Evaluation of structural changes in orbitofrontal cortex in relation to medication overuse in migraine patients: a diffusion tensor imaging study
Abstract Background: Migraine is a prevalent neurological disease that leads to severe headaches. Moreover, it is the commonest among the primary headaches that cause medication overuse headache (MOH). The orbitofrontal cortex (OFC) is one of the structures most associated with medication overuse....
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Thieme Revinter Publicações
2021-07-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000600483&tlng=en |
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| author | Aygul Tantik Pak Sebahat Nacar Dogan Yildizhan Sengul |
| author_facet | Aygul Tantik Pak Sebahat Nacar Dogan Yildizhan Sengul |
| author_sort | Aygul Tantik Pak |
| collection | DOAJ |
| description | Abstract Background: Migraine is a prevalent neurological disease that leads to severe headaches. Moreover, it is the commonest among the primary headaches that cause medication overuse headache (MOH). The orbitofrontal cortex (OFC) is one of the structures most associated with medication overuse. Objective: To determine microstructural changes in the OFC among migraine patients who developed MOH, through the diffusion tensor imaging (DTI) technique. Methods: Fifty-eight patients who had been diagnosed with migraine based on the Classification of Headache Disorders (ICHD-III-B) were included in the study. Patients were sub-classified into two groups, with and without MOH, based on the MOH criteria of ICHD-III-B. DTI was applied to each patient. The OFC fractional anisotropy (FA), and apparent diffusion coefficient (ADC) values of the two groups were compared. Results: The mean age of all the patients was 35.98±7.92 years (range: 18-65), and 84.5% (n=49) of them were female. The two groups, with MOH (n=25) and without (n=33), were alike in terms of age, gender, family history, migraine with or without aura and duration of illness. It was found that there was a significant difference in FA values of the left OFC between the two groups (0.32±0.01 versus 0.29±0.01; p=0.04). Conclusions: An association was found between MOH and changes to OFC microstructure. Determination of neuropathology and factors associated with medication overuse among migraine patients is crucial in terms of identifying the at-risk patient population and improving proper treatment strategies specific to these patients. |
| format | Article |
| id | doaj-art-58eee6c54b7649cf95480d746750e4cd |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-58eee6c54b7649cf95480d746750e4cd2025-08-20T03:19:34ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272021-07-0179648348810.1590/0004-282x-anp-2020-0360Evaluation of structural changes in orbitofrontal cortex in relation to medication overuse in migraine patients: a diffusion tensor imaging studyAygul Tantik Pakhttps://orcid.org/0000-0002-7414-3800Sebahat Nacar Doganhttps://orcid.org/0000-0003-1512-5060Yildizhan Sengulhttps://orcid.org/0000-0002-5087-9944Abstract Background: Migraine is a prevalent neurological disease that leads to severe headaches. Moreover, it is the commonest among the primary headaches that cause medication overuse headache (MOH). The orbitofrontal cortex (OFC) is one of the structures most associated with medication overuse. Objective: To determine microstructural changes in the OFC among migraine patients who developed MOH, through the diffusion tensor imaging (DTI) technique. Methods: Fifty-eight patients who had been diagnosed with migraine based on the Classification of Headache Disorders (ICHD-III-B) were included in the study. Patients were sub-classified into two groups, with and without MOH, based on the MOH criteria of ICHD-III-B. DTI was applied to each patient. The OFC fractional anisotropy (FA), and apparent diffusion coefficient (ADC) values of the two groups were compared. Results: The mean age of all the patients was 35.98±7.92 years (range: 18-65), and 84.5% (n=49) of them were female. The two groups, with MOH (n=25) and without (n=33), were alike in terms of age, gender, family history, migraine with or without aura and duration of illness. It was found that there was a significant difference in FA values of the left OFC between the two groups (0.32±0.01 versus 0.29±0.01; p=0.04). Conclusions: An association was found between MOH and changes to OFC microstructure. Determination of neuropathology and factors associated with medication overuse among migraine patients is crucial in terms of identifying the at-risk patient population and improving proper treatment strategies specific to these patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000600483&tlng=enMigraine DisordersMedication Overuse HeadacheOrbitofrontal CortexDiffusion Tensor Imaging |
| spellingShingle | Aygul Tantik Pak Sebahat Nacar Dogan Yildizhan Sengul Evaluation of structural changes in orbitofrontal cortex in relation to medication overuse in migraine patients: a diffusion tensor imaging study Arquivos de Neuro-Psiquiatria Migraine Disorders Medication Overuse Headache Orbitofrontal Cortex Diffusion Tensor Imaging |
| title | Evaluation of structural changes in orbitofrontal cortex in relation to medication overuse in migraine patients: a diffusion tensor imaging study |
| title_full | Evaluation of structural changes in orbitofrontal cortex in relation to medication overuse in migraine patients: a diffusion tensor imaging study |
| title_fullStr | Evaluation of structural changes in orbitofrontal cortex in relation to medication overuse in migraine patients: a diffusion tensor imaging study |
| title_full_unstemmed | Evaluation of structural changes in orbitofrontal cortex in relation to medication overuse in migraine patients: a diffusion tensor imaging study |
| title_short | Evaluation of structural changes in orbitofrontal cortex in relation to medication overuse in migraine patients: a diffusion tensor imaging study |
| title_sort | evaluation of structural changes in orbitofrontal cortex in relation to medication overuse in migraine patients a diffusion tensor imaging study |
| topic | Migraine Disorders Medication Overuse Headache Orbitofrontal Cortex Diffusion Tensor Imaging |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000600483&tlng=en |
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