plant cells – A comprehensive reviewAyesha Javaid0Neelma Munir1Zainul Abideen2Bernardo Duarte3Zamin Shaheed Siddiqui4Rukhama Haq5Shagufta Naz6Department of Biotechnology, Lahore College for Women University, Lahore, PakistanDepartment of Biotechnology, Lahore College for Women University, Lahore, Pakistan; Corresponding author.Dr. Muhammad Ajmal Khan Institute of Sustainable Halophyte Utilization, University of Karachi, 75270, Pakistan; College of Agriculture, University of Al Dhaid, P.O. Box 27272, Sharjah 21325, United Arab Emirates; Corresponding author at: Dr. Muhammad Ajmal Khan Institute of Sustainable Halophyte Utilization, University of Karachi, 75270, Pakistan.MARE—Marine and Environmental Sciences Centre & ARNET – Aquatic Research Network Associated Laboratory, Faculdade de Ciências da Universidade de Lisboa, Lisbon, Campo Grande 1749-016, Brazil; Departamento de Biologia Vegetal, Faculdade de Ciências da Universidade de Lisboa, Lisboa, Campo Grande 1749-016, PortugalDepartment of Botany, University of Karachi, Karachi 75270, PakistanDepartment of Biotechnology, Lahore College for Women University, Lahore, PakistanDepartment of Biotechnology, Lahore College for Women University, Lahore, PakistanGene regulation and expression are fundamental, though challenging life processes involved in the development and rectification of various cellular mechanisms. Nanoparticles have been employed as gene regulatory systems that can efficiently modulate gene expression owing to their unique physiochemical properties. Exposure to metal, metal oxide, carbon and polymer-based nanomaterials can lead to arbitrary DNA methylation and thus damage targeted cells by generating oxidative stress genes in mammals and bacteria. However, the valuable role of carbon-based nanoparticles in the suppression of tumor growth factor genes or genes attributed to inhibition of angiogenesis is an innovative approach in medical science, which may stop the progression of abnormal cells. Predominantly, nanoparticles induced the genes involved in oxidative stress, DNA methylation, pro-inflammatory reactions, signaling pathways, cell proliferation and differentiation. The expression of toxin-antitoxin genes in bacteria is also controlled by nanoparticles, such as ZnO, which inhibits biofilm formation in bacteria and is responsible for antibiotic resistance. Exposure of plants to several types of nanoparticles upregulated the genes involved in shielding the plants against oxidative and abiotic stresses, predominantly salinity stress. Gene modulation by nanoparticles in different organisms or species is not uniform. This article describes gene regulation and expression studies performed in nanoparticle-exposed mammalian, bacterial, and plant cells. This review will help researchers to upgrade gene regulation approaches, complementing the potential of nanomaterials in regulating cell activities, thereby embarking on their use in therapeutics for many genetic diseases.http://www.sciencedirect.com/science/article/pii/S2773111125000129Oxidative stressCell proliferationTranscriptionTranslationNanomaterialsBiofilm |
| spellingShingle | Ayesha Javaid Neelma Munir Zainul Abideen Bernardo Duarte Zamin Shaheed Siddiqui Rukhama Haq Shagufta Naz The potential effects of nanoparticles in gene regulation and expression in mammalian, bacterial and plant cells – A comprehensive review Plant Nano Biology Oxidative stress Cell proliferation Transcription Translation Nanomaterials Biofilm |
| title | The potential effects of nanoparticles in gene regulation and expression in mammalian, bacterial and plant cells – A comprehensive review |
| title_full | The potential effects of nanoparticles in gene regulation and expression in mammalian, bacterial and plant cells – A comprehensive review |
| title_fullStr | The potential effects of nanoparticles in gene regulation and expression in mammalian, bacterial and plant cells – A comprehensive review |
| title_full_unstemmed | The potential effects of nanoparticles in gene regulation and expression in mammalian, bacterial and plant cells – A comprehensive review |
| title_short | The potential effects of nanoparticles in gene regulation and expression in mammalian, bacterial and plant cells – A comprehensive review |
| title_sort | potential effects of nanoparticles in gene regulation and expression in mammalian bacterial and plant cells a comprehensive review |
| topic | Oxidative stress Cell proliferation Transcription Translation Nanomaterials Biofilm |
| url | http://www.sciencedirect.com/science/article/pii/S2773111125000129 |
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