Is there an association between superoxide dismutase gene polymorphisms, antioxidants in oxidative stress pathway, and oral health-related quality of life after root canal treatment?
Objective: To evaluate the association between genetic polymorphisms in SOD2 and SOD3 and oral health-related quality of life (OHRQoL). Material and methods: The cohort study included 109 participants, all of whom underwent root canal treatment on a single-rooted maxillary or mandibular tooth wi...
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Medical Journals Sweden
2025-04-01
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| Series: | Acta Odontologica Scandinavica |
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| Online Access: | https://medicaljournalssweden.se/actaodontologica/article/view/43426 |
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| author | Ludmila da Silva Guimarães Erlange Andrade Borges da Silva Juliana Miranda Bonelli Heitor Ganier Ribeiro Alice Corrêa Silva-Sousa Manoel Damião Sousa-Neto Erika Calvano Küchler Lívia Azeredo Alves Antunes Fernanda Signorelli Calazans Leonardo Santos Antunes |
| author_facet | Ludmila da Silva Guimarães Erlange Andrade Borges da Silva Juliana Miranda Bonelli Heitor Ganier Ribeiro Alice Corrêa Silva-Sousa Manoel Damião Sousa-Neto Erika Calvano Küchler Lívia Azeredo Alves Antunes Fernanda Signorelli Calazans Leonardo Santos Antunes |
| author_sort | Ludmila da Silva Guimarães |
| collection | DOAJ |
| description |
Objective: To evaluate the association between genetic polymorphisms in SOD2 and SOD3 and oral health-related quality of life (OHRQoL).
Material and methods: The cohort study included 109 participants, all of whom underwent root canal treatment on a single-rooted maxillary or mandibular tooth with asymptomatic periapical periodontitis. The OHRQoL was assessed using the Oral Health Impact Profile-14 at three intervals: prior to root canal treatment (T0), 7 (T7), and 30 (T30) days post-treatment. Genomic DNA was extracted from buccal cells for genotyping of polymorphisms in SOD2 (rs5746136, rs4880, and rs10370) and SOD3 (rs2855262 and rs13306703) using real-time PCR. Both Univariate and Multivariate Poisson Regression analyses were conducted, with p < 0.05 indicating statistical significance.
Results: The rs2855262 polymorphism in the SOD3 gene showed a significant difference in the functional limitation domain in both codominant (p = 0.037) and recessive (p = 0.040) models. The rs13306703 polymorphism in SOD3 demonstrated a significant difference in physical pain [in codominant (p = 0.001) and recessive (p < 0.001) models], psychological discomfort [in codominant (p = 0.002) and recessive (p = 0.002) models], handicap [in codominant (p = 0.011) and dominant (p = 0.015) models], and total score [in codominant (p = 0.011) and recessive (p = 0.007) models]. In the Multivariate Poisson Regression analysis, SOD2 (rs5746136) was associated with the psychological disability domain [in codominant (p = 0.049) and recessive (p = 0.040) models] and SOD3 (rs13306703), in the handicap domain [in codominant (p = 0.028) and dominant (p = 0.037) models].
Conclusions: Genetic polymorphisms in SOD2 and SOD3 genes can influence the OHRQoL response in patients with asymptomatic periapical periodontitis.
