Relationship Between 8-iso-prostaglandin-F<sub>2α</sub> and Predicted 10-Year Cardiovascular Risk in Hypertensive Patients
Background: 8-iso-prostaglandin-F<sub>2α</sub> (8-iso-PGF<sub>2α</sub>) is a recognized marker of oxidative stress. Previous studies suggested that 8-iso-PGF<sub>2α</sub> plays an important role in the pathogenesis of hypertension and cardiovascular (CV) diseases....
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2025-03-01
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| author | Giulio Geraci Alessandra Sorce Luca Zanoli Giuseppe Cuttone Vincenzo Calabrese Francesco Pallotti Valentina Paternò Pietro Ferrara Ligia J. Dominguez Riccardo Polosa Jacob George Giuseppe Mulè Caterina Carollo |
| author_facet | Giulio Geraci Alessandra Sorce Luca Zanoli Giuseppe Cuttone Vincenzo Calabrese Francesco Pallotti Valentina Paternò Pietro Ferrara Ligia J. Dominguez Riccardo Polosa Jacob George Giuseppe Mulè Caterina Carollo |
| author_sort | Giulio Geraci |
| collection | DOAJ |
| description | Background: 8-iso-prostaglandin-F<sub>2α</sub> (8-iso-PGF<sub>2α</sub>) is a recognized marker of oxidative stress. Previous studies suggested that 8-iso-PGF<sub>2α</sub> plays an important role in the pathogenesis of hypertension and cardiovascular (CV) diseases. However, limited data exist on the prognostic role of 8-iso-PGF<sub>2α</sub> in hypertensive patients undergoing primary prevention. The aim of this study was to assess the relationship between 8-iso-PGF<sub>2α</sub> and 10-year CV risk, as predicted by validated equations in hypertension patients without CV diseases. Materials and methods: A total of 432 individuals aged 40–75 years were enrolled. Plasma 8-iso-PGF<sub>2α</sub> was assessed through the ELISA method. CV risk was calculated by using the Framingham Risk Score (Fr-S) and the Atherosclerosis Cardiovascular Disease Risk Score (ASCVD-S). Low, moderate, or high CV risks were defined according to validated cutoffs. Results: Individuals with higher CV risk had significantly greater 8-iso-PGF<sub>2α</sub> values compared to those with low or moderate CV risk (<i>p</i> < 0.001). 8-iso-PGF<sub>2α</sub> correlated strongly with Fr-S and ASCVD-S in the entire population and in patients with normal renal function (all <i>p</i> < 0.001) but not in patients with eGFR < 60 mL/min/1.73 m<sup>2</sup>. These associations remained significant after adjustment for traditional factors included in the CV risk equations in the overall population and in patients with normal renal function. The 8-iso-PGF<sub>2α</sub> cutoffs that best distinguished patients with high CV risk were 310 pg/mL for Fr-S and 264 pg/mL for ASCVD-S in the overall population, with significant differences between the groups divided by eGFR (all <i>p</i> < 0.001). Conclusions: These findings highlight the potential utility of 8-iso-PGF<sub>2α</sub> as a biomarker for refining cardiovascular risk stratification in hypertensive patients, particularly those with preserved renal function. Future studies should explore its prognostic value in longitudinal cohorts and assess its integration into clinical risk models to enhance early prevention strategies for cardiovascular disease. |
| format | Article |
| id | doaj-art-58f37fefe06d4132a0e14eb7ffd9daa7 |
| institution | Kabale University |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-03-01 |
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| spelling | doaj-art-58f37fefe06d4132a0e14eb7ffd9daa72025-08-20T03:43:36ZengMDPI AGLife2075-17292025-03-0115340110.3390/life15030401Relationship Between 8-iso-prostaglandin-F<sub>2α</sub> and Predicted 10-Year Cardiovascular Risk in Hypertensive PatientsGiulio Geraci0Alessandra Sorce1Luca Zanoli2Giuseppe Cuttone3Vincenzo Calabrese4Francesco Pallotti5Valentina Paternò6Pietro Ferrara7Ligia J. Dominguez8Riccardo Polosa9Jacob George10Giuseppe Mulè11Caterina Carollo12Department of Medicine and Surgery, Kore University of Enna, 94100 Enna, ItalyUnit of Nephrology and Dialysis, Hypertension Excellence Centre, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90133 Palermo, ItalyNephrology, Department of Clinical and Experimental Medicine, University of Catania, 95124 Catania, ItalyDepartment of Medicine and Surgery, Kore University of Enna, 94100 Enna, ItalyDepartment of Medicine and Surgery, Kore University of Enna, 94100 Enna, ItalyDepartment of Medicine and Surgery, Kore University of Enna, 94100 Enna, ItalyOperative Unit of Diabetology, Umberto I Hospital, Provincial Health Authority (ASP) of Enna, 94100 