First presentation of acute intermittent porphyria with steroid-responsive encephalopathy associated with autoimmune thyroiditis
Steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT), also called Hashimoto’s encephalopathy (HE), a treatable disease, has a wide spectrum of clinical presentation and is therefore, often misdiagnosed. Acute intermittent porphyria (AIP) is a rare disease and its prevalen...
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| Format: | Article |
| Language: | English |
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Sri Lanka College of Internal Medicine
2025-03-01
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| Series: | Asian Journal of Internal Medicine |
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| Online Access: | https://account.ajim.sljol.info/index.php/sljo-j-ajim/article/view/290 |
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| author | M. W. K. De Zoysa W. Uluwattage E. Jasinge E. W. B. Edirisinghe |
| author_facet | M. W. K. De Zoysa W. Uluwattage E. Jasinge E. W. B. Edirisinghe |
| author_sort | M. W. K. De Zoysa |
| collection | DOAJ |
| description | Steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT), also called Hashimoto’s encephalopathy (HE), a treatable disease, has a wide spectrum of clinical presentation and is therefore, often misdiagnosed. Acute intermittent porphyria (AIP) is a rare disease and its prevalence in Sri Lanka is unknown. Coexistence or precipitation of AIP with thyroid illness is reported mainly related to hyperthyroidism. Here we report a case of a young girl who presented with abdominal pain, seizures, hypertension, hyponatraemia and subtle features of hypothyroidism who was successfully treated for SREAT with first AIP flare. This case highlights the possibility of coexistence of two rare entities in a single patient. |
| format | Article |
| id | doaj-art-58b8ac6ae2bf4a4681cbf3f45b8bcc45 |
| institution | DOAJ |
| issn | 2827-7260 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Sri Lanka College of Internal Medicine |
| record_format | Article |
| series | Asian Journal of Internal Medicine |
| spelling | doaj-art-58b8ac6ae2bf4a4681cbf3f45b8bcc452025-08-20T02:52:38ZengSri Lanka College of Internal MedicineAsian Journal of Internal Medicine2827-72602025-03-014110.4038/ajim.v4i1.290First presentation of acute intermittent porphyria with steroid-responsive encephalopathy associated with autoimmune thyroiditisM. W. K. De Zoysa0W. Uluwattage1E. Jasinge2E. W. B. Edirisinghe3Postgraduate Institute of Medicine, ColomboNational Hospital, GalleLady Ridgeway Hospital for Children, ColomboPostgraduate Institute of Medicine, ColomboSteroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT), also called Hashimoto’s encephalopathy (HE), a treatable disease, has a wide spectrum of clinical presentation and is therefore, often misdiagnosed. Acute intermittent porphyria (AIP) is a rare disease and its prevalence in Sri Lanka is unknown. Coexistence or precipitation of AIP with thyroid illness is reported mainly related to hyperthyroidism. Here we report a case of a young girl who presented with abdominal pain, seizures, hypertension, hyponatraemia and subtle features of hypothyroidism who was successfully treated for SREAT with first AIP flare. This case highlights the possibility of coexistence of two rare entities in a single patient.https://account.ajim.sljol.info/index.php/sljo-j-ajim/article/view/290Acute intermittent porphyriaSteroid responsive encephalopathy associated with autoimmune thyroiditisHypothyroidism |
| spellingShingle | M. W. K. De Zoysa W. Uluwattage E. Jasinge E. W. B. Edirisinghe First presentation of acute intermittent porphyria with steroid-responsive encephalopathy associated with autoimmune thyroiditis Asian Journal of Internal Medicine Acute intermittent porphyria Steroid responsive encephalopathy associated with autoimmune thyroiditis Hypothyroidism |
| title | First presentation of acute intermittent porphyria with steroid-responsive encephalopathy associated with autoimmune thyroiditis |
| title_full | First presentation of acute intermittent porphyria with steroid-responsive encephalopathy associated with autoimmune thyroiditis |
| title_fullStr | First presentation of acute intermittent porphyria with steroid-responsive encephalopathy associated with autoimmune thyroiditis |
| title_full_unstemmed | First presentation of acute intermittent porphyria with steroid-responsive encephalopathy associated with autoimmune thyroiditis |
| title_short | First presentation of acute intermittent porphyria with steroid-responsive encephalopathy associated with autoimmune thyroiditis |
| title_sort | first presentation of acute intermittent porphyria with steroid responsive encephalopathy associated with autoimmune thyroiditis |
| topic | Acute intermittent porphyria Steroid responsive encephalopathy associated with autoimmune thyroiditis Hypothyroidism |
| url | https://account.ajim.sljol.info/index.php/sljo-j-ajim/article/view/290 |
| work_keys_str_mv | AT mwkdezoysa firstpresentationofacuteintermittentporphyriawithsteroidresponsiveencephalopathyassociatedwithautoimmunethyroiditis AT wuluwattage firstpresentationofacuteintermittentporphyriawithsteroidresponsiveencephalopathyassociatedwithautoimmunethyroiditis AT ejasinge firstpresentationofacuteintermittentporphyriawithsteroidresponsiveencephalopathyassociatedwithautoimmunethyroiditis AT ewbedirisinghe firstpresentationofacuteintermittentporphyriawithsteroidresponsiveencephalopathyassociatedwithautoimmunethyroiditis |