Potential Effects of Dietary Isoflavones on Drug-Induced Liver Injury
Numerous prescribed drugs and herbal and dietary supplements have been reported to cause drug-induced acute liver injury, which is a frequent cause of acute liver failure (ALF). It is a tremendous challenge with ever-increasing drug application in the medication system for huge populations. Drug-ind...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Food Quality |
| Online Access: | http://dx.doi.org/10.1155/2021/2870969 |
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| author | Liangliang Yao Muhammad Farrukh Nisar Tingdong Yan Chunpeng (Craig) Wan |
| author_facet | Liangliang Yao Muhammad Farrukh Nisar Tingdong Yan Chunpeng (Craig) Wan |
| author_sort | Liangliang Yao |
| collection | DOAJ |
| description | Numerous prescribed drugs and herbal and dietary supplements have been reported to cause drug-induced acute liver injury, which is a frequent cause of acute liver failure (ALF). It is a tremendous challenge with ever-increasing drug application in the medication system for huge populations. Drug-induced acute liver injury can lead to diverse pathologies similar to acute and chronic hepatitis, acute liver failure, biliary obstruction, fatty liver disease, and so on. Recently, extensive work demonstrated that isoflavones play an essential and protecting role in drug-induced liver injury (DILI). The isoflavones mediated hepatoprotection by modulating specific genes linked with control of cellular redox homeostasis and inflammatory responses. Isoflavones upregulate oxidative stress-responsive nuclear factor erythroid 2-like 2 (Nrf2), downregulate inflammatory nuclear factor-κB (NF-κB) signaling pathways, and modulate a balance between cell survival and death. Moreover, isoflavones actively inhibit the expression of cytochromes P450 (CYPs) enzyme during drug metabolism. Moreover, isoflavones are also linked with farnesoid X receptor (FXR) activation and signal transducer and activator of transcription factor 3 (STAT3) phosphorylation in hepatoprotection DILI. In vivo and in vitro studies clearly stated that isoflavones bear strong antioxidant potential and promising agents for hepatotoxicity prevention and stressed their potential role as therapeutic supplements in DILI. The current review will elaborate on isoflavones’ preventive and therapeutic potential concisely and highlight various molecular targets to exert a protective effect on DILI. |
| format | Article |
| id | doaj-art-590809209133432fb90b690a79b8bfb0 |
| institution | OA Journals |
| issn | 0146-9428 1745-4557 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Food Quality |
| spelling | doaj-art-590809209133432fb90b690a79b8bfb02025-08-20T02:05:20ZengWileyJournal of Food Quality0146-94281745-45572021-01-01202110.1155/2021/28709692870969Potential Effects of Dietary Isoflavones on Drug-Induced Liver InjuryLiangliang Yao0Muhammad Farrukh Nisar1Tingdong Yan2Chunpeng (Craig) Wan3Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330006, ChinaJiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruits & Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang 330045, ChinaSchool of Pharmacy, Nantong University, Nantong 226019, ChinaJiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruits & Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang 330045, ChinaNumerous prescribed drugs and herbal and dietary supplements have been reported to cause drug-induced acute liver injury, which is a frequent cause of acute liver failure (ALF). It is a tremendous challenge with ever-increasing drug application in the medication system for huge populations. Drug-induced acute liver injury can lead to diverse pathologies similar to acute and chronic hepatitis, acute liver failure, biliary obstruction, fatty liver disease, and so on. Recently, extensive work demonstrated that isoflavones play an essential and protecting role in drug-induced liver injury (DILI). The isoflavones mediated hepatoprotection by modulating specific genes linked with control of cellular redox homeostasis and inflammatory responses. Isoflavones upregulate oxidative stress-responsive nuclear factor erythroid 2-like 2 (Nrf2), downregulate inflammatory nuclear factor-κB (NF-κB) signaling pathways, and modulate a balance between cell survival and death. Moreover, isoflavones actively inhibit the expression of cytochromes P450 (CYPs) enzyme during drug metabolism. Moreover, isoflavones are also linked with farnesoid X receptor (FXR) activation and signal transducer and activator of transcription factor 3 (STAT3) phosphorylation in hepatoprotection DILI. In vivo and in vitro studies clearly stated that isoflavones bear strong antioxidant potential and promising agents for hepatotoxicity prevention and stressed their potential role as therapeutic supplements in DILI. The current review will elaborate on isoflavones’ preventive and therapeutic potential concisely and highlight various molecular targets to exert a protective effect on DILI.http://dx.doi.org/10.1155/2021/2870969 |
| spellingShingle | Liangliang Yao Muhammad Farrukh Nisar Tingdong Yan Chunpeng (Craig) Wan Potential Effects of Dietary Isoflavones on Drug-Induced Liver Injury Journal of Food Quality |
| title | Potential Effects of Dietary Isoflavones on Drug-Induced Liver Injury |
| title_full | Potential Effects of Dietary Isoflavones on Drug-Induced Liver Injury |
| title_fullStr | Potential Effects of Dietary Isoflavones on Drug-Induced Liver Injury |
| title_full_unstemmed | Potential Effects of Dietary Isoflavones on Drug-Induced Liver Injury |
| title_short | Potential Effects of Dietary Isoflavones on Drug-Induced Liver Injury |
| title_sort | potential effects of dietary isoflavones on drug induced liver injury |
| url | http://dx.doi.org/10.1155/2021/2870969 |
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