Enna, ItalyCenter for Public Health Research, University of Milan–Bicocca, 20900 Monza, ItalyDepartment of Medicine and Surgery, Kore University of Enna, 94100 Enna, ItalyDepartment of Medicine and Surgery, Kore University of Enna, 94100 Enna, ItalyCardiovascular Medicine and Therapeutics, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, UKUnit of Nephrology and Dialysis, Hypertension Excellence Centre, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90133 Palermo, ItalyUnit of Nephrology and Dialysis, Hypertension Excellence Centre, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90133 Palermo, ItalyBackground: 8-iso-prostaglandin-F<sub>2α</sub> (8-iso-PGF<sub>2α</sub>) is a recognized marker of oxidative stress. Previous studies suggested that 8-iso-PGF<sub>2α</sub> plays an important role in the pathogenesis of hypertension and cardiovascular (CV) diseases. However, limited data exist on the prognostic role of 8-iso-PGF<sub>2α</sub> in hypertensive patients undergoing primary prevention. The aim of this study was to assess the relationship between 8-iso-PGF<sub>2α</sub> and 10-year CV risk, as predicted by validated equations in hypertension patients without CV diseases. Materials and methods: A total of 432 individuals aged 40–75 years were enrolled. Plasma 8-iso-PGF<sub>2α</sub> was assessed through the ELISA method. CV risk was calculated by using the Framingham Risk Score (Fr-S) and the Atherosclerosis Cardiovascular Disease Risk Score (ASCVD-S). Low, moderate, or high CV risks were defined according to validated cutoffs. Results: Individuals with higher CV risk had significantly greater 8-iso-PGF<sub>2α</sub> values compared to those with low or moderate CV risk (<i>p</i> < 0.001). 8-iso-PGF<sub>2α</sub> correlated strongly with Fr-S and ASCVD-S in the entire population and in patients with normal renal function (all <i>p</i> < 0.001) but not in patients with eGFR < 60 mL/min/1.73 m<sup>2</sup>. These associations remained significant after adjustment for traditional factors included in the CV risk equations in the overall population and in patients with normal renal function. The 8-iso-PGF<sub>2α</sub> cutoffs that best distinguished patients with high CV risk were 310 pg/mL for Fr-S and 264 pg/mL for ASCVD-S in the overall population, with significant differences between the groups divided by eGFR (all <i>p</i> < 0.001). Conclusions: These findings highlight the potential utility of 8-iso-PGF<sub>2α</sub> as a biomarker for refining cardiovascular risk stratification in hypertensive patients, particularly those with preserved renal function. Future studies should explore its prognostic value in longitudinal cohorts and assess its integration into clinical risk models to enhance early prevention strategies for cardiovascular disease.https://www.mdpi.com/2075-1729/15/3/401oxidative stress8-iso-prostaglandin-F<sub>2α</sub> cardiovascular riskhypertensionchronic kidney diseaseinflammationprevention |
| spellingShingle | Giulio Geraci Alessandra Sorce Luca Zanoli Giuseppe Cuttone Vincenzo Calabrese Francesco Pallotti Valentina Paternò Pietro Ferrara Ligia J. Dominguez Riccardo Polosa Jacob George Giuseppe Mulè Caterina Carollo Relationship Between 8-iso-prostaglandin-F<sub>2α</sub> and Predicted 10-Year Cardiovascular Risk in Hypertensive Patients Life oxidative stress 8-iso-prostaglandin-F<sub>2α</sub> cardiovascular risk hypertension chronic kidney disease inflammation prevention |
| title | Relationship Between 8-iso-prostaglandin-F<sub>2α</sub> and Predicted 10-Year Cardiovascular Risk in Hypertensive Patients |
| title_full | Relationship Between 8-iso-prostaglandin-F<sub>2α</sub> and Predicted 10-Year Cardiovascular Risk in Hypertensive Patients |
| title_fullStr | Relationship Between 8-iso-prostaglandin-F<sub>2α</sub> and Predicted 10-Year Cardiovascular Risk in Hypertensive Patients |
| title_full_unstemmed | Relationship Between 8-iso-prostaglandin-F<sub>2α</sub> and Predicted 10-Year Cardiovascular Risk in Hypertensive Patients |
| title_short | Relationship Between 8-iso-prostaglandin-F<sub>2α</sub> and Predicted 10-Year Cardiovascular Risk in Hypertensive Patients |
| title_sort | relationship between 8 iso prostaglandin f sub 2α sub and predicted 10 year cardiovascular risk in hypertensive patients |
| topic | oxidative stress 8-iso-prostaglandin-F<sub>2α</sub> cardiovascular risk hypertension chronic kidney disease inflammation prevention |
| url | https://www.mdpi.com/2075-1729/15/3/401 |
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