Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen
Objective. The serum pepsinogen test has limitation in its predictive power as a noninvasive biomarker for gastric cancer screening. We aimed to investigate whether the combination of TFF3 and pepsinogen could be an effective biomarker for the detection of gastric cancer even in the early stages. Me...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/1024074 |
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| author | Hyun Seok Lee Seong Woo Jeon Sachiyo Nomura Yasuyuki Seto Yong Hwan Kwon Su Youn Nam Yuko Ishibashi Hiroshi Ohtsu Yasukazu Ohmoto Hae Min Yang |
| author_facet | Hyun Seok Lee Seong Woo Jeon Sachiyo Nomura Yasuyuki Seto Yong Hwan Kwon Su Youn Nam Yuko Ishibashi Hiroshi Ohtsu Yasukazu Ohmoto Hae Min Yang |
| author_sort | Hyun Seok Lee |
| collection | DOAJ |
| description | Objective. The serum pepsinogen test has limitation in its predictive power as a noninvasive biomarker for gastric cancer screening. We aimed to investigate whether the combination of TFF3 and pepsinogen could be an effective biomarker for the detection of gastric cancer even in the early stages. Methods. In total, 281 patients with early gastric cancer (EGC), who underwent endoscopic submucosal dissection in Korea, and 708 healthy individuals from Japan were enrolled in the derivation cohort. The validation cohort included 30 Korean patients with EGC and 30 Korean healthy control blood donors. Serum TFF3 levels were examined using enzyme-linked immunosorbent assay. Results. Using a cutoff of 6.73 ng/mL in the derivation cohort, the sensitivity of the combination of tests for EGC detection was superior (87.5%) to that of TFF3 (80.4%) or pepsinogen test alone (39.5%). Similarly, in the validation cohort, the sensitivity of TFF3 plus pepsinogen was higher (90.4%) than that of TFF3 (80.0%) or pepsinogen test alone (33.3%). Conclusion. The combination of serum TFF3 and pepsinogen is a more effective noninvasive biomarker for gastric cancer detection compared with pepsinogen or TFF3 alone, even in EGC. This trial is registered with NCT03046745. |
| format | Article |
| id | doaj-art-58b5f5f0f4cd4c3b9df4221eb9b09650 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-58b5f5f0f4cd4c3b9df4221eb9b096502025-08-20T02:05:20ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/10240741024074Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and PepsinogenHyun Seok Lee0Seong Woo Jeon1Sachiyo Nomura2Yasuyuki Seto3Yong Hwan Kwon4Su Youn Nam5Yuko Ishibashi6Hiroshi Ohtsu7Yasukazu Ohmoto8Hae Min Yang9Department of Internal Medicine, School of Medicine, Kyungpook National University Hospital, Kyungpook National University, Daegu, Republic of KoreaDepartment of Internal Medicine, School of Medicine, Kyungpook National University Hospital, Kyungpook National University, Daegu, Republic of KoreaDepartment of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, JapanDepartment of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, JapanDepartment of Internal Medicine, School of Medicine, Kyungpook National University Hospital, Kyungpook National University, Daegu, Republic of KoreaDepartment of Internal Medicine, School of Medicine, Kyungpook National University Hospital, Kyungpook National University, Daegu, Republic of KoreaDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, JapanDepartment of Clinical Trial Data Management, Graduate School of Medicine, University of Tokyo, Tokyo, JapanOtsuka Pharmaceutical Co. Ltd., Tokyo, JapanDepartment of Internal Medicine, School of Medicine, Kyungpook National University Hospital, Kyungpook National University, Daegu, Republic of KoreaObjective. The serum pepsinogen test has limitation in its predictive power as a noninvasive biomarker for gastric cancer screening. We aimed to investigate whether the combination of TFF3 and pepsinogen could be an effective biomarker for the detection of gastric cancer even in the early stages. Methods. In total, 281 patients with early gastric cancer (EGC), who underwent endoscopic submucosal dissection in Korea, and 708 healthy individuals from Japan were enrolled in the derivation cohort. The validation cohort included 30 Korean patients with EGC and 30 Korean healthy control blood donors. Serum TFF3 levels were examined using enzyme-linked immunosorbent assay. Results. Using a cutoff of 6.73 ng/mL in the derivation cohort, the sensitivity of the combination of tests for EGC detection was superior (87.5%) to that of TFF3 (80.4%) or pepsinogen test alone (39.5%). Similarly, in the validation cohort, the sensitivity of TFF3 plus pepsinogen was higher (90.4%) than that of TFF3 (80.0%) or pepsinogen test alone (33.3%). Conclusion. The combination of serum TFF3 and pepsinogen is a more effective noninvasive biomarker for gastric cancer detection compared with pepsinogen or TFF3 alone, even in EGC. This trial is registered with NCT03046745.http://dx.doi.org/10.1155/2018/1024074 |
| spellingShingle | Hyun Seok Lee Seong Woo Jeon Sachiyo Nomura Yasuyuki Seto Yong Hwan Kwon Su Youn Nam Yuko Ishibashi Hiroshi Ohtsu Yasukazu Ohmoto Hae Min Yang Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen Gastroenterology Research and Practice |
| title | Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen |
| title_full | Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen |
| title_fullStr | Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen |
| title_full_unstemmed | Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen |
| title_short | Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen |
| title_sort | screening biomarker as an alternative to endoscopy for the detection of early gastric cancer the combination of serum trefoil factor family 3 and pepsinogen |
| url | http://dx.doi.org/10.1155/2018/1024074 |
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