ATRX loss in adult gliomas lacking H3 alterations or IDH mutations, an exceptional situation for exceptional diagnoses: the experience of Sainte-Anne hospital

ATRX loss in adult gliomas lacking H3 alterations or IDH mutations, an exceptional situation for exceptional diagnoses: the experience of Sainte-Anne hospital

Abstract ATRX immunostaining constitutes a routinely used biomarker for the practice of neuropathology. The loss of ATRX expression correlating with ATRX gene alterations is implicated in a wide variety of pediatric and adult gliomas, and has been indexed as a desirable or essential diagnostic crite...

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Bibliographic Details
Main Authors: Arnault Tauziède-Espariat, Alexandre Roux, Joseph Benzakoun, Paul Kauv, Sanaa Tazi, Alice Métais, Abigail K. Suwala, ·Felix Hinz, ·Lauren Hasty, Mathilde Filser, Julien Masliah-Planchon, Raphaël Saffroy, Margot Bucau, Johan Pallud, Pascale Varlet
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Acta Neuropathologica Communications
Subjects:
ATRX
Diffuse glioma
FH
HGAP
Online Access:https://doi.org/10.1186/s40478-025-02044-6
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