Ghrelin alleviates high glucose-induced retinal microvascular endothelial cell injury by activating Nrf2/HO-1 pathway to inhibit ferroptosis

Ghrelin alleviates high glucose-induced retinal microvascular endothelial cell injury by activating Nrf2/HO-1 pathway to inhibit ferroptosis

AIM: To investigate the protective role of ghrelin against diabetic retinopathy (DR), focusing on its anti-ferroptotic mechanism in high glucose-induced retinal endothelial injury. METHODS: First, small interfering RNA (siRNA)-mediated interference was conducted to knockdown nuclear factor erythroid...

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Bibliographic Details
Main Authors: Fen-Fen Wang, Rong Li, Dan Liao, Chao-Qun Liu, Xiao-Li Yang
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2025-06-01
Series:International Journal of Ophthalmology
Subjects:
ghrelin
human retinal microvascular endothelial cells
ferroptosis
nuclear factor erythroid 2-related factor 2
haem oxygenase-1
oxidative stress
Online Access:http://ies.ijo.cn/en_publish/2025/6/20250602.pdf
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