Fiber isolated from discarded fruits and vegetables reduces valproic acid-induced hepatotoxicity in rats
Abstract In this work, a methodology was developed to obtain dietary fiber from agro-industrial fruit and vegetable waste. The resulting raw material was named DF. The physicochemical analysis revealed a high total dietary fiber content, along with an appropriate soluble to insoluble fiber ratio and...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universidade de São Paulo
2025-01-01
|
| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100305&lng=en&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832592496215982080 |
|---|---|
| author | Maria Rosana Ramirez Debora Manuale Juan Carlos Yori |
| author_facet | Maria Rosana Ramirez Debora Manuale Juan Carlos Yori |
| author_sort | Maria Rosana Ramirez |
| collection | DOAJ |
| description | Abstract In this work, a methodology was developed to obtain dietary fiber from agro-industrial fruit and vegetable waste. The resulting raw material was named DF. The physicochemical analysis revealed a high total dietary fiber content, along with an appropriate soluble to insoluble fiber ratio and excellent water and fat retention capacity. Subsequently, its potential protective effect against hepatotoxicity induced by valproic acid (VPA) was investigated in Wistar rats, both as preventive and curative treatments. For this purpose, two different trials were conducted. In the preventive trial, VPA (250 mg/kg/day; oral) was administered concomitantly with DF (0.3 and 0.15 mg/kg/day) for 14 days. In the curative trial, VPA was administered for 14 days, followed by DF for an additional 14 days. The results demonstrated that DF supplementation normalized body weight, liver biomarkers and attenuated VPA-induced tissue damage, while normal liver architecture was preserved. These findings suggest that DF obtained from agro-industrial fruit and vegetable waste materials may serve as a functional feedstock to counteract the harmful effects associated with prolonged VPA treatment. |
| format | Article |
| id | doaj-art-58afb9ea6ddd45119c2815fbc637c36b |
| institution | Kabale University |
| issn | 2175-9790 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj-art-58afb9ea6ddd45119c2815fbc637c36b2025-01-21T07:42:05ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902025-01-016110.1590/s2175-97902025e23830Fiber isolated from discarded fruits and vegetables reduces valproic acid-induced hepatotoxicity in ratsMaria Rosana Ramirezhttps://orcid.org/0000-0001-9989-7978Debora ManualeJuan Carlos YoriAbstract In this work, a methodology was developed to obtain dietary fiber from agro-industrial fruit and vegetable waste. The resulting raw material was named DF. The physicochemical analysis revealed a high total dietary fiber content, along with an appropriate soluble to insoluble fiber ratio and excellent water and fat retention capacity. Subsequently, its potential protective effect against hepatotoxicity induced by valproic acid (VPA) was investigated in Wistar rats, both as preventive and curative treatments. For this purpose, two different trials were conducted. In the preventive trial, VPA (250 mg/kg/day; oral) was administered concomitantly with DF (0.3 and 0.15 mg/kg/day) for 14 days. In the curative trial, VPA was administered for 14 days, followed by DF for an additional 14 days. The results demonstrated that DF supplementation normalized body weight, liver biomarkers and attenuated VPA-induced tissue damage, while normal liver architecture was preserved. These findings suggest that DF obtained from agro-industrial fruit and vegetable waste materials may serve as a functional feedstock to counteract the harmful effects associated with prolonged VPA treatment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100305&lng=en&tlng=enCircular economyFiberWasteHepatotoxicitySodium valproate |
| spellingShingle | Maria Rosana Ramirez Debora Manuale Juan Carlos Yori Fiber isolated from discarded fruits and vegetables reduces valproic acid-induced hepatotoxicity in rats Brazilian Journal of Pharmaceutical Sciences Circular economy Fiber Waste Hepatotoxicity Sodium valproate |
| title | Fiber isolated from discarded fruits and vegetables reduces valproic acid-induced hepatotoxicity in rats |
| title_full | Fiber isolated from discarded fruits and vegetables reduces valproic acid-induced hepatotoxicity in rats |
| title_fullStr | Fiber isolated from discarded fruits and vegetables reduces valproic acid-induced hepatotoxicity in rats |
| title_full_unstemmed | Fiber isolated from discarded fruits and vegetables reduces valproic acid-induced hepatotoxicity in rats |
| title_short | Fiber isolated from discarded fruits and vegetables reduces valproic acid-induced hepatotoxicity in rats |
| title_sort | fiber isolated from discarded fruits and vegetables reduces valproic acid induced hepatotoxicity in rats |
| topic | Circular economy Fiber Waste Hepatotoxicity Sodium valproate |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100305&lng=en&tlng=en |
| work_keys_str_mv | AT mariarosanaramirez fiberisolatedfromdiscardedfruitsandvegetablesreducesvalproicacidinducedhepatotoxicityinrats AT deboramanuale fiberisolatedfromdiscardedfruitsandvegetablesreducesvalproicacidinducedhepatotoxicityinrats AT juancarlosyori fiberisolatedfromdiscardedfruitsandvegetablesreducesvalproicacidinducedhepatotoxicityinrats |