Involuntary intoxication caused by vaping the synthetic cannabinoid ADB-BUTINACA: A case report
Synthetic cannabinoids are gaining popularity globally and detection is not commonly available. We report a 27-year-old man who was admitted to the emergency room because of sudden headache, nausea, vertigo, red eyes and palpitations. He confirmed that he had been vaping an electronic cigarette (e-c...
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| Language: | English |
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Elsevier
2025-06-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750025000484 |
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| author | Elise M.A. Slob Maryam Lyousoufi Sharif Pasha Erik B. Wilms |
| author_facet | Elise M.A. Slob Maryam Lyousoufi Sharif Pasha Erik B. Wilms |
| author_sort | Elise M.A. Slob |
| collection | DOAJ |
| description | Synthetic cannabinoids are gaining popularity globally and detection is not commonly available. We report a 27-year-old man who was admitted to the emergency room because of sudden headache, nausea, vertigo, red eyes and palpitations. He confirmed that he had been vaping an electronic cigarette (e-cigarette) earlier that day just before the onset of his symptoms. Despite all negative results in the point-of-care test for recreational drugs, the liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) analysis showed that the liquid of the e-cigarette contained ADB-BUTINACA, a synthetic cannabinoid. LC-QTOF-MS represents a significant advancement in the field of drug detection, offering higher sensitivity, specificity, and a broader spectrum of detectable substances. Clinicians should be aware that besides the harmful effects of nicotine and toxic metals in e-cigarettes, e-cigarettes may also contain synthetic cannabinoids or other recreational drugs including new psychoactive substances (NPS), which can cause involuntary intoxication with potentially severe adverse effects. When clinical presentation and/or initial recreational drugs testing results are inconclusive, additional testing with LC-QTOF-MS can be valuable. |
| format | Article |
| id | doaj-art-58ae7d27024e43a382482d3d78c09a0e |
| institution | Kabale University |
| issn | 2214-7500 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj-art-58ae7d27024e43a382482d3d78c09a0e2025-02-02T05:27:35ZengElsevierToxicology Reports2214-75002025-06-0114101930Involuntary intoxication caused by vaping the synthetic cannabinoid ADB-BUTINACA: A case reportElise M.A. Slob0Maryam Lyousoufi1Sharif Pasha2Erik B. Wilms3Department of Clinical Pharmacy, Haaglanden Medical Center, The Hague, the Netherlands; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Clinical Pharmacy, Haaglanden Medical Center, The Hague, the Netherlands; Apotheek Haagse Ziekenhuizen (AHZ), Laboratory of TDM and Toxicology, The Hague, the Netherlands; Correspondence to: Apotheek Haagse Ziekenhuizen, Laboratory of TDM and Toxicology, Charlotte Jacobslaan 70, 2545 AB The Hague, the Netherlands.Department of Internal Medicine, Haaglanden Medical Center, The Hague, the NetherlandsApotheek Haagse Ziekenhuizen (AHZ), Laboratory of TDM and Toxicology, The Hague, the NetherlandsSynthetic cannabinoids are gaining popularity globally and detection is not commonly available. We report a 27-year-old man who was admitted to the emergency room because of sudden headache, nausea, vertigo, red eyes and palpitations. He confirmed that he had been vaping an electronic cigarette (e-cigarette) earlier that day just before the onset of his symptoms. Despite all negative results in the point-of-care test for recreational drugs, the liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) analysis showed that the liquid of the e-cigarette contained ADB-BUTINACA, a synthetic cannabinoid. LC-QTOF-MS represents a significant advancement in the field of drug detection, offering higher sensitivity, specificity, and a broader spectrum of detectable substances. Clinicians should be aware that besides the harmful effects of nicotine and toxic metals in e-cigarettes, e-cigarettes may also contain synthetic cannabinoids or other recreational drugs including new psychoactive substances (NPS), which can cause involuntary intoxication with potentially severe adverse effects. When clinical presentation and/or initial recreational drugs testing results are inconclusive, additional testing with LC-QTOF-MS can be valuable.http://www.sciencedirect.com/science/article/pii/S2214750025000484ADB-BUTINACAVapingSynthetic cannabinoidE-cigarette |
| spellingShingle | Elise M.A. Slob Maryam Lyousoufi Sharif Pasha Erik B. Wilms Involuntary intoxication caused by vaping the synthetic cannabinoid ADB-BUTINACA: A case report Toxicology Reports ADB-BUTINACA Vaping Synthetic cannabinoid E-cigarette |
| title | Involuntary intoxication caused by vaping the synthetic cannabinoid ADB-BUTINACA: A case report |
| title_full | Involuntary intoxication caused by vaping the synthetic cannabinoid ADB-BUTINACA: A case report |
| title_fullStr | Involuntary intoxication caused by vaping the synthetic cannabinoid ADB-BUTINACA: A case report |
| title_full_unstemmed | Involuntary intoxication caused by vaping the synthetic cannabinoid ADB-BUTINACA: A case report |
| title_short | Involuntary intoxication caused by vaping the synthetic cannabinoid ADB-BUTINACA: A case report |
| title_sort | involuntary intoxication caused by vaping the synthetic cannabinoid adb butinaca a case report |
| topic | ADB-BUTINACA Vaping Synthetic cannabinoid E-cigarette |
| url | http://www.sciencedirect.com/science/article/pii/S2214750025000484 |
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