Microneedles for Continuous, Minimally Invasive Monitoring: A Technology Overview
Abstract Microneedles are small piercing structures, with sizes in the micron‐to‐millimeter range, designed to penetrate painlessly the outer skin layer, known as stratum corneum, providing minimally invasive access to interstitial fluid (ISF), which enables the monitoring of biochemical parameters...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2025-07-01
|
| Series: | Advanced Sensor Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/adsr.202500057 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849321246427185152 |
|---|---|
| author | Guillermo Conejo‐Cuevas Miguel Aller Pellitero Leire Ruiz‐Rubio Francisco Javier del Campo |
| author_facet | Guillermo Conejo‐Cuevas Miguel Aller Pellitero Leire Ruiz‐Rubio Francisco Javier del Campo |
| author_sort | Guillermo Conejo‐Cuevas |
| collection | DOAJ |
| description | Abstract Microneedles are small piercing structures, with sizes in the micron‐to‐millimeter range, designed to penetrate painlessly the outer skin layer, known as stratum corneum, providing minimally invasive access to interstitial fluid (ISF), which enables the monitoring of biochemical parameters in real‐time. This review covers recent progress to date in the area of electrochemical sensing using microneedles, and provides an overview of fabrication materials and processes, as well as applications. The main body of the review focuses on the fabrication of microneedle structures and their transformation into electrochemical biosensors for continuous monitoring. To this end, the main recognition elements and electrode functionalization ways are described, paying closer attention to aptamers and continuous aptamer‐based sensing, whose importance, merits, and limitations are highlighted. In addition to covering the main current applications, the review discusses the future threats and opportunities of microneedle‐based in vivo monitoring. |
| format | Article |
| id | doaj-art-58a931c356f94d7aa25ead58e2789dbe |
| institution | Kabale University |
| issn | 2751-1219 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Sensor Research |
| spelling | doaj-art-58a931c356f94d7aa25ead58e2789dbe2025-08-20T03:49:49ZengWiley-VCHAdvanced Sensor Research2751-12192025-07-0147n/an/a10.1002/adsr.202500057Microneedles for Continuous, Minimally Invasive Monitoring: A Technology OverviewGuillermo Conejo‐Cuevas0Miguel Aller Pellitero1Leire Ruiz‐Rubio2Francisco Javier del Campo3BCMaterials Basque Center for Materials Applications and Nanostructures UPV/EHU Science Park Leioa Vizcaya 48940 SpainDepartamento de Química Física y Analítica Universidad de Oviedo Av. Julián Clavería 8 Oviedo 33006 SpainBCMaterials Basque Center for Materials Applications and Nanostructures UPV/EHU Science Park Leioa Vizcaya 48940 SpainBCMaterials Basque Center for Materials Applications and Nanostructures UPV/EHU Science Park Leioa Vizcaya 48940 SpainAbstract Microneedles are small piercing structures, with sizes in the micron‐to‐millimeter range, designed to penetrate painlessly the outer skin layer, known as stratum corneum, providing minimally invasive access to interstitial fluid (ISF), which enables the monitoring of biochemical parameters in real‐time. This review covers recent progress to date in the area of electrochemical sensing using microneedles, and provides an overview of fabrication materials and processes, as well as applications. The main body of the review focuses on the fabrication of microneedle structures and their transformation into electrochemical biosensors for continuous monitoring. To this end, the main recognition elements and electrode functionalization ways are described, paying closer attention to aptamers and continuous aptamer‐based sensing, whose importance, merits, and limitations are highlighted. In addition to covering the main current applications, the review discusses the future threats and opportunities of microneedle‐based in vivo monitoring.https://doi.org/10.1002/adsr.202500057aptamerselectrochemical sensorsinterstitial fluidmicroneedleswearable biosensors |
| spellingShingle | Guillermo Conejo‐Cuevas Miguel Aller Pellitero Leire Ruiz‐Rubio Francisco Javier del Campo Microneedles for Continuous, Minimally Invasive Monitoring: A Technology Overview Advanced Sensor Research aptamers electrochemical sensors interstitial fluid microneedles wearable biosensors |
| title | Microneedles for Continuous, Minimally Invasive Monitoring: A Technology Overview |
| title_full | Microneedles for Continuous, Minimally Invasive Monitoring: A Technology Overview |
| title_fullStr | Microneedles for Continuous, Minimally Invasive Monitoring: A Technology Overview |
| title_full_unstemmed | Microneedles for Continuous, Minimally Invasive Monitoring: A Technology Overview |
| title_short | Microneedles for Continuous, Minimally Invasive Monitoring: A Technology Overview |
| title_sort | microneedles for continuous minimally invasive monitoring a technology overview |
| topic | aptamers electrochemical sensors interstitial fluid microneedles wearable biosensors |
| url | https://doi.org/10.1002/adsr.202500057 |
| work_keys_str_mv | AT guillermoconejocuevas microneedlesforcontinuousminimallyinvasivemonitoringatechnologyoverview AT miguelallerpellitero microneedlesforcontinuousminimallyinvasivemonitoringatechnologyoverview AT leireruizrubio microneedlesforcontinuousminimallyinvasivemonitoringatechnologyoverview AT franciscojavierdelcampo microneedlesforcontinuousminimallyinvasivemonitoringatechnologyoverview |