Investigating the Relationship of Inflammatory Cytokines and Brain-Derived Neurotrophic Factor with Cognitive Functions in Multiple Sclerosis Patients
The aim of this study was to investigate the relationship between immunological factors and cognitive functions in patients with multiple sclerosis (MS). The methodology was fundamental in nature, and the research design was correlational. Patients diagnosed with multiple sclerosis comprised the res...
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University of Tehran
2024-12-01
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| Series: | پژوهشهای کاربردی روانشناختی |
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| Online Access: | https://japr.ut.ac.ir/article_99090_db885d0d523a7eb49864f4a8752ad656.pdf |
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| author | Narges َArab-Moghaddam Karim Asgari Mobarakeh Gholamreza Daryabor Maryam Poursadeghfard |
| author_facet | Narges َArab-Moghaddam Karim Asgari Mobarakeh Gholamreza Daryabor Maryam Poursadeghfard |
| author_sort | Narges َArab-Moghaddam |
| collection | DOAJ |
| description | The aim of this study was to investigate the relationship between immunological factors and cognitive functions in patients with multiple sclerosis (MS). The methodology was fundamental in nature, and the research design was correlational. Patients diagnosed with multiple sclerosis comprised the research population. 68 patients with multiple sclerosis (MS) were selected through convenience sampling. These patients were divided into three groups: 23 newly diagnosed patients (ND), 23 patients with relapsing-remitting MS (RRMS), and 22 patients with secondary progressive types (SPMS). The patients were 55 women and 13 men. Additionally, the control group consisted of 22 healthy individuals (17 women and 5 men) who were matched based on their age, gender, and educational background. The ELISA method was used to measure the serum levels of cytokines IFN-γ, IL-6, TNF-α, and IL-17, as well as brain-derived neurogenesis factor (BDNF) in the control group and the patients. California Verbal Learning Tests (CVLT-11), Brief Spatial Memory-Revised (BVMT-R), Symbol Digit Substitution (SDMT), Verbal Fluency (COWAT), and Executive Functions (D-KEFS) were implemented to assess cognitive functions. SPSS-26 software was employed to analyze the data that was obtained using the regression method. Compared to the control group, patients exhibited substantial variations in cognitive functions and serum levels of cytokines IFN-γ, IL-17, and BDNF. In RRMS and ND patients, BDNF was a positive predictor of visual-spatial memory and executive function. In ND patients, IFN-γ was a negative predictor of executive function, and TNF-α was a negative predictor of information processing speed in SPMS patients. Neurotrophic factor BDNF and cytokines IFN-γ and IL-17 are potential biomarkers for the assessment of certain cognitive functions in patients with multiple sclerosis. |
| format | Article |
| id | doaj-art-58f6c41f99f44c58940f87958915eaa2 |
| institution | Kabale University |
| issn | 2251-8126 2676-4504 |
| language | fas |
| publishDate | 2024-12-01 |
| publisher | University of Tehran |
| record_format | Article |
| series | پژوهشهای کاربردی روانشناختی |
| spelling | doaj-art-58f6c41f99f44c58940f87958915eaa22025-01-10T04:25:50ZfasUniversity of Tehranپژوهشهای کاربردی روانشناختی2251-81262676-45042024-12-01154698910.22059/japr.2024.9909099090Investigating the Relationship of Inflammatory Cytokines and Brain-Derived Neurotrophic Factor with Cognitive Functions in Multiple Sclerosis PatientsNarges َArab-Moghaddam0Karim Asgari Mobarakeh1Gholamreza Daryabor2Maryam Poursadeghfard3Department of Psychology, Faculty of Education and Psychology, Isfahan University, Isfahan, Iran.Department of Psychology, Faculty of Education and Psychology, University of Isfahan Isfahan, Iran.Department of Immunology, Autoimmune Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran,Department of Neurology, Clinical Neurology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.The aim of this study was to investigate the relationship between immunological factors and cognitive functions in patients with multiple sclerosis (MS). The methodology was fundamental in nature, and the research design was correlational. Patients diagnosed with multiple sclerosis comprised the research population. 68 patients with multiple sclerosis (MS) were selected through convenience sampling. These patients were divided into three groups: 23 newly diagnosed patients (ND), 23 patients with relapsing-remitting MS (RRMS), and 22 patients with secondary progressive types (SPMS). The patients were 55 women and 13 men. Additionally, the control group consisted of 22 healthy individuals (17 women and 5 men) who were matched based on their age, gender, and educational background. The ELISA method was used to measure the serum levels of cytokines IFN-γ, IL-6, TNF-α, and IL-17, as well as brain-derived neurogenesis factor (BDNF) in the control group and the patients. California Verbal Learning Tests (CVLT-11), Brief Spatial Memory-Revised (BVMT-R), Symbol Digit Substitution (SDMT), Verbal Fluency (COWAT), and Executive Functions (D-KEFS) were implemented to assess cognitive functions. SPSS-26 software was employed to analyze the data that was obtained using the regression method. Compared to the control group, patients exhibited substantial variations in cognitive functions and serum levels of cytokines IFN-γ, IL-17, and BDNF. In RRMS and ND patients, BDNF was a positive predictor of visual-spatial memory and executive function. In ND patients, IFN-γ was a negative predictor of executive function, and TNF-α was a negative predictor of information processing speed in SPMS patients. Neurotrophic factor BDNF and cytokines IFN-γ and IL-17 are potential biomarkers for the assessment of certain cognitive functions in patients with multiple sclerosis.https://japr.ut.ac.ir/article_99090_db885d0d523a7eb49864f4a8752ad656.pdfautoimmunitybrain-derived neurogenesis factorcognitive functionsinflammatory cytokinesmultiple sclerosis |
| spellingShingle | Narges َArab-Moghaddam Karim Asgari Mobarakeh Gholamreza Daryabor Maryam Poursadeghfard Investigating the Relationship of Inflammatory Cytokines and Brain-Derived Neurotrophic Factor with Cognitive Functions in Multiple Sclerosis Patients پژوهشهای کاربردی روانشناختی autoimmunity brain-derived neurogenesis factor cognitive functions inflammatory cytokines multiple sclerosis |
| title | Investigating the Relationship of Inflammatory Cytokines and Brain-Derived Neurotrophic Factor with Cognitive Functions in Multiple Sclerosis Patients |
| title_full | Investigating the Relationship of Inflammatory Cytokines and Brain-Derived Neurotrophic Factor with Cognitive Functions in Multiple Sclerosis Patients |
| title_fullStr | Investigating the Relationship of Inflammatory Cytokines and Brain-Derived Neurotrophic Factor with Cognitive Functions in Multiple Sclerosis Patients |
| title_full_unstemmed | Investigating the Relationship of Inflammatory Cytokines and Brain-Derived Neurotrophic Factor with Cognitive Functions in Multiple Sclerosis Patients |
| title_short | Investigating the Relationship of Inflammatory Cytokines and Brain-Derived Neurotrophic Factor with Cognitive Functions in Multiple Sclerosis Patients |
| title_sort | investigating the relationship of inflammatory cytokines and brain derived neurotrophic factor with cognitive functions in multiple sclerosis patients |
| topic | autoimmunity brain-derived neurogenesis factor cognitive functions inflammatory cytokines multiple sclerosis |
| url | https://japr.ut.ac.ir/article_99090_db885d0d523a7eb49864f4a8752ad656.pdf |
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