Multiple drug resistance caused by germline mutation of exon 27 of BRCA2 gene in triple-negative breast cancer: a case report and literature review

Multiple drug resistance caused by germline mutation of exon 27 of BRCA2 gene in triple-negative breast cancer: a case report and literature review

BRCA genes, including BRCA1 and BRCA2, are tumor suppressor genes that play a crucial role in the HRR pathway for double-strand DNA breaks. Mutations in these genes lead to the loss of function of their respective proteins, resulting in HRD and the development of hereditary breast cancer. The BRCA2...

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Bibliographic Details
Main Authors: Yuting Li, Guojie Xu, Liling Zhang, Kewei Zhao, Yanxia Zhao, Dan Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
triple-negative breast cancer
BRCA2
frameshift mutation
treatment resistance
cancer progression
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1602870/full
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