Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet
Background. Recently, we found large reductions in visceral and subcutaneous fat one month after gastric bypass (GBP), without any change in liver fat content. Purpose. Firstly to characterize weight loss-induced lipid mobilization after one month with preoperative low-calorie diet (LCD) and a subse...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2011/959601 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850225372137783296 |
|---|---|
| author | Joel Kullberg Magnus Sundbom Arvo Haenni Susanne Freden Lars Johansson Peter Börnert Anders Ahlström Håkan Ahlström Anders Karlsson |
| author_facet | Joel Kullberg Magnus Sundbom Arvo Haenni Susanne Freden Lars Johansson Peter Börnert Anders Ahlström Håkan Ahlström Anders Karlsson |
| author_sort | Joel Kullberg |
| collection | DOAJ |
| description | Background. Recently, we found large reductions in visceral and subcutaneous fat one month after gastric bypass (GBP), without any change in liver fat content. Purpose. Firstly to characterize weight loss-induced lipid mobilization after one month with preoperative low-calorie diet (LCD) and a subsequent month following GBP, and secondly, to discuss the observations with reference to our previous published findings after GBP intervention alone. Methods. 15 morbidly obese women were studied prior to LCD, at GBP, and one month after GBP. Effects on metabolism were measured by magnetic resonance techniques and blood tests. Results. Body weight was similarly reduced after both months (mean: −8.0 kg, n=13). Relative body fat changes were smaller after LCD than after GBP (−7.1±3.6% versus −10±3.2%, P=.029, n=13). Liver fat fell during the LCD month (−41%, P=.001, n=13) but was unaltered one month after GBP (+12%). Conclusion. Gastric bypass seems to cause a greater lipid mobilization than a comparable LCD-induced weight loss. One may speculate that GBP-altered gastrointestinal signalling sensitizes adipose tissue to lipolysis, promoting the changes observed. |
| format | Article |
| id | doaj-art-58ed2237f7764df1bbdfe267648e346a |
| institution | OA Journals |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-58ed2237f7764df1bbdfe267648e346a2025-08-20T02:05:23ZengWileyJournal of Obesity2090-07082090-07162011-01-01201110.1155/2011/959601959601Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie DietJoel Kullberg0Magnus Sundbom1Arvo Haenni2Susanne Freden3Lars Johansson4Peter Börnert5Anders Ahlström6Håkan Ahlström7Anders Karlsson8Department of Radiology, Uppsala University, 751 85 Uppsala, SwedenDepartment of Surgery, Uppsala University, 751 85 Uppsala, SwedenDepartment of Public Health and Caring Sciences, Uppsala University, 751 85 Uppsala, SwedenDepartment of Public Health and Caring Sciences, Uppsala University, 751 85 Uppsala, SwedenDepartment of Radiology, Uppsala University, 751 85 Uppsala, SwedenPhilips Research Europe, D-22335 Hamburg, GermanyDepartment of Surgery, Uppsala University, 751 85 Uppsala, SwedenDepartment of Radiology, Uppsala University, 751 85 Uppsala, SwedenDepartment of Medical Sciences, Uppsala University, 751 85 Uppsala, SwedenBackground. Recently, we found large reductions in visceral and subcutaneous fat one month after gastric bypass (GBP), without any change in liver fat content. Purpose. Firstly to characterize weight loss-induced lipid mobilization after one month with preoperative low-calorie diet (LCD) and a subsequent month following GBP, and secondly, to discuss the observations with reference to our previous published findings after GBP intervention alone. Methods. 15 morbidly obese women were studied prior to LCD, at GBP, and one month after GBP. Effects on metabolism were measured by magnetic resonance techniques and blood tests. Results. Body weight was similarly reduced after both months (mean: −8.0 kg, n=13). Relative body fat changes were smaller after LCD than after GBP (−7.1±3.6% versus −10±3.2%, P=.029, n=13). Liver fat fell during the LCD month (−41%, P=.001, n=13) but was unaltered one month after GBP (+12%). Conclusion. Gastric bypass seems to cause a greater lipid mobilization than a comparable LCD-induced weight loss. One may speculate that GBP-altered gastrointestinal signalling sensitizes adipose tissue to lipolysis, promoting the changes observed.http://dx.doi.org/10.1155/2011/959601 |
| spellingShingle | Joel Kullberg Magnus Sundbom Arvo Haenni Susanne Freden Lars Johansson Peter Börnert Anders Ahlström Håkan Ahlström Anders Karlsson Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet Journal of Obesity |
| title | Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet |
| title_full | Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet |
| title_fullStr | Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet |
| title_full_unstemmed | Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet |
| title_short | Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet |
| title_sort | gastric bypass promotes more lipid mobilization than a similar weight loss induced by low calorie diet |
| url | http://dx.doi.org/10.1155/2011/959601 |
| work_keys_str_mv | AT joelkullberg gastricbypasspromotesmorelipidmobilizationthanasimilarweightlossinducedbylowcaloriediet AT magnussundbom gastricbypasspromotesmorelipidmobilizationthanasimilarweightlossinducedbylowcaloriediet AT arvohaenni gastricbypasspromotesmorelipidmobilizationthanasimilarweightlossinducedbylowcaloriediet AT susannefreden gastricbypasspromotesmorelipidmobilizationthanasimilarweightlossinducedbylowcaloriediet AT larsjohansson gastricbypasspromotesmorelipidmobilizationthanasimilarweightlossinducedbylowcaloriediet AT peterbornert gastricbypasspromotesmorelipidmobilizationthanasimilarweightlossinducedbylowcaloriediet AT andersahlstrom gastricbypasspromotesmorelipidmobilizationthanasimilarweightlossinducedbylowcaloriediet AT hakanahlstrom gastricbypasspromotesmorelipidmobilizationthanasimilarweightlossinducedbylowcaloriediet AT anderskarlsson gastricbypasspromotesmorelipidmobilizationthanasimilarweightlossinducedbylowcaloriediet |