Simple UV Spectrophotometric Determination of Duloxetine Hydrochloride in Bulk and in Pharmaceutical Formulations
A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of duloxetine hydrochloride in bulk and in pharmaceutical formulations. Duloxetine hydrochloride exhibits absorption maxima at 288 nm with apparent molar absorptivity of 0.97x104 L/mo...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/709176 |
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| author | Mohammad Yunoos D. Gowri Sankar B. Pragati Kumar Shahul Hameed Azmath Hussain |
| author_facet | Mohammad Yunoos D. Gowri Sankar B. Pragati Kumar Shahul Hameed Azmath Hussain |
| author_sort | Mohammad Yunoos |
| collection | DOAJ |
| description | A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of duloxetine hydrochloride in bulk and in pharmaceutical formulations. Duloxetine hydrochloride exhibits absorption maxima at 288 nm with apparent molar absorptivity of 0.97x104 L/mol.cm in 0.1 N HCL. Beer's law was found to be obeyed in the concentration range of 5-30 μg/mL. The method is accurate, precise and economical. The proposed method has been applied successfully for the analysis of the drug in pure and in its capsule dosage forms. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically and by recovery studies. |
| format | Article |
| id | doaj-art-58db68cb6eb140ef90c9b2eacae196dd |
| institution | OA Journals |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-58db68cb6eb140ef90c9b2eacae196dd2025-08-20T02:05:23ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-017378578810.1155/2010/709176Simple UV Spectrophotometric Determination of Duloxetine Hydrochloride in Bulk and in Pharmaceutical FormulationsMohammad Yunoos0D. Gowri Sankar1B. Pragati Kumar2Shahul Hameed3Azmath Hussain4Nimra College of Pharmacy, Jupudi, Ibrahimpatnam, Vijayawada, IndiaUniversity College of Pharmaceutical Sciences, Andhra University, Visakhapatanam, Andhra Pradesh, IndiaNimra College of Pharmacy, Jupudi, Ibrahimpatnam, Vijayawada, IndiaNimra College of Pharmacy, Jupudi, Ibrahimpatnam, Vijayawada, IndiaNimra College of Pharmacy, Jupudi, Ibrahimpatnam, Vijayawada, IndiaA new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of duloxetine hydrochloride in bulk and in pharmaceutical formulations. Duloxetine hydrochloride exhibits absorption maxima at 288 nm with apparent molar absorptivity of 0.97x104 L/mol.cm in 0.1 N HCL. Beer's law was found to be obeyed in the concentration range of 5-30 μg/mL. The method is accurate, precise and economical. The proposed method has been applied successfully for the analysis of the drug in pure and in its capsule dosage forms. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically and by recovery studies.http://dx.doi.org/10.1155/2010/709176 |
| spellingShingle | Mohammad Yunoos D. Gowri Sankar B. Pragati Kumar Shahul Hameed Azmath Hussain Simple UV Spectrophotometric Determination of Duloxetine Hydrochloride in Bulk and in Pharmaceutical Formulations E-Journal of Chemistry |
| title | Simple UV Spectrophotometric Determination of Duloxetine Hydrochloride in Bulk and in Pharmaceutical Formulations |
| title_full | Simple UV Spectrophotometric Determination of Duloxetine Hydrochloride in Bulk and in Pharmaceutical Formulations |
| title_fullStr | Simple UV Spectrophotometric Determination of Duloxetine Hydrochloride in Bulk and in Pharmaceutical Formulations |
| title_full_unstemmed | Simple UV Spectrophotometric Determination of Duloxetine Hydrochloride in Bulk and in Pharmaceutical Formulations |
| title_short | Simple UV Spectrophotometric Determination of Duloxetine Hydrochloride in Bulk and in Pharmaceutical Formulations |
| title_sort | simple uv spectrophotometric determination of duloxetine hydrochloride in bulk and in pharmaceutical formulations |
| url | http://dx.doi.org/10.1155/2010/709176 |
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