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| format | Article |
| id | doaj-art-58eea794b42a4f3e82f1b2dce592a9bd |
| institution | OA Journals |
| issn | 0001-6357 1502-3850 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Medical Journals Sweden |
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| series | Acta Odontologica Scandinavica |
| spelling | doaj-art-58eea794b42a4f3e82f1b2dce592a9bd2025-08-20T02:24:35ZengMedical Journals SwedenActa Odontologica Scandinavica0001-63571502-38502025-04-018410.2340/aos.v84.43426Is there an association between superoxide dismutase gene polymorphisms, antioxidants in oxidative stress pathway, and oral health-related quality of life after root canal treatment?Ludmila da Silva Guimarães0Erlange Andrade Borges da Silva1Juliana Miranda Bonelli2Heitor Ganier Ribeiro3Alice Corrêa Silva-Sousa4Manoel Damião Sousa-Neto5Erika Calvano Küchler6Lívia Azeredo Alves Antunes7Fernanda Signorelli Calazans8Leonardo Santos Antunes9Postgraduate Program, School of Dentistry, Fluminense Federal University, Niterói, Rio de Janeiro, BrazilPostgraduate Program, School of Dentistry, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, BrazilSpecific Formation Department, School of Dentistry of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, BrazilSpecific Formation Department, School of Dentistry of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, BrazilRestorative Dentistry Department, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, BrazilRestorative Dentistry Department, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, BrazilDepartment of Orthodontics, University Hospital Bonn, Bonn, GermanPostgraduate Program, School of Dentistry, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil; Postgraduate Program, School of Dentistry, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil; Specific Formation Department, School of Dentistry of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, BrazilPostgraduate Program, School of Dentistry, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil; Specific Formation Department, School of Dentistry of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, BrazilPostgraduate Program, School of Dentistry, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil; Postgraduate Program, School of Dentistry, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil; Specific Formation Department, School of Dentistry of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil Objective: To evaluate the association between genetic polymorphisms in SOD2 and SOD3 and oral health-related quality of life (OHRQoL). Material and methods: The cohort study included 109 participants, all of whom underwent root canal treatment on a single-rooted maxillary or mandibular tooth with asymptomatic periapical periodontitis. The OHRQoL was assessed using the Oral Health Impact Profile-14 at three intervals: prior to root canal treatment (T0), 7 (T7), and 30 (T30) days post-treatment. Genomic DNA was extracted from buccal cells for genotyping of polymorphisms in SOD2 (rs5746136, rs4880, and rs10370) and SOD3 (rs2855262 and rs13306703) using real-time PCR. Both Univariate and Multivariate Poisson Regression analyses were conducted, with p < 0.05 indicating statistical significance. Results: The rs2855262 polymorphism in the SOD3 gene showed a significant difference in the functional limitation domain in both codominant (p = 0.037) and recessive (p = 0.040) models. The rs13306703 polymorphism in SOD3 demonstrated a significant difference in physical pain [in codominant (p = 0.001) and recessive (p < 0.001) models], psychological discomfort [in codominant (p = 0.002) and recessive (p = 0.002) models], handicap [in codominant (p = 0.011) and dominant (p = 0.015) models], and total score [in codominant (p = 0.011) and recessive (p = 0.007) models]. In the Multivariate Poisson Regression analysis, SOD2 (rs5746136) was associated with the psychological disability domain [in codominant (p = 0.049) and recessive (p = 0.040) models] and SOD3 (rs13306703), in the handicap domain [in codominant (p = 0.028) and dominant (p = 0.037) models]. Conclusions: Genetic polymorphisms in SOD2 and SOD3 genes can influence the OHRQoL response in patients with asymptomatic periapical periodontitis. https://medicaljournalssweden.se/actaodontologica/article/view/43426Genetic polymorphismoxidative stresssuperoxide dismutaseoral health-related quality of lifeperiapical periodontitis |
| spellingShingle | Ludmila da Silva Guimarães Erlange Andrade Borges da Silva Juliana Miranda Bonelli Heitor Ganier Ribeiro Alice Corrêa Silva-Sousa Manoel Damião Sousa-Neto Erika Calvano Küchler Lívia Azeredo Alves Antunes Fernanda Signorelli Calazans Leonardo Santos Antunes Is there an association between superoxide dismutase gene polymorphisms, antioxidants in oxidative stress pathway, and oral health-related quality of life after root canal treatment? Acta Odontologica Scandinavica Genetic polymorphism oxidative stress superoxide dismutase oral health-related quality of life periapical periodontitis |
| title | Is there an association between superoxide dismutase gene polymorphisms, antioxidants in oxidative stress pathway, and oral health-related quality of life after root canal treatment? |
| title_full | Is there an association between superoxide dismutase gene polymorphisms, antioxidants in oxidative stress pathway, and oral health-related quality of life after root canal treatment? |
| title_fullStr | Is there an association between superoxide dismutase gene polymorphisms, antioxidants in oxidative stress pathway, and oral health-related quality of life after root canal treatment? |
| title_full_unstemmed | Is there an association between superoxide dismutase gene polymorphisms, antioxidants in oxidative stress pathway, and oral health-related quality of life after root canal treatment? |
| title_short | Is there an association between superoxide dismutase gene polymorphisms, antioxidants in oxidative stress pathway, and oral health-related quality of life after root canal treatment? |
| title_sort | is there an association between superoxide dismutase gene polymorphisms antioxidants in oxidative stress pathway and oral health related quality of life after root canal treatment |
| topic | Genetic polymorphism oxidative stress superoxide dismutase oral health-related quality of life periapical periodontitis |
| url | https://medicaljournalssweden.se/actaodontologica/article/view/43426 |